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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pml
promyelocytic leukemia
MGI:104662
25 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pmltm1(PML/RARA)Ley/Pml+
involves: C57BL/6 		no abnormal phenotype detected J:172024
Pmltm1(PML/RARA)Ley/Pml+
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 		normal hematopoietic system phenotype J:172024
increased leukemia incidence J:172024
Pmltm1(PML/RARA)Ley/Pml+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		prenatal lethality, complete penetrance J:172024
Pmltm1(PML/RARA)Ley/Pml+
Tg(CMV-cre)1Cgn/0
involves: BALB/cJ * C57BL/6 		prenatal lethality, complete penetrance J:172024
Pmltm1(PML/RARA)Ley/Pml+
Tg(CAG-cre/Esr1*)5Amc/0
involves: BALB/cJ * C57BL/6 * CBA 		abnormal hematopoietic stem cell physiology J:172024
decreased hematopoietic stem cell number J:172024
enlarged spleen J:172024
Pmltm1.1Ews/Pmltm1.1Ews
Tg(PML-RARA)556Kog/0
FVB.Cg-Pmltm1.1Ews Tg(PML-RARA)556Kog 		abnormal double-strand DNA break repair J:262172
anemia J:262172
enlarged spleen J:262172
increased acute promyelocytic leukemia incidence J:262172
increased leukocyte cell number J:262172
thrombocytosis J:262172
Pmltm1Ppp/Pml+
Trp53tm3.1Glo/Trp53+
B6.129S7(Cg)-Pmltm1Ppp Trp53tm3.1Glo 		decreased body weight J:317504
decreased tumor-free survival time J:317504
extramedullary hematopoiesis J:317504
hepatosplenomegaly J:317504
increased B cell derived lymphoma incidence J:317504
increased carcinoma incidence J:317504
increased lymphoma incidence J:317504
increased osteosarcoma incidence J:317504
increased sarcoma incidence J:317504
increased T cell derived lymphoma incidence J:317504
premature death J:317504
Pmltm1Ppp/Pml+
Trp53tm3.1Glo/Trp53tm3.1Glo
B6.129S7(Cg)-Pmltm1Ppp Trp53tm3.1Glo 		premature death J:317504
prenatal lethality, incomplete penetrance J:317504
Pmltm1Ppp/Pmltm1Ppp
Trp53tm3.1Glo/Trp53+
B6.129S7(Cg)-Pmltm1Ppp Trp53tm3.1Glo 		decreased tumor-free survival time J:317504
normal growth/size/body region phenotype J:317504
normal hematopoietic system phenotype J:317504
hepatosplenomegaly J:317504
increased B cell derived lymphoma incidence J:317504
increased carcinoma incidence J:317504
increased lymphoma incidence J:317504
increased osteosarcoma incidence J:317504
increased sarcoma incidence J:317504
increased T cell derived lymphoma incidence J:317504
Pmltm1Ppp/Pmltm1Ppp
Trp53tm3.1Glo/Trp53tm3.1Glo
B6.129S7(Cg)-Pmltm1Ppp Trp53tm3.1Glo 		premature death J:317504
prenatal lethality, incomplete penetrance J:317504
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory