Cdkn2b Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cdkn2b
cyclin dependent kinase inhibitor 2B
MGI:104737

25 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn Cdkn2b^tm2Brn/Cdkn2b^tm2Brn involves: 129P2/OlaHsd * FVB/N	increased incidence of tumors by chemical induction	J:125189
	increased skin tumor incidence	J:125189
	normal neoplasm	J:125189
Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd involves: 129S1/Sv * C57BL/6	abnormal cell physiology	J:63299
	abnormal Langerhans cell morphology	J:63299
	abnormal lymphocyte morphology	J:63299
	abnormal mammary gland morphology	J:63299
	abnormal testis morphology	J:63299
	dilated rete testis	J:63299
	enlarged spleen	J:63299
	enlarged testis	J:63299
	extramedullary hematopoiesis	J:63299
	increased fibroblast proliferation	J:63299
	increased lymphoma incidence	J:63299
	increased pituitary adenoma incidence	J:63299
	increased sarcoma incidence	J:63299
	increased testis tumor incidence	J:63299
	increased tumor incidence	J:63299
	kidney cyst	J:63299
	lymph node hyperplasia	J:63299
	lymphoid hyperplasia	J:63299
	pancreas cyst	J:63299
	seminiferous tubule degeneration	J:63299
Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd Pbx1^tm1Koss/Pbx1^tm1Koss Nkx2-5^tm2(cre)Rph/Nkx2-5⁺ involves: 129P2/OlaHsd * 129S1/Sv	abnormal spleen mesenchyme morphology	J:184521
	abnormal spleen morphology	J:184521

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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