About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tfap2a
transcription factor AP-2, alpha
MGI:104671
135 phenotypes from 8 alleles in 8 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Tfap2aMhdador/Tfap2a+
involves: C3HeB/FeJ 		abnormal incus morphology J:90701
abnormal malleus morphology J:90701
abnormal middle ear ossicle morphology J:90701
abnormal pinna reflex J:90701
abnormal stapes morphology J:90701
absent pinna reflex J:90701
conductive hearing loss J:90701
decreased cochlear nerve compound action potential J:90701
Tfap2aMhdador/Tfap2aMhdador
involves: C3HeB/FeJ 		abnormal iris morphology J:90701
abnormal lens morphology J:90701
narrow snout J:90701
perinatal lethality, complete penetrance J:90701
retina fold J:90701
short snout J:90701
small lens J:90701
Tfap2atm1.1Hsv/Tfap2atm1.1Hsv
involves: 129S1/Sv * Black Swiss * FVB/N 		abnormal aortic arch development J:73813
abnormal craniofacial development J:73813
abnormal heart ventricle outflow tract morphology J:73813
abnormal ventral body wall morphology J:73813
double outlet right ventricle J:73813
open neural tube J:73813
persistent right dorsal aorta J:73813
pulmonary valve atresia J:73813
pulmonary valve stenosis J:73813
retroesophageal right subclavian artery J:73813
ventricular septal defect J:73813
Tfap2atm1Hsv/Tfap2atm1Hsv
involves: 129S1/Sv * Black Swiss 		abnormal aortic arch development J:73813
abnormal craniofacial development J:73813
abnormal heart ventricle outflow tract morphology J:73813
abnormal ventral body wall morphology J:73813
double outlet right ventricle J:73813
open neural tube J:73813
persistent right dorsal aorta J:73813
pulmonary valve atresia J:73813
pulmonary valve stenosis J:73813
retroesophageal right subclavian artery J:73813
ventricular septal defect J:73813
Tfap2atm1Hsv/Tfap2atm2Will
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Not Specified 		abnormal facial skin morphology J:88826
abnormal foot pigmentation J:88826
abnormal frontonasal suture morphology J:88826
abnormal incus morphology J:88826
abnormal malleus morphology J:88826
abnormal nasal bone morphology J:88826
abnormal neurocranium morphology J:88826
abnormal palatal shelf fusion at midline J:88826
abnormal periorbital skin morphology J:88826
abnormal stapes morphology J:88826
abnormal tail pigmentation J:88826
abnormal zygomatic bone morphology J:88826
absent startle reflex J:88826
anencephaly J:88826
normal behavior/neurological phenotype J:88826
belly spot J:88826
broad nasal bone J:88826
normal cardiovascular system phenotype J:88826
normal cellular phenotype J:88826
decreased body weight J:88826
exencephaly J:88826
incomplete rostral neuropore closure J:88826
malocclusion J:88826
neonatal lethality, incomplete penetrance J:88826
normal nervous system phenotype J:88826
open neural tube J:88826
respiratory distress J:88826
short frontal bone J:88826
short maxilla J:88826
short nasal bone J:88826
short snout J:88826
small orbits J:88826
wide frontal bone J:88826
Tfap2atm1Jae/Tfap2a+
involves: 129P/Ola * 129S4/SvJae 		abnormal cranium morphology J:76797
abnormal middle ear ossicle morphology J:76797
abnormal neurocranium morphology J:76797
absent interparietal bone J:76797
absent nasal bone J:76797
absent parietal bone J:76797
exencephaly J:76797
open neural tube J:76797
pup cannibalization J:76797
short mandible J:76797
short maxilla J:76797
normal skeleton phenotype J:76797
small frontal bone J:76797
small zygomatic bone J:76797
Tfap2atm1Jae/Tfap2atm1Jae
either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) 		abnormal apoptosis J:33032
abnormal axial skeleton morphology J:33032
abnormal cranial ganglia morphology J:33032
abnormal cranium morphology J:33032
abnormal forebrain morphology J:33032
abnormal lens vesicle development J:33032
abnormal neural fold elevation formation J:33032
