Col4a3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Col4a3
collagen, type IV, alpha 3
MGI:104688

53 phenotypes from 4 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Col4a3^tm1.1Rkl/Col4a3⁺ involves: C57BL/6	abnormal renal glomerulus morphology	J:167404
	glomerulonephritis	J:167404
	increased circulating creatinine level	J:167404
	increased urine protein level	J:167404
	kidney atrophy	J:167404
	podocyte foot process effacement	J:167404
	premature death	J:167404
	renal interstitial fibrosis	J:167404
Col4a3^{tm1b(EUCOMM)Wtsi}/Col4a3^{tm1b(EUCOMM)Wtsi} C57BL/6N-Col4a3^{tm1b(EUCOMM)Wtsi}/H	decreased basophil cell number	J:211773
	decreased circulating amylase level	J:211773
	decreased hemoglobin content	J:211773
	decreased lymphocyte cell number	J:211773
	increased kidney weight	J:211773
	increased large unstained cell number	J:211773
	increased neutrophil cell number	J:211773
	irregularly shaped pupil	J:211773
Col4a3^tm1Dec/Col4a3^tm1Dec 129-Col4a3^tm1Dec/J	abnormal renal glomerulus basement membrane morphology	J:158731
	abnormal renal glomerulus morphology	J:158731
	albuminuria	J:158731
	decreased survivor rate	J:158731
	glomerulonephritis	J:158731
	glomerulosclerosis	J:158731
	glomerulus hemorrhage	J:158731
	increased blood urea nitrogen level	J:158731
	increased circulating creatinine level	J:158731
	increased renal glomerulus basement membrane thickness	J:158731
	increased urine protein level	J:158731
	kidney failure	J:158731
	premature death	J:158731
	renal cast	J:158731
	renal interstitial fibrosis	J:158731
	renal tubule atrophy	J:158731
Col4a3^tm1Dec/Col4a3^tm1Dec 129X1/SvJ-Col4a3^tm1Dec	abnormal cochlear basement membrane morphology	J:91619, J:98449
	abnormal stria vascularis morphology	J:98449
	abnormal stria vascularis vasculature morphology	J:91619
	increased or absent threshold for auditory brainstem response	J:91619
	sensorineural hearing loss	J:91619
Col4a3^tm1Dec/Col4a3^tm1Dec B6.129X1-Col4a3^tm1Dec	abnormal renal glomerulus basement membrane thickness	J:167404
	glomerulonephritis	J:167404
	increased circulating creatinine level	J:167404
	increased urine protein level	J:167404
	podocyte foot process effacement	J:167404
	premature death	J:167404
	renal interstitial fibrosis	J:167404
	renal tubule atrophy	J:167404
Col4a3^tm1Dec/Col4a3^tm1Dec involves: 129X1/SvJ * C57BL/6	abnormal cochlear basement membrane morphology	J:91619
	abnormal glomerular capillary morphology	J:37963
	abnormal lens morphology	J:37963
	abnormal membranous labyrinth morphology	J:91619
	abnormal podocyte morphology	J:37963
	abnormal renal glomerulus basement membrane thickness	J:37963
	abnormal stria vascularis morphology	J:91619
	abnormal stria vascularis vasculature morphology	J:91619
	abnormal strial marginal cell morphology	J:91619
	albuminuria	J:37963
	expanded mesangial matrix	J:37963
	glomerulonephritis	J:37963
	granular kidney	J:37963
	hematuria	J:37963
	increased blood urea nitrogen level	J:37963
	increased mesangial cell number	J:37963
	pale kidney	J:37963
	podocyte foot process effacement	J:37963, J:91619
	podocyte microvillus transformation	J:37963
	premature death	J:37963
	renal glomerulus fibrosis	J:37963
	small kidney	J:37963
Col4a3^tm1Jhm/Col4a3^tm1Jhm involves: 129S1/Sv * 129X1/SvJ	abnormal glomerular capillary morphology	J:37017
	abnormal kidney morphology	J:37017
	abnormal podocyte foot process morphology	J:207595
	abnormal renal glomerulus basement membrane morphology	J:37017, J:207595
	albuminuria	J:37017
	decreased body weight	J:37017
	decreased renal glomerular filtration rate	J:37017
	expanded mesangial matrix	J:37017
	glomerular crescent	J:37017
	glomerulonephritis	J:37017
	glomerulosclerosis	J:37017, J:207595
	increased blood urea nitrogen level	J:37017
	increased circulating creatinine level	J:37017
	increased or absent threshold for auditory brainstem response	J:37017
	increased renal glomerulus basement membrane thickness	J:37017, J:207595
	increased urine protein level	J:37017, J:207595
	kidney failure	J:37017
	lethargy	J:37017
	polyuria	J:37017
	premature death	J:37017, J:207595
	renal cast	J:207595
	renal tubule atrophy	J:37017
	small kidney	J:37017
	uremia	J:37017

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