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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tfap2a
transcription factor AP-2, alpha
MGI:104671
135 phenotypes from 8 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tfap2aMhdador/Tfap2a+
involves: C3HeB/FeJ 		abnormal incus morphology J:90701
abnormal malleus morphology J:90701
abnormal middle ear ossicle morphology J:90701
abnormal pinna reflex J:90701
abnormal stapes morphology J:90701
absent pinna reflex J:90701
conductive hearing loss J:90701
decreased cochlear nerve compound action potential J:90701
Tfap2aMhdador/Tfap2aMhdador
involves: C3HeB/FeJ 		abnormal iris morphology J:90701
abnormal lens morphology J:90701
narrow snout J:90701
perinatal lethality, complete penetrance J:90701
retina fold J:90701
short snout J:90701
small lens J:90701
Tfap2atm1.1Hsv/Tfap2atm1.1Hsv
involves: 129S1/Sv * Black Swiss * FVB/N 		abnormal aortic arch development J:73813
abnormal craniofacial development J:73813
abnormal heart ventricle outflow tract morphology J:73813
abnormal ventral body wall morphology J:73813
double outlet right ventricle J:73813
open neural tube J:73813
persistent right dorsal aorta J:73813
pulmonary valve atresia J:73813
pulmonary valve stenosis J:73813
retroesophageal right subclavian artery J:73813
ventricular septal defect J:73813
Tfap2atm1Hsv/Tfap2atm1Hsv
involves: 129S1/Sv * Black Swiss 		abnormal aortic arch development J:73813
abnormal craniofacial development J:73813
abnormal heart ventricle outflow tract morphology J:73813
abnormal ventral body wall morphology J:73813
double outlet right ventricle J:73813
open neural tube J:73813
persistent right dorsal aorta J:73813
pulmonary valve atresia J:73813
pulmonary valve stenosis J:73813
retroesophageal right subclavian artery J:73813
ventricular septal defect J:73813
Tfap2atm1Hsv/Tfap2atm2Will
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Not Specified 		abnormal facial skin morphology J:88826
abnormal foot pigmentation J:88826
abnormal frontonasal suture morphology J:88826
abnormal incus morphology J:88826
abnormal malleus morphology J:88826
abnormal nasal bone morphology J:88826
abnormal neurocranium morphology J:88826
abnormal palatal shelf fusion at midline J:88826
abnormal periorbital skin morphology J:88826
abnormal stapes morphology J:88826
abnormal tail pigmentation J:88826
abnormal zygomatic bone morphology J:88826
absent startle reflex J:88826
anencephaly J:88826
normal behavior/neurological phenotype J:88826
belly spot J:88826
broad nasal bone J:88826
normal cardiovascular system phenotype J:88826
normal cellular phenotype J:88826
decreased body weight J:88826
exencephaly J:88826
incomplete rostral neuropore closure J:88826
malocclusion J:88826
neonatal lethality, incomplete penetrance J:88826
normal nervous system phenotype J:88826
open neural tube J:88826
respiratory distress J:88826
short frontal bone J:88826
short maxilla J:88826
short nasal bone J:88826
short snout J:88826
small orbits J:88826
wide frontal bone J:88826
Tfap2atm1Jae/Tfap2a+
involves: 129P/Ola * 129S4/SvJae 		abnormal cranium morphology J:76797
abnormal middle ear ossicle morphology J:76797
abnormal neurocranium morphology J:76797
absent interparietal bone J:76797
absent nasal bone J:76797
absent parietal bone J:76797
exencephaly J:76797
open neural tube J:76797
pup cannibalization J:76797
short mandible J:76797
short maxilla J:76797
normal skeleton phenotype J:76797
small frontal bone J:76797
small zygomatic bone J:76797
Tfap2atm1Jae/Tfap2atm1Jae
either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) 		abnormal apoptosis J:33032
abnormal axial skeleton morphology J:33032
abnormal cranial ganglia morphology J:33032
abnormal cranium morphology J:33032
abnormal forebrain morphology J:33032
abnormal lens vesicle development J:33032
abnormal neural fold elevation formation J:33032
abnormal thoracic cage morphology J:33032
abnormal ventral body wall morphology J:33032
absent outer ear J:33032
absent radius J:33032
absent sternum J:33032
acrania J:33032
anophthalmia J:33032
cranioschisis J:33032
exencephaly J:33032
incomplete rostral neuropore closure J:33032
midline facial cleft J:33032
perinatal lethality, complete penetrance J:33032
scoliosis J:33032
small trigeminal ganglion J:33032
splayed ribs J:33032
Tfap2atm1Will/Tfap2a+
involves: Black Swiss 		normal hearing/vestibular/ear phenotype J:90701
Tfap2atm1Will/Tfap2atm1Will
involves: Black Swiss 		abnormal adrenal gland secretion J:81338
abnormal aortic arch morphology J:73813
abnormal cell death J:33031
abnormal cochlear ganglion morphology J:33031
abnormal cornea morphology J:52402
abnormal cranial nerve morphology J:33031
abnormal cranium morphology J:33031
abnormal dorsal-ventral axis patterning J:33031
abnormal facial nerve morphology J:33031
abnormal glossopharyngeal ganglion morphology J:33031
abnormal head morphology J:33031
abnormal lens induction J:52402
abnormal lens morphology J:52402
abnormal lens vesicle development J:52402
abnormal mandible morphology J:33031
abnormal neurocranium morphology J:33031
abnormal optic fissure closure J:52402
abnormal optic stalk morphology J:52402
abnormal retina pigment epithelium morphology J:52402
abnormal truncus arteriosus septation J:73813
abnormal vagus ganglion morphology J:33031
abnormal vestibular ganglion morphology J:33031
absent clavicle J:33031
absent eyelids J:52402
absent maxilla J:33031
absent middle ear ossicles J:33031
absent mouth J:33031
absent oculomotor nerve J:33031
absent outer ear J:33031
absent pericardium J:73813
absent radius J:33031
absent retina ganglion layer J:52402
absent snout J:33031
absent sternum J:33031
absent tympanic ring J:33031
anencephaly J:33031
aniridia J:52402
anophthalmia J:52402
decreased body size J:33031
double outlet right ventricle J:73813
normal embryo phenotype J:33031
normal endocrine/exocrine gland phenotype J:81338
exencephaly J:33031
interrupted aortic arch J:73813
interrupted aortic arch, type b J:73813
perinatal lethality, complete penetrance J:33031
persistent truncus arteriosus J:73813
retroesophageal right subclavian artery J:73813
scoliosis J:33031
normal skeleton phenotype J:33031
small lens J:52402
small trigeminal ganglion J:33031
thoracoabdominoschisis J:33031
Tfap2atm1Will/Tfap2atm2.1Will
involves: 129S1/Sv * Black Swiss 		abnormal craniofacial development J:217408
abnormal facial morphology J:217408
abnormal lateral nasal prominence morphology J:217408
abnormal maxilla morphology J:217408
abnormal maxillary prominence morphology J:217408
abnormal medial nasal prominence morphology J:217408
abnormal nasal pit morphology J:217408
abnormal neural tube closure J:217408
abnormal premaxilla morphology J:217408
abnormal secondary palate morphology J:217408
cleft palate J:217408
exencephaly J:217408
facial cleft J:217408
perinatal lethality J:217408
polydactyly J:217408
Tfap2atm2.1Will/Tfap2atm2.1Will
involves: 129S1/Sv * Black Swiss 		no abnormal phenotype detected J:217408
Tfap2atm2Will/Tfap2atm2Will
involves: 129 * Black Swiss 		no abnormal phenotype detected J:88826
Tfap2atm2Will/Tfap2atm2Will
HhatTg(TFAP2A-cre)1Will/0
Not Specified 		abnormal blood vessel morphology J:88829
abnormal frontonasal suture morphology J:88829
abnormal nasal bone morphology J:88829
abnormal nasal septum cartilage morphology J:88829
abnormal neurocranium morphology J:88829
normal limbs/digits/tail phenotype J:88829
malocclusion J:88829
ocular hypertelorism J:88829
short frontal bone J:88829
short nasal bone J:88829
short snout J:88829
Tfap2atm3Will/Tfap2atm3Will
involves: 129S1/Sv * Black Swiss 		polydactyly J:128903
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory