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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Twist2
twist basic helix-loop-helix transcription factor 2
MGI:104685
50 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Twist2tm1(cre)Dor/Twist2+
involves: 129X1/SvJ 		no abnormal phenotype detected J:90391
Twist2tm1(cre)Dor/Twist2tm1(cre)Dor
involves: 129/Sv * 129X1/SvJ 		abnormal brown fat cell morphology J:81485
abnormal hair follicle morphology J:81485
abnormal hepatocyte morphology J:81485
abnormal interleukin level J:81485
abnormal interscapular fat pad morphology J:81485
abnormal osteoblast differentiation J:90056
abnormal skeletal muscle morphology J:81485
abnormal spleen morphology J:81485
abnormal spleen white pulp morphology J:81485
abnormal thymus cortex morphology J:81485
abnormal thymus medulla morphology J:81485
abnormal thymus morphology J:81485
abnormal tumor necrosis factor level J:81485
absent subcutaneous adipose tissue J:81485
cachexia J:81485
decreased hair follicle number J:81485
decreased liver glycogen level J:81485
decreased skeletal muscle glycogen level J:81485
decreased total body fat amount J:81485
dystonia J:81485
epidermal atrophy J:81485
hyperkeratosis J:81485
hypoglycemia J:81485
postnatal lethality, incomplete penetrance J:81485
sparse hair J:81485
thin dermal layer J:81485
thin skin J:81485
thymus atrophy J:81485
Twist2tm1(cre)Dor/Twist2tm1(cre)Dor
involves: 129X1/SvJ * C57BL/6 		abnormal craniofacial morphology J:169191
abnormal dermal layer morphology J:169191
abnormal eye morphology J:169191
abnormal hair growth J:169191
abnormal head morphology J:169191
abnormal skin adnexa morphology J:169191
absent Meibomian glands J:169191
alopecia J:169191
decreased subcutaneous adipose tissue amount J:169191
loss of eyelid cilia J:169191
lowered ear position J:169191
Meibomian gland hypoplasia J:169191
narrow snout J:169191
skin lesions J:169191
sparse hair J:169191
thin skin J:169191
Twist2tm1.1(cre)Dor/Twist2+
involves: 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:81485
Twist2tm1.1(KOMP)Vlcg/Twist2+
C57BL/6N-Twist2tm1.1(KOMP)Vlcg/Ucd 		abnormal heart morphology J:211773
abnormal lung morphology J:211773
abnormal testis morphology J:211773
enlarged heart J:211773
enlarged lung J:211773
small testis J:211773
Twist2tm1.1(KOMP)Vlcg/Twist2tm1.1(KOMP)Vlcg
C57BL/6N-Twist2tm1.1(KOMP)Vlcg/Ucd 		preweaning lethality, incomplete penetrance J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory