Col4a3 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Col4a3
collagen, type IV, alpha 3
MGI:104688

22 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Col4a3^tm1Dec/Col4a3^tm1Dec Itga1^tm1Gdnr/Itga1^tm1Gdnr involves: 129S4/SvJae * 129X1/SvJ * BALB/c	abnormal kidney morphology	J:71378
	abnormal renal glomerulus basement membrane morphology	J:91620
	increased circulating total protein level	J:91620
	kidney failure	J:91620
	tubular nephritis	J:71378
Col4a3^tm1Dec/Col4a3^tm1Dec Sostdc1^tm1Myan/Sostdc1^tm1Myan involves: 129X1/SvJ	albuminuria	J:158731
	decreased systemic arterial systolic blood pressure	J:158731
	extended life span	J:158731
	glomerulonephritis	J:158731
	glomerulosclerosis	J:158731
	increased blood urea nitrogen level	J:158731
	increased circulating creatinine level	J:158731
	renal cast	J:158731
	renal interstitial fibrosis	J:158731
	renal tubule atrophy	J:158731
Col4a3^tm1Jhm/Col4a3^tm1Jhm Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺ Tg(tetO-COL4A3/Col4a3)#aJhm/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	increased renal glomerulus basement membrane thickness	J:207595
	normal renal/urinary system phenotype	J:207595
Col4a3^tm1Jhm/Col4a3^tm1Jhm Lamb2^em1Jhm/Lamb2⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J	abnormal kidney morphology	J:280129
	abnormal renal glomerulus basement membrane morphology	J:280129
	albuminuria	J:280129
	glomerular crescent	J:280129
	glomerulosclerosis	J:280129
	increased blood urea nitrogen level	J:280129
	kidney failure	J:280129
	podocyte foot process effacement	J:280129
	premature death	J:280129
Col4a3^tm1Jhm/Col4a3^tm1Jhm Lamb2^em1Jhm/Lamb2^em1Jhm involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J	abnormal renal glomerulus basement membrane morphology	J:280129
	glomerulosclerosis	J:280129
	podocyte foot process effacement	J:280129
Col4a3^tm1Jhm/Col4a3^tm1Jhm Mmp9^tm1Tvu/Mmp9^tm1Tvu involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ	abnormal renal glomerulus basement membrane morphology	J:63137
	glomerulonephritis	J:63137
	increased renal glomerulus basement membrane thickness	J:63137
Col4a3^tm1Jhm/Col4a3^tm1Jhm Tg(Nphs1-rtTA3G)8Jhm/0 Tg(tetO-COL4A3/Col4a3)#aJhm/0 involves: 129S1/Sv 129X1/SvJ * C57BL/6 * CBA	abnormal podocyte foot process morphology	J:207595
	abnormal renal glomerulus basement membrane morphology	J:207595
	increased renal glomerulus basement membrane thickness	J:207595
	normal mortality/aging	J:207595
	normal renal/urinary system phenotype	J:207595

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24