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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ppara
peroxisome proliferator activated receptor alpha
MGI:104740
63 phenotypes from 7 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pparaem1Tyrb/Ppara+
C57BL/6J-Pparaem1Tyrb 		abnormal dendritic spine morphology J:313946
Pparaem1Tyrb/Pparaem1Tyrb
C57BL/6J-Pparaem1Tyrb 		abnormal dendritic spine morphology J:313946
decreased dendritic spine density J:313946
decreased prepulse inhibition J:313946
increased anxiety-related response J:313946
Pparatm1b(EUCOMM)Wtsi/Pparatm1b(EUCOMM)Wtsi
C57BL/6N-Pparatm1b(EUCOMM)Wtsi/BayMmucd 		abnormal coat appearance J:211773
abnormal skin coloration J:211773
Pparatm1Gonz/Pparatm1Gonz
129S4/SvJae-Pparatm1Gonz 		abnormal circulating glucose level J:72932
abnormal circulating HDL cholesterol level J:72185
abnormal circulating insulin level J:72932
abnormal circulating ketone body level J:56056
abnormal glucose homeostasis J:56056
abnormal myocardium layer morphology J:56056
enlarged liver J:56056
hepatic steatosis J:56056, J:72185
increased body weight J:72185
increased circulating cholesterol level J:72185
increased circulating free fatty acids level J:56056
increased gonadal fat pad weight J:72185
increased susceptibility to induced morbidity/mortality J:56056
insulin resistance J:72932
Pparatm1Gonz/Pparatm1Gonz
B6.129S4-Pparatm1Gonz 		abnormal circulating glucose level J:72932
abnormal circulating insulin level J:72932
hepatic steatosis J:72185
increased circulating triglyceride level J:72185
increased gonadal fat pad weight J:72185
Pparatm1Gonz/Pparatm1Gonz
involves: 129S4/SvJae 		abnormal cardiovascular system physiology J:63801
abnormal myocardial fiber morphology J:63801
abnormal myocardial fiber physiology J:63801
abnormal vascular endothelial cell morphology J:63801
cardiac fibrosis J:63801
cardiomyopathy J:63801
decreased circulating glucose level J:127793
decreased fatty acid oxidation J:176083
decreased systemic arterial systolic blood pressure J:63801
heart inflammation J:63801
hypotension J:63801
impaired adaptive thermogenesis J:176083
increased circulating cholesterol level J:127793
increased circulating free fatty acids level J:127793
increased circulating insulin level J:127793
normal integument phenotype J:109090
myocardial fiber degeneration J:63801
myocardium necrosis J:63801
Pparatm1Gonz/Pparatm1Gonz
involves: 129S4/SvJae * C57BL/6 		normal renal/urinary system phenotype J:244067
Pparatm1Gonz/Pparatm1Gonz
involves: 129S4/SvJae * C57BL/6J 		abnormal glucose homeostasis J:129848
improved glucose tolerance J:129848
increased insulin sensitivity J:129848
increased muscle cell glucose uptake J:129848
increased skeletal muscle triglyceride level J:129848
increased susceptibility to diet-induced obesity J:129848
Pparatm1Gonz/Pparatm1Gonz
involves: 129S4/SvJae * C57BL/6N 		abnormal epidermal layer morphology J:81021
abnormal epidermis stratum corneum morphology J:81021
abnormal hepatocyte morphology J:25516
abnormal myocardial fiber morphology J:50024
cardiomyopathy J:81834
decreased liver glycogen level J:50024
delayed wound healing J:71272
enlarged liver J:25516
hepatic steatosis J:25516, J:50024
hypoglycemia J:50024
increased susceptibility to induced morbidity/mortality J:50024
Pparatm1Gonz/Pparatm1Gonz
involves: C57BL/6 		abnormal epidermal layer morphology J:64345
abnormal keratinocyte differentiation J:64345
decreased keratohyalin granule number J:64345
thin epidermis stratum granulosum J:64345
Tg(Ckm-Ppara)HEDpk/0
involves: C57BL/6 * CBA 		abnormal glucose homeostasis J:129848
decreased abdominal adipose tissue amount J:129848
decreased muscle cell glucose uptake J:129848
decreased subcutaneous adipose tissue amount J:129848
decreased susceptibility to diet-induced obesity J:129848
impaired glucose tolerance J:129848
increased circulating glucose level J:129848
increased circulating insulin level J:129848
increased skeletal muscle triglyceride level J:129848
insulin resistance J:129848
Tg(Myh6-Ppara)402-2Dpk/0
involves: C57BL/6 * CBA/J 		abnormal cardiovascular system physiology J:110580
abnormal lipid level J:110580
abnormal myocardial fiber morphology J:110580
cardiac hypertrophy J:110580
cardiomyopathy J:110580
decreased heart ventricle muscle contractility J:110580
increased fatty acids level J:110580
Tg(Myh6-Ppara)404-3Dpk/0
involves: C57BL/6 * CBA/J 		abnormal cardiovascular system physiology J:110580
abnormal lipid level J:110580
abnormal myocardial fiber morphology J:110580
cardiac hypertrophy J:110580
cardiomyopathy J:81834, J:110580
decreased cardiac muscle cell glucose uptake J:110580
decreased heart ventricle muscle contractility J:110580
increased fatty acids level J:110580
Tg(Myh6-Ppara)404-4Dpk/0
involves: C57BL/6 * CBA/J 		abnormal lipid level J:110580
abnormal myocardial fiber morphology J:110580
cardiac hypertrophy J:110580
increased fatty acids level J:110580
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory