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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lep
leptin
MGI:104663
240 phenotypes from 11 alleles in 27 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Lepm1Btlr/Lepm1Btlr
C57BL/6J-Lepm1Btlr 		increased body fat mass J:189953
obese J:189953
Lepm1Yst/Lepm1Yst
C57BL/6J-Lepm1Yst 		abnormal eating behavior J:167736
abnormal gonadal fat pad morphology J:167736
decreased body temperature J:167736
hepatic steatosis J:167736
impaired glucose tolerance J:167736
increased body length J:167736
increased body weight J:167736
increased brown adipose tissue amount J:167736
increased brown fat cell lipid droplet size J:167736
increased circulating cholesterol level J:167736
increased circulating glucose level J:167736
increased circulating insulin level J:167736
increased circulating leptin level J:167736
increased circulating triglyceride level J:167736
increased defecation amount J:167736
increased heart weight J:167736
increased inguinal fat pad weight J:167736
increased kidney weight J:167736
increased liver weight J:167736
increased macrophage cell number J:167736
increased total body fat amount J:167736
increased white adipose tissue amount J:167736
increased white fat cell number J:167736
increased white fat cell size J:167736
infertility J:167736
insulin resistance J:167736
obese J:167736
pale liver J:167736
polyuria J:167736
Lepm2Btlr/Lepm2Btlr
C57BL/6J-Lepm2Btlr 		obese J:234238
Lepob/Lep+
involves: 129X1/SvJ * C57BL/6 		increased liver weight J:76479
Lepob/Lep+
involves: C57BL/6J 		increased bone mass J:60001
Lepob/Lepob-2J
involves: C57BL/6J * SM/Ckc 		obese J:30778
Lepob/Lepob
B6.Cg-Lepob/J 		abnormal body weight J:22025, J:29075
abnormal bone marrow morphology J:189019
abnormal circulating cholesterol level J:18161
abnormal circulating glucose level J:5400
abnormal epididymal fat pad morphology J:22377
abnormal food intake J:122746
abnormal frequency of paradoxical sleep J:115771
abnormal liver weight J:22377
abnormal muscle morphology J:151518
abnormal myocardial fiber morphology J:103063, J:104171, J:111488
abnormal myocardial fiber physiology J:104171
abnormal oxygen consumption J:22025, J:22377
abnormal pain threshold J:152019
abnormal pancreatic beta cell physiology J:5400
abnormal protein level J:22025
abnormal skeletal muscle fiber type ratio J:151518
abnormal sleep pattern J:115771
abnormal sympathetic nervous system physiology J:145998
abnormal urine catecholamine level J:4033
abnormal urine homeostasis J:4033
allodynia J:152019
decreased body temperature J:129662
decreased cardiac muscle contractility J:104171, J:111488
decreased circulating glucose level J:129554, J:145998, J:189019
decreased food intake J:29075
decreased insulin secretion J:145998
decreased locomotor activity J:115771, J:122746
decreased NK cell number J:117826
decreased oxygen consumption J:22377
decreased skeletal muscle fiber size J:151518
decreased skeletal muscle mass J:151518
decreased white fat cell number J:22377
enlarged pancreatic islets J:5400
female infertility J:122746
fragmentation of sleep/wake states J:115771
heart left ventricle hypertrophy J:103063
hyperalgesia J:152019
hyperglycemia J:5400, J:65486, J:122746
hypoglycemia J:5400
impaired glucose tolerance J:104171, J:107486
increased body weight J:185261
increased circulating cholesterol level J:18161
increased circulating HDL cholesterol level J:18161
increased circulating insulin level J:5400, J:104171, J:122746
increased circulating LDL cholesterol level J:18161
increased circulating triglyceride level J:18161, J:104171
increased circulating VLDL cholesterol level J:18161
increased fat cell size J:189019
increased food intake J:129662
increased growth rate J:5400
increased insulin secretion J:145998
increased interscapular fat pad weight J:22377
increased metastatic potential J:117826
increased myocardial fiber size J:104171
increased oxygen consumption J:22377
increased percent body fat/body weight J:122746
insulin resistance J:104171
lung inflammation J:115772
obese J:103063, J:104171
polyphagia J:122746
Lepob/Lepob
B6.Cg-Lepob/JBomTac 		increased circulating triglyceride level J:149091
Lepob/Lepob
B6.Cg-Lepob/JRj 		abnormal cell cycle J:220381
abnormal hepatocyte physiology J:220381
hepatic steatosis J:277927
normal homeostasis/metabolism phenotype J:277927
increased body weight J:277927
increased cholesterol level J:277927
increased circulating free fatty acids level J:277927
increased hepatocyte apoptosis J:277927
increased susceptibility to diet-induced obesity J:277927
liver fibrosis J:277927
liver inflammation J:277927
macrovesicular hepatic steatosis J:277927
oxidative stress J:220381
Lepob/Lepob
B6.Cg-Lepob/OlaHsd 		abnormal acute inflammation J:124815
abnormal chemokine secretion J:124815
abnormal digestive system physiology J:124815
abnormal intestinal epithelium morphology J:124815
increased interleukin-6 secretion J:124815
increased susceptibility to endotoxin shock J:124815
liver inflammation J:124815
Lepob/Lepob
BKS.Cg-Lepob/J 		abnormal circulating cholesterol level J:18161
abnormal circulating glucose level J:5400
abnormal pancreatic beta cell physiology J:5400
hyperglycemia J:5400
increased circulating cholesterol level J:18161
increased circulating HDL cholesterol level J:18161
increased circulating insulin level J:5400
increased circulating LDL cholesterol level J:18161
increased circulating triglyceride level J:18161
increased circulating VLDL cholesterol level J:18161
increased growth rate J:5400
increased urine glucose level J:5400
polyuria J:5400
premature death J:5400
small pancreatic islets J:5400
Lepob/Lepob
BTBR.Cg-Lepob 		hyperglycemia J:65486
Lepob/Lepob
BTBR.Cg-Lepob/WiscJ 		abnormal pancreatic islet morphology J:106121
abnormal podocyte morphology J:185261
albuminuria J:185261
normal cardiovascular system phenotype J:185261
decreased pancreatic beta cell mass J:106121
enlarged kidney J:185261
expanded mesangial matrix J:185261
glomerulosclerosis J:185261
hyperglycemia J:106121, J:185261
hypotension J:185261
impaired glucose tolerance J:106121
increased blood urea nitrogen level J:185261
increased body weight J:185261
increased cholesterol level J:185261
increased circulating insulin level J:106121
increased circulating triglyceride level J:106121, J:185261
increased kidney weight J:185261
increased renal glomerulus basement membrane thickness J:185261
insulin resistance J:106121
mesangiolysis J:185261
renal glomerulus hypertrophy J:185261
renal interstitial fibrosis J:185261
small pancreatic islets J:106121
Lepob/Lepob
D2.Cg-Lepob/Chua 		abnormal pancreatic islet morphology J:78850
decreased pancreatic beta cell number J:78850
hyperglycemia J:78850
increased circulating insulin level J:78850
increased pancreatic beta cell number J:78850
obese J:78850
Lepob/Lepob
FVB.Cg-Lepob/Chua 		hyperglycemia J:78850
increased circulating insulin level J:78850
Lepob/Lepob
involves: 129 * C57BL/6 		abnormal lipid level J:121534
abnormal pancreatic islet morphology J:121534
decreased locomotor activity J:121534
enlarged pancreatic islets J:121534
hepatic steatosis J:121534
increased body weight J:121534
increased circulating insulin level J:121534
increased insulin secretion J:121534
increased pancreatic islet number J:121534
increased percent body fat/body weight J:121534
insulin resistance J:121534
polyphagia J:121534
Lepob/Lepob
involves: 129X1/SvJ * C57BL/6 		abnormal adipose tissue amount J:107169
abnormal branching of the mammary ductal tree J:76479
abnormal circulating hormone level J:76479
abnormal circulating pancreatic peptide level J:76479
abnormal intestine morphology J:107169
abnormal vagina orifice morphology J:76479
absent corpus luteum J:76479
decreased circulating testosterone level J:76479, J:107169
decreased lean body mass J:107169
decreased primary ovarian follicle number J:76479
decreased secondary ovarian follicle number J:76479
decreased seminal vesicle weight J:76479
decreased testis weight J:76479, J:107169
female infertility J:76479
hyperglycemia J:107169
increased body weight J:107169
increased circulating cholesterol level J:107169
increased circulating corticosterone level J:76479, J:107169
increased circulating insulin level J:76479, J:107169
increased circulating leptin level J:76479
increased circulating triglyceride level J:107169
increased kidney weight J:107169
increased liver weight J:107169
increased pancreas weight J:107169
male infertility J:76479, J:107169
polyphagia J:107169
prolonged diestrus J:76479
prolonged estrous cycle J:76479
prolonged estrus J:76479
Lepob/Lepob
involves: BTBR * C57BL/6 * V stock 		decreased pancreatic beta cell number J:65486
disorganized pancreatic islets J:65486
hyperglycemia J:65486
increased circulating insulin level J:65486
pancreatic islet hyperplasia J:65486
Lepob/Lepob
involves: C57BL/6 		decreased CD4-positive, alpha-beta T cell number J:164339
decreased splenocyte number J:164339
decreased T cell proliferation J:164339
increased circulating cholesterol level J:72027
increased circulating HDL cholesterol level J:72027
increased circulating triglyceride level J:72027
increased liver cholesterol level J:72027
increased liver triglyceride level J:72027
Lepob/Lepob
involves: C57BL/6J 		abnormal behavior J:112820
abnormal cardiovascular system physiology J:116841
abnormal colon goblet cell morphology J:109110
abnormal corticosterone level J:13151
abnormal epidermal layer morphology J:121015
abnormal glucose homeostasis J:92558
abnormal hormone level J:13151
abnormal insulin secretion J:14402, J:22634
abnormal intestinal mucosa morphology J:109110
abnormal muscle contractility J:106205
abnormal osteoclast differentiation J:60001
abnormal postnatal growth J:6236
abnormal respiratory electron transport chain J:116841
abnormal retina vasculature morphology J:92072
abnormal skeleton development J:60001
decreased locomotor activity J:219118
decreased nerve conduction velocity J:121015
enlarged pancreatic islets J:219118
hepatic steatosis J:219118
hyperglycemia J:92558, J:219118
impaired glucose tolerance J:86303, J:219118
increased adrenocorticotropin level J:13151
increased body length J:219118
increased bone mass J:60001
increased circulating corticosterone level J:60001
increased circulating insulin level J:92558
increased fasting circulating glucose level J:219118
increased fat cell size J:5765, J:219118
increased gonadal fat pad weight J:219118
increased heart weight J:116841
increased inguinal fat pad weight J:219118
increased interscapular fat pad weight J:219118
increased lean body mass J:219118
increased liver weight J:219118
increased percent body fat/body weight J:219118
increased thermal nociceptive threshold J:121015
insulin resistance J:219118
obese J:92558, J:219118
osteopetrosis J:60001
polyphagia J:219118
postnatal lethality, incomplete penetrance J:219118
Lepob/Lepob
involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs 		abnormal arteriole morphology J:151096
abnormal cortical plate morphology J:105139
abnormal embryonic neuroepithelium morphology J:105139
abnormal fat cell morphology J:5253, J:7702
abnormal gland physiology J:7702
abnormal glucose homeostasis J:7702
abnormal hormone level J:7702
abnormal long bone epiphyseal plate morphology J:102535
abnormal long bone epiphyseal plate proliferative zone J:102535
abnormal long bone hypertrophic chondrocyte zone J:102535
abnormal microglial cell physiology J:115569
abnormal nucleotide metabolism J:260830
abnormal pancreatic beta cell morphology J:7702
abnormal response to cardiac infarction J:219470
abnormal vascular wound healing J:135034
abnormal white adipose tissue morphology J:260830
decreased activity of thyroid gland J:7702
decreased body length J:13066
decreased body temperature J:12010
decreased bone mass J:7702
decreased circulating tumor necrosis factor level J:115569
decreased embryonic neuroepithelial cell proliferation J:105139
decreased embryonic neuroepithelium thickness J:105139
decreased length of long bones J:102535
decreased liver triglyceride level J:199803
decreased susceptibility to hepatic steatosis J:199803
female infertility J:7702
hyperglycemia J:7702
hypersecretion of corticosterone J:7702
impaired adaptive thermogenesis J:7702, J:12010
impaired glucose tolerance J:7702
increased adrenocorticotropin level J:7702
increased body weight J:159285
increased circulating insulin level J:7702
increased fat cell size J:7702
increased growth rate J:13066
increased liver triglyceride level J:199803
increased pancreatic beta cell mass J:7702
increased pancreatic beta cell number J:7702
infertility J:7702
male infertility J:7702
polyphagia J:7702
reduced male fertility J:7702
short femur J:102535
short humerus J:102535
Lepob/Lepob
Tg(Npy-MAPT/Sapphire)1Rck/0
involves: C57BL/6 * CBA 		abnormal excitatory postsynaptic currents J:90242
abnormal neuron morphology J:90242
decreased body weight J:90242
decreased food intake J:90242
increased food intake J:90242
normal nervous system phenotype J:90242
Lepob/Lepob
Tg(Pomc-MAPT/Topaz)1Rck/0
involves: C57BL/6 * CBA 		abnormal inhibitory postsynaptic currents J:90242
abnormal neuron morphology J:90242
decreased body weight J:90242
decreased food intake J:90242
increased food intake J:90242
Leptm1.1Gvcao/Leptm1.1Gvcao
Tg(Adipoq-cre)1Evdr/0
involves: 129S4/SvJaeSor * C57BL/6J * FVB/NTac 		decreased circulating follicle stimulating hormone level J:218720
decreased circulating growth hormone level J:218720
decreased circulating leptin level J:218720
decreased circulating luteinizing hormone level J:218720
decreased circulating prolactin level J:218720
normal endocrine/exocrine gland phenotype J:218720
female infertility J:218720
increased pituitary hormone level J:218720
infertility J:218720
male infertility J:218720
obese J:218720
Leptm1.2Gvcao/Leptm1.2Gvcao
involves: 129S4/SvJaeSor * FVB/NJ * FVB/NTac 		decreased circulating follicle stimulating hormone level J:218720
decreased circulating leptin level J:218720
decreased circulating prolactin level J:218720
decreased pituitary hormone level J:218720
decreased somatotroph cell number J:218720
female infertility J:218720
increased body weight J:218720
infertility J:218720
male infertility J:218720
obese J:218720
Leptm1b(EUCOMM)Hmgu/Leptm1b(EUCOMM)Hmgu
C57BL/6N-Leptm1b(EUCOMM)Hmgu/Bay 		abnormal coat appearance J:211773
abnormal eye posterior chamber depth J:211773
abnormal retina inner nuclear layer morphology J:211773
decreased exploration in new environment J:211773
decreased grip strength J:211773
decreased heart rate J:211773
decreased heart weight J:211773
decreased locomotor activity J:211773
decreased spleen weight J:211773
decreased total retina thickness J:211773
decreased vertical activity J:211773
female infertility J:211773
increased anxiety-related response J:211773
increased cardiac stroke volume J:211773
increased cornea thickness J:211773
male infertility J:211773
prolonged QRS complex duration J:211773
short tibia J:211773
Leptm1Kry/Leptm1Kry
Not Specified 		increased bone mass J:88655
obese J:88655
Tg(Apcs-Lep)1Yog/0
involves: C57BL/6 * DBA/2 		abnormal food intake J:57075
abnormal glucose homeostasis J:57075
abnormal lipid level J:57075
decreased body weight J:57075
decreased brown adipose tissue amount J:57075
decreased circulating insulin level J:57075
decreased circulating triglyceride level J:57075
decreased liver glycogen level J:57075
decreased liver triglyceride level J:57075
decreased liver weight J:57075
decreased white adipose tissue amount J:57075
increased insulin sensitivity J:57075
small pancreatic islets J:57075
Tg(Apcs-Lep)1Yog/?
involves: C57BL/6 * DBA/2 		retina neovascularization J:92072
Tg(Apcs-Lep)1Yog/0
involves: C57BL/6J * FVB/N 		abnormal food intake J:69591
abnormal glucose homeostasis J:69591
abnormal lipid level J:69591
decreased body weight J:69591
decreased brown adipose tissue amount J:69591
decreased circulating free fatty acids level J:69591
decreased circulating glucose level J:69591
decreased circulating insulin level J:69591
decreased circulating triglyceride level J:69591
decreased white adipose tissue amount J:69591
increased insulin sensitivity J:69591
small liver J:69591
small pancreatic islets J:69591
Tg(Apcs-Lep)1Yog/0
Not Specified 		decreased bone mass J:88655
Tg(Apoe-Lep)1Kry/0
involves: FVB 		abnormal bone ossification J:88655
abnormal food intake J:88655
decreased bone mass J:88655
decreased total body fat amount J:88655
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory