Cdkn2a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cdkn2a
cyclin dependent kinase inhibitor 2A
MGI:104738

77 phenotypes from 17 alleles in 19 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cdkn2a^em1Cjs/Cdkn2a^em1Cjs B6.Cg-Cdkn2a^em1Cjs	increased acute lymphoblastic leukemia incidence	J:244260
	increased testis weight	J:244260
	normal reproductive system phenotype	J:244260
	normal vision/eye phenotype	J:244260
Cdkn2a^em2Cjs/Cdkn2a^em2Cjs C57BL/6-Cdkn2a^em2Cjs	abnormal spermatocyte morphology	J:244260
	binocular blindness	J:244260
	normal neoplasm	J:244260
	oligozoospermia	J:244260
	persistent hyperplastic primary vitreous	J:244260
	retina detachment	J:244260
Cdkn2a^Pctr1-DBA/2N/? involves: BALB/cAnPt * DBA/2N	decreased tumor incidence	J:16958
Cdkn2a^tm1(GFP)Cjs/Cdkn2a^tm1(GFP)Cjs involves: 129S1/Sv * C57BL/6	increased gastrointestinal stromal tumor incidence	J:87339
	increased hemangiosarcoma incidence	J:87339
	increased histiocytic sarcoma incidence	J:87339
	increased incidence of tumors by ionizing radiation induction	J:87339
	increased lymphoma incidence	J:87339
	increased sarcoma incidence	J:87339
	increased tumor incidence	J:87339
Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn involves: 129P2/OlaHsd * FVB/N	decreased incidence of tumors by chemical induction	J:125189
	normal neoplasm	J:71393
Cdkn2a^tm1.1Gsu/Cdkn2a^tm1.1Gsu Tg(Pdx1-cre)6Tuv/0 involves: 129S4/SvJaeSor * C57BL/6J * FVB/N	normal neoplasm	J:198619
Cdkn2a^{tm1a(EUCOMM)Wtsi}/Cdkn2a^{tm1a(EUCOMM)Wtsi} C57BL/6N-Cdkn2a^{tm1a(EUCOMM)Wtsi}/Wtsi	abnormal lens morphology	J:175295
	cataract	J:175295
Cdkn2a^tm1Cjs/Cdkn2a⁺ involves: 129X1/SvJ * C57BL/6 * NIH/OlaHsd	increased carcinoma incidence	J:93298
	increased incidence of tumors by chemical induction	J:93298
	increased papilloma incidence	J:93298
Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs involves: 129X1/SvJ	blindness	J:147752
	decreased testis weight	J:147752
	oligozoospermia	J:147752
	testicular atrophy	J:147752
Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs involves: 129X1/SvJ * C57BL/6	abnormal cell physiology	J:44427
	abnormal lens capsule morphology	J:75215
	abnormal lens morphology	J:75215
	abnormal retina ganglion layer morphology	J:75215
	abnormal retina inner nuclear layer morphology	J:75215
	abnormal retina morphology	J:75215
	abnormal retina photoreceptor morphology	J:75215
	abnormal spermatocyte morphology	J:244260
	binocular blindness	J:244260
	decreased testis weight	J:244260
	increased acute lymphoblastic leukemia incidence	J:244260
	increased carcinoma incidence	J:44427
	increased fibroblast proliferation	J:44427
	increased fibrohistocytoma incidence	J:44427
	increased fibrosarcoma incidence	J:44427
	increased incidence of tumors by chemical induction	J:44427
	increased incidence of tumors by ionizing radiation induction	J:44427
	increased lymphoma incidence	J:44427
	increased T cell derived lymphoma incidence	J:44427
	increased tumor incidence	J:44427
	microphthalmia	J:75215
	oligozoospermia	J:244260
	persistent hyperplastic primary vitreous	J:75215, J:149526
	primary vitreous hyperplasia	J:101016
	retina detachment	J:75215, J:244260
	retina fold	J:75215
	normal vision/eye phenotype	J:149526
Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs involves: 129X1/SvJ * C57BL/6 * NIH/OlaHsd	increased carcinoma incidence	J:93298
	increased incidence of tumors by chemical induction	J:93298
	increased metastatic potential	J:93298
	increased papilloma incidence	J:93298
	increased squamous cell carcinoma incidence	J:93298
	increased tumor growth/size	J:93298
Cdkn2a^tm1Nesh/Cdkn2a^tm1Nesh involves: 129S6/SvEvTac * FVB/N	abnormal cell physiology	J:88365
	hindlimb paralysis	J:88365
	increased incidence of tumors by chemical induction	J:88365
	increased lung carcinoma incidence	J:88365
	increased osteosarcoma incidence	J:88365
	increased sarcoma incidence	J:88365
	increased small lymphocytic lymphoma incidence	J:88365
	increased tumor incidence	J:88365
	seizures	J:88365
Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp FVB.Cg-Cdkn2a^tm1Rdp	abnormal lens development	J:110215
	abnormal posterior eye segment morphology	J:110215
	abnormal retina neuronal layer morphology	J:110215
	abnormal retina photoreceptor morphology	J:110215
	cataract	J:110215
	microphthalmia	J:110215
	persistent hyperplastic primary vitreous	J:110215
	retina fold	J:110215
Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp involves: 129/Sv * C57BL/6 * C57BL/6J * SJL	abnormal cell physiology	J:72780
	abnormal keratinocyte physiology	J:72780
	abnormal skin physiology	J:72780
	delayed cellular replicative senescence	J:72780
	increased squamous cell carcinoma incidence	J:72780
Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp involves: 129/Sv * C57BL/6 * SJL	abnormal cell cycle	J:53805
	abnormal spleen morphology	J:53805
	abnormal spleen red pulp morphology	J:53805
	extramedullary hematopoiesis	J:53805
	increased B cell derived lymphoma incidence	J:53805
	increased cutaneous melanoma incidence	J:98545
	increased fibroblast proliferation	J:53805
	increased fibrosarcoma incidence	J:53805
	increased hemangiosarcoma incidence	J:53805
	increased sarcoma incidence	J:53805
	increased spleen white pulp amount	J:53805
	increased tumor incidence	J:53805
Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp involves: 129/Sv * C57BL/6J * FVB/N * SJL	abnormal cell physiology	J:88365
	decreased tumor-free survival time	J:88365
	increased lymphoma incidence	J:88365
	increased sarcoma incidence	J:88365
	increased tumor incidence	J:88365
Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp involves: 129/Sv * C57BL/6J * SJL	increased brain tumor incidence	J:163931
Cdkn2a^tm1Sxs/Cdkn2a^tm1Sxs involves: 129/Sv * C57BL/6	abnormal eye morphology	J:149526
	abnormal tumor incidence	J:149526
	primary vitreous hyperplasia	J:149526
Cdkn2a^tm2.1Brn/Cdkn2a^tm2.1Brn involves: 129P2/OlaHsd * FVB/N	increased carcinoma incidence	J:71393
	increased incidence of tumors by chemical induction	J:71393
	increased lymphoma incidence	J:71393
	increased melanoma incidence	J:71393
	increased metastatic potential	J:71393
	increased sarcoma incidence	J:71393
	increased tumor incidence	J:71393
Cdkn2a^tm2.1Rdp/Cdkn2a⁺ involves: 129S6/SvEvTac * FVB/N	increased tumor incidence	J:71394
Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp involves: 129S6/SvEvTac * FVB/N	increased CD4-positive, alpha-beta T cell number	J:71394
	increased CD8-positive, alpha-beta T cell number	J:71394
	increased double-positive T cell number	J:71394
	increased incidence of tumors by chemical induction	J:71394, J:88365
	increased lymphoma incidence	J:88365
	increased osteosarcoma incidence	J:88365
	increased sarcoma incidence	J:88365
	increased small lymphocytic lymphoma incidence	J:88365
	increased splenocyte proliferation	J:71394
	increased thymus weight	J:71394
	increased tumor incidence	J:71394, J:88365
	thymus hyperplasia	J:71394
Cdkn2a^tm3(cre)Cjs/Cdkn2a⁺ involves: 129S1/Sv * C57BL/6	male infertility	J:147752
Cdkn2a^tm3(cre)Cjs/Cdkn2a^tm4Cjs involves: 129S1/Sv * C57BL/6	abnormal lens morphology	J:147752
	abnormal retina morphology	J:147752
	blindness	J:147752
	microphthalmia	J:147752
	retina fold	J:147752
Cdkn2a^tm4Cjs/Cdkn2a^tm4Cjs involves: 129S1/Sv * C57BL/6	normal neoplasm	J:147752
Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp Tg(Pdx1-cre)89.1Dam/0 involves: C57BL/6 * CBA * FVB/N	normal neoplasm	J:87196
Tg(TTR-p19Cdkn2a)2Tvd/0 involves: C57BL/6J * DBA/2J	increased circulating glucose level	J:94077
	polydipsia	J:94077
	polyuria	J:94077
	reduced female fertility	J:94077

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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