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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
MGI:104741
87 phenotypes from 7 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nfkbiatm1.1Kbp/Nfkbiatm1.1Kbp
involves: 129P2/OlaHsd * C57BL/6 		abnormal erythropoiesis J:97945
abnormal granulocyte morphology J:97945
increased bone marrow cell number J:97945
increased granulocyte number J:97945
postnatal growth retardation J:97945
postnatal lethality, complete penetrance J:97945
Nfkbiatm1.1Pjc/Nfkbiatm1.1Pjc
involves: C57BL/6 		abnormal circulating cytokine level J:163686
abnormal T cell activation J:163686
abnormal T cell number J:163686
autoimmune response J:163686
chronic inflammation J:163686
decreased CD4-positive, alpha-beta T cell number J:163686
decreased CD8-positive, alpha-beta T cell number J:163686
increased activated T cell number J:163686
increased anti-insulin autoantibody level J:163686
increased anti-nuclear antigen antibody level J:163686
increased circulating interleukin-1 alpha level J:163686
increased circulating interleukin-17 level J:163686
increased circulating tumor necrosis factor level J:163686
increased double-positive T cell number J:163686
increased memory T cell number J:163686
increased susceptibility to bacterial infection induced morbidity/mortality J:163686
increased T cell apoptosis J:163686
increased T cell proliferation J:163686
increased thymocyte number J:163686
premature death J:163686
Nfkbiatm1.1Smiy/Nfkbia+
B6.129-Nfkbiatm1.1Smiy 		decreased B cell number J:168977
decreased follicular B cell number J:168977
decreased marginal zone B cell