Tfap2b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tfap2b
transcription factor AP-2 beta
MGI:104672

69 phenotypes from 6 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tfap2b^em1Fenli/Tfap2b^em1Fenli involves: C57BL/6	abnormal fetal ductus arteriosus morphology	J:278067
	abnormal kidney morphology	J:278067
	abnormal vascular smooth muscle physiology	J:278067
	normal craniofacial phenotype	J:278067
	dilated renal tubule	J:278067
	kidney cyst	J:278067
	kidney vascular congestion	J:278067
	normal limbs/digits/tail phenotype	J:278067
	neonatal lethality, complete penetrance	J:278067
	patent ductus arteriosus	J:278067
Tfap2b^em1Sleep/Tfap2b⁺ C57BL/6J-Tfap2b^em1Sleep	abnormal circadian sleep/wake cycle	J:297685
Tfap2b^em1Sleep/Tfap2b⁺ C57BL/6J-Tfap2b^em1Sleep	abnormal non-rapid eye movement sleep pattern	J:297685
Tfap2b^em1Sleep/Tfap2b^em1Sleep C57BL/6J-Tfap2b^em1Sleep	normal embryo phenotype	J:297685
Tfap2b^em1Sleep/Tfap2b^em1Sleep C57BL/6J-Tfap2b^em1Sleep	normal mortality/aging	J:297685
Tfap2b^em2Sleep/Tfap2b⁺ C57BL/6J-Tfap2b^em2Sleep	abnormal circadian sleep/wake cycle	J:297685
	abnormal non-rapid eye movement sleep pattern	J:297685
	normal behavior/neurological phenotype	J:297685
	increased frequency of paradoxical sleep	J:297685
Tfap2b^em2Sleep/Tfap2b^em2Sleep C57BL/6J-Tfap2b^em2Sleep	prenatal lethality, complete penetrance	J:297685
Tfap2b^{tm1b(EUCOMM)Wtsi}/Tfap2b⁺ C57BL/6N-Tfap2b^{tm1b(EUCOMM)Wtsi}/Ieg	abnormal optic disk morphology	J:211773
	increased grip strength	J:211773
	iris synechia	J:211773
Tfap2b^{tm1b(EUCOMM)Wtsi}/Tfap2b⁺ involves: C57BL/6N * DBA/2	abnormal circadian sleep/wake cycle	J:297685
	abnormal non-rapid eye movement sleep pattern	J:297685
	normal behavior/neurological phenotype	J:297685
Tfap2b^{tm1b(EUCOMM)Wtsi}/Tfap2b^{tm1b(EUCOMM)Wtsi} C57BL/6N-Tfap2b^{tm1b(EUCOMM)Wtsi}/Ieg	preweaning lethality, complete penetrance	J:211773
Tfap2b^tm1Rbu/Tfap2b⁺ involves: 129S1/Sv * 129X1/SvJ	patent ductus arteriosus	J:175832
Tfap2b^tm1Rbu/Tfap2b⁺ involves: 129S1/Sv * 129X1/SvJ	postaxial polydactyly	J:175832
Tfap2b^tm1Rbu/Tfap2b^tm1Rbu 129P2.129-Tfap2b^tm1Rbu	abnormal ion homeostasis	J:83000
	abnormal kidney physiology	J:83000
	decreased circulating calcium level	J:83000
	decreased urine calcium level	J:83000
	decreased urine osmolality	J:83000
	dilated proximal convoluted tubule	J:83000
	increased blood urea nitrogen level	J:83000
	increased circulating creatinine level	J:83000
	increased circulating parathyroid hormone level	J:83000
	increased circulating phosphate level	J:83000
	kidney cyst	J:83000
	muscle spasm	J:83000
	polydactyly	J:83000
	postnatal growth retardation	J:83000
	postnatal lethality, complete penetrance	J:83000
	scaly skin	J:83000
	tremors	J:83000
Tfap2b^tm1Rbu/Tfap2b^tm1Rbu involves: 129S1/Sv * 129X1/SvJ	abnormal pulmonary alveolar system morphology	J:175832
	congestive heart failure	J:175832
	neonatal lethality, incomplete penetrance	J:175832
	patent ductus arteriosus	J:175832
	postaxial polydactyly	J:175832
	pulmonary vascular congestion	J:175832
Tfap2b^tm1Rbu/Tfap2b^tm1Rbu involves: 129S1/Sv * 129X1/SvJ * C57BL/6	increased kidney apoptosis	J:42260
	increased renal tubule apoptosis	J:42260
	kidney cyst	J:42260
	neonatal lethality, complete penetrance	J:42260
	small kidney	J:42260
Tfap2b^tm1Rbu/Tfap2b^tm2Will H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J	abnormal ciliary body morphology	J:234170
	abnormal cornea epithelium morphology	J:234170
	abnormal cornea morphology	J:234170
	abnormal cornea stroma morphology	J:234170
	abnormal eye anterior chamber morphology	J:234170
	abnormal eye morphology	J:234170
	abnormal iridocorneal angle	J:234170
	abnormal lens epithelium morphology	J:234170
	abnormal optic disk morphology	J:234170
	absent cornea endothelium	J:234170
	anterior iris synechia	J:234170
	anterior subcapsular cataract	J:234170
	cornea vascularization	J:234170
	decreased amacrine cell number	J:234170
	decreased cornea epithelium thickness	J:234170
	decreased total retina thickness	J:234170
	eye opacity	J:234170
	fused cornea and lens	J:234170
	gliosis	J:234170
	ocular hypertension	J:234170
	optic nerve atrophy	J:234170
	optic nerve cupping	J:234170
	optic nerve degeneration	J:234170
	retina ganglion cell degeneration	J:234170
	thin retina inner plexiform layer	J:234170

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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