Crkl Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Crkl
v-crk avian sarcoma virus CT10 oncogene homolog-like
MGI:104686

19 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Crk^tm1Cur/Crk^tm1Cur Crkl^tm1Cur/Crkl^tm1Cur Tg(Nes-cre)1Kln/0 involves: 129S/SvEv * C57BL/6 * SJL	abnormal cerebellar foliation	J:143049
	abnormal cerebellum development	J:143049
	abnormal cerebral cortex morphology	J:143049
	abnormal cerebral cortex pyramidal cell morphology	J:143049
	abnormal cortical plate morphology	J:143049
	abnormal dentate gyrus morphology	J:143049
	abnormal hippocampus morphology	J:143049
	abnormal hippocampus pyramidal cell layer	J:143049
	abnormal Purkinje cell dendrite morphology	J:143049
	decreased body weight	J:143049
	ectopic cerebellar granule cells	J:143049
	postnatal growth retardation	J:143049
	postnatal lethality	J:143049
	small cerebellum	J:143049
	thin cerebellar molecular layer	J:143049
Crkl^tm1Hkp/Crkl^tm1Hkp Tg(BCR/ABL)623Hkp/? involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * CBA	increased B cell derived lymphoma incidence	J:76680
	increased leukemia incidence	J:76680
	perinatal lethality, incomplete penetrance	J:76680
	premature death	J:76680

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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