Twist2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Twist2
twist basic helix-loop-helix transcription factor 2
MGI:104685

49 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Twist2^tm1(cre)Dor/Twist2⁺ involves: 129X1/SvJ	no abnormal phenotype detected	J:90391
Twist2^tm1(cre)Dor/Twist2^tm1(cre)Dor involves: 129/Sv * 129X1/SvJ	abnormal brown fat cell morphology	J:81485
	abnormal hair follicle morphology	J:81485
	abnormal hepatocyte morphology	J:81485
	abnormal interleukin level	J:81485
	abnormal interscapular fat pad morphology	J:81485
	abnormal osteoblast differentiation	J:90056
	abnormal skeletal muscle morphology	J:81485
	abnormal spleen morphology	J:81485
	abnormal spleen white pulp morphology	J:81485
	abnormal thymus cortex morphology	J:81485
	abnormal thymus medulla morphology	J:81485
	abnormal thymus morphology	J:81485
	abnormal tumor necrosis factor level	J:81485
	absent subcutaneous adipose tissue	J:81485
	cachexia	J:81485
	decreased hair follicle number	J:81485
	decreased liver glycogen level	J:81485
	decreased skeletal muscle glycogen level	J:81485
	decreased total body fat amount	J:81485
	dystonia	J:81485
	epidermal atrophy	J:81485
	hyperkeratosis	J:81485
	hypoglycemia	J:81485
	postnatal lethality, incomplete penetrance	J:81485
	sparse hair	J:81485
	thin dermal layer	J:81485
	thin skin	J:81485
	thymus atrophy	J:81485
Twist2^tm1(cre)Dor/Twist2^tm1(cre)Dor involves: 129X1/SvJ * C57BL/6	abnormal craniofacial morphology	J:169191
	abnormal dermal layer morphology	J:169191
	abnormal eye morphology	J:169191
	abnormal hair growth	J:169191
	abnormal head morphology	J:169191
	abnormal skin adnexa morphology	J:169191
	absent Meibomian glands	J:169191
	alopecia	J:169191
	decreased subcutaneous adipose tissue amount	J:169191
	loss of eyelid cilia	J:169191
	lowered ear position	J:169191
	Meibomian gland hypoplasia	J:169191
	narrow snout	J:169191
	skin lesions	J:169191
	sparse hair	J:169191
	thin skin	J:169191
Twist2^{tm1.1(cre)Dor}/Twist2⁺ involves: 129X1/SvJ * C57BL/6	no abnormal phenotype detected	J:81485
Twist2^{tm1.1(KOMP)Vlcg}/Twist2⁺ C57BL/6N-Twist2^{tm1.1(KOMP)Vlcg}/Ucd	abnormal lung morphology	J:211773
	abnormal testis morphology	J:211773
	enlarged lung	J:211773
	increased lung weight	J:211773
	small testis	J:211773
Twist2^{tm1.1(KOMP)Vlcg}/Twist2^{tm1.1(KOMP)Vlcg} C57BL/6N-Twist2^{tm1.1(KOMP)Vlcg}/Ucd	preweaning lethality, incomplete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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