abnormal thoracic cage morphology J:33032
abnormal ventral body wall morphology J:33032
absent outer ear J:33032
absent radius J:33032
absent sternum J:33032
acrania J:33032
anophthalmia J:33032
cranioschisis J:33032
exencephaly J:33032
incomplete rostral neuropore closure J:33032
midline facial cleft J:33032
perinatal lethality, complete penetrance J:33032
scoliosis J:33032
small trigeminal ganglion J:33032
splayed ribs J:33032
Tfap2atm1Will/Tfap2a+
involves: Black Swiss 		normal hearing/vestibular/ear phenotype J:90701
Tfap2atm1Will/Tfap2atm1Will
involves: Black Swiss 		abnormal adrenal gland secretion J:81338
abnormal aortic arch morphology J:73813
abnormal cell death J:33031
abnormal cochlear ganglion morphology J:33031
abnormal cornea morphology J:52402
abnormal cranial nerve morphology J:33031
abnormal cranium morphology J:33031
abnormal dorsal-ventral axis patterning J:33031
abnormal facial nerve morphology J:33031
abnormal glossopharyngeal ganglion morphology J:33031
abnormal head morphology J:33031
abnormal lens induction J:52402
abnormal lens morphology J:52402
abnormal lens vesicle development J:52402
abnormal mandible morphology J:33031
abnormal neurocranium morphology J:33031
abnormal optic fissure closure J:52402
abnormal optic stalk morphology J:52402
abnormal retina pigment epithelium morphology J:52402
abnormal truncus arteriosus septation J:73813
abnormal vagus ganglion morphology J:33031
abnormal vestibular ganglion morphology J:33031
absent clavicle J:33031
absent eyelids J:52402
absent maxilla J:33031
absent middle ear ossicles J:33031
absent mouth J:33031
absent oculomotor nerve J:33031
absent outer ear J:33031
absent pericardium J:73813
absent radius J:33031
absent retina ganglion layer J:52402
absent snout J:33031
absent sternum J:33031
absent tympanic ring J:33031
anencephaly J:33031
aniridia J:52402
anophthalmia J:52402
decreased body size J:33031
double outlet right ventricle J:73813
normal embryo phenotype J:33031
normal endocrine/exocrine gland phenotype J:81338
exencephaly J:33031
interrupted aortic arch J:73813
interrupted aortic arch, type b J:73813
perinatal lethality, complete penetrance J:33031
persistent truncus arteriosus J:73813
retroesophageal right subclavian artery J:73813
scoliosis J:33031
normal skeleton phenotype J:33031
small lens J:52402
small trigeminal ganglion J:33031
thoracoabdominoschisis J:33031
Tfap2atm1Will/Tfap2atm2.1Will
involves: 129S1/Sv * Black Swiss 		abnormal craniofacial development J:217408
abnormal facial morphology J:217408
abnormal lateral nasal prominence morphology J:217408
abnormal maxilla morphology J:217408
abnormal maxillary prominence morphology J:217408
abnormal medial nasal prominence morphology J:217408
abnormal nasal pit morphology J:217408
abnormal neural tube closure J:217408
abnormal premaxilla morphology J:217408
abnormal secondary palate morphology J:217408
cleft palate J:217408
exencephaly J:217408
facial cleft J:217408
perinatal lethality J:217408
polydactyly J:217408
Tfap2atm2.1Will/Tfap2atm2.1Will
involves: 129S1/Sv * Black Swiss 		no abnormal phenotype detected J:217408
Tfap2atm2Will/Tfap2atm2Will
involves: 129 * Black Swiss 		no abnormal phenotype detected J:88826
Tfap2atm2Will/Tfap2atm2Will
HhatTg(TFAP2A-cre)1Will/0
Not Specified 		abnormal blood vessel morphology J:88829
abnormal frontonasal suture morphology J:88829
abnormal nasal bone morphology J:88829
abnormal nasal septum cartilage morphology J:88829
abnormal neurocranium morphology J:88829
normal limbs/digits/tail phenotype J:88829
malocclusion J:88829
ocular hypertelorism J:88829
short frontal bone J:88829
short nasal bone J:88829
short snout J:88829
Tfap2atm3Will/Tfap2atm3Will
involves: 129S1/Sv * Black Swiss 		polydactyly J:128903
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory