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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hgs
HGF-regulated tyrosine kinase substrate
MGI:104681
66 phenotypes from 8 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
HgsTg(Tyr)2400A-1Ove/HgsTg(Tyr)2400A-1Ove
FVB/N-HgsTg(Tyr)2400A-1Ove 		embryonic lethality between implantation and somite formation J:175597
Hgstm1a(EUCOMM)Wtsi/Hgs+
Not Specified 		abnormal coping response J:165965
Hgstm1b(EUCOMM)Wtsi/Hgstm1b(EUCOMM)Wtsi
C57BL/6N-Hgstm1b(EUCOMM)Wtsi/Ieg 		preweaning lethality, complete penetrance J:211773
Hgstm1Sor/Hgstm1Sor
either: 129/Sv-Hgstm1Sor or B6.129-Hgstm1Sor or (involves: 129/Sv * 129S4/SvJae * C57BL/6J) 		abnormal embryonic tissue morphology J:55580
abnormal extraembryonic tissue morphology J:55580
abnormal rostral-caudal axis patterning J:55580
abnormal somite development J:55580
absent foregut J:55580
cardia bifida J:55580
decreased embryo size J:55580
dilated allantois J:55580
embryonic lethality during organogenesis, complete penetrance J:55580
failure of chorioallantoic fusion J:55580
failure of initiation of embryo turning J:55580
open neural tube J:55580
wavy neural tube J:55580
Hgstm1Sug/Hgstm1Sug
involves: 129S4/SvJae * C57BL/6J 		decreased embryo size J:65990
embryonic lethality, complete penetrance J:65990
failure of initiation of embryo turning J:65990
Hgstm1Tkh/Hgstm1Tkh
involves: 129S4/SvJae * C57BL/6 		abnormal cell physiology J:97764
embryonic lethality during organogenesis, complete penetrance J:97764
Hgstm2Tkh/Hgstm2Tkh
Tg(Syn1-cre)671Jxm/0
involves: C57BL/6 * CBA * SJL 		abnormal hippocampus pyramidal cell morphology J:141391
behavioral despair J:141391
decreased vertical activity J:141391
impaired passive avoidance behavior J:141391
increased neuron apoptosis J:141391
infertility J:141391
postnatal growth retardation J:141391
slow postnatal weight gain J:141391
Hgstn/Hgstn
B6.C3-Hgstn 		abnormal axon morphology J:5025
abnormal brain development J:5025
abnormal cerebellar cortex morphology J:5025
abnormal CNS glial cell morphology J:5025
abnormal medulla oblongata morphology J:5025
abnormal motor coordination/balance J:5025
abnormal myelin sheath morphology J:5025
abnormal resting posture J:5025
abnormal spinal cord grey matter morphology J:5025
abnormal spinal cord white matter morphology J:5025
abnormal spinal nerve morphology J:5025
abnormal vertebral column morphology J:5025
abnormal vertebral spinous process morphology J:5025
axonal dystrophy J:5025
cachexia J:5025
decreased body height J:5025
decreased body size J:5025
decreased corticospinal tract size J:5025
decreased hindbrain size J:5025
decreased midbrain size J:5025
decreased neuron number J:5025
decreased pons size J:5025
decreased spinal cord size J:5025
decreased trabecular bone thickness J:5025
impaired balance J:5025
impaired swimming J:5025
increased stereotypic behavior J:5025
jerky movement J:5025
muscular atrophy J:5025
opisthotonus J:5025
paralysis J:5025
postnatal growth retardation J:5025
premature death J:5025
Purkinje cell degeneration J:5025
short vertebral body J:5025
small cerebellum J:5025
thin cerebellar granule layer J:5025
Hgstn/Hgstn
C3H/HeJ-Hgstn 		abnormal posture J:13411
abnormal stationary movement J:13411
bradykinesia J:13411
normal hearing/vestibular/ear phenotype J:13411
premature death J:13411
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory