Scnn1b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Scnn1b
sodium channel, nonvoltage-gated 1 beta
MGI:104696

32 phenotypes from 7 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Scnn1b^tm1.1Hum/Scnn1b^tm1.1Hum involves: 129P2/OlaHsd	no abnormal phenotype detected	J:144725
Scnn1b^tm1.1Ipt/Scnn1b⁺ involves: 129P2/OlaHsd * C57BL/6J * FVB/N	abnormal digestive system physiology	J:59840
	abnormal kidney morphology	J:59840
	decreased circulating aldosterone level	J:59840
	hypervolemia	J:59840
	hypokalemia	J:59840
	increased systemic arterial systolic blood pressure	J:59840
Scnn1b^tm1.1Ipt/Scnn1b^tm1.1Ipt involves: 129P2/OlaHsd * C57BL/6J * FVB/N	abnormal digestive system physiology	J:59840
	abnormal kidney morphology	J:59840
	alkalosis	J:59840
	cardiac hypertrophy	J:59840
	decreased circulating aldosterone level	J:59840
	hypervolemia	J:59840
	hypokalemia	J:59840
	salt-sensitive hypertension	J:59840
Scnn1b^tm1.2Hum/Scnn1b^tm1.2Hum involves: 129P2/OlaHsd * FVB/N	postnatal lethality, complete penetrance	J:144725
Scnn1b^{tm1b(EUCOMM)Hmgu}/Scnn1b⁺ C57BL/6N-Scnn1b^{tm1b(EUCOMM)Hmgu}/Cnrm	abnormal pelvic girdle bone morphology	J:211773
	increased circulating fructosamine level	J:211773
Scnn1b^{tm1b(EUCOMM)Hmgu}/Scnn1b^{tm1b(EUCOMM)Hmgu} C57BL/6N-Scnn1b^{tm1b(EUCOMM)Hmgu}/Cnrm	preweaning lethality, complete penetrance	J:211773
Scnn1b^tm1Ipt/Scnn1b^tm1Ipt involves: 129P2/OlaHsd * C57BL/6J	no abnormal phenotype detected	J:53057
Scnn1b^tm1Wsh/Scnn1b^tm1Wsh involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal urine homeostasis	J:53058
	decreased body weight	J:53058
	decreased circulating sodium level	J:53058
	increased circulating aldosterone level	J:53058
	increased circulating chloride level	J:53058
	increased circulating potassium level	J:53058
	neonatal lethality, complete penetrance	J:53058
	normal respiratory system phenotype	J:53058
Tg(Scgb1a1-Scnn1b)6608Bouc/0 B6.Cg-Tg(Scgb1a1-Scnn1b)6608Bouc	abnormal mucociliary clearance	J:191673
	abnormal respiratory mucosa goblet cell morphology	J:191673
	abnormal respiratory system physiology	J:191673
	emphysema	J:191673
	postnatal lethality, incomplete penetrance	J:191673
	pulmonary epithelial necrosis	J:191673
	respiratory system inflammation	J:191673
Tg(Scgb1a1-Scnn1b)6608Bouc/0 C.Cg-Tg(Scgb1a1-Scnn1b)6608Bouc	abnormal mucociliary clearance	J:191673
	abnormal respiratory mucosa goblet cell morphology	J:191673
	abnormal respiratory system physiology	J:191673
	emphysema	J:191673
	postnatal lethality, incomplete penetrance	J:191673
	pulmonary epithelial necrosis	J:191673
	respiratory system inflammation	J:191673
Tg(Scgb1a1-Scnn1b)6608Bouc/0 involves: C3H * C57BL/6	abnormal mucociliary clearance	J:91139
	abnormal respiratory mucosa goblet cell morphology	J:91139
	abnormal respiratory system physiology	J:91139
	bronchitis	J:91139
	postnatal lethality	J:91139
	respiratory distress	J:91139

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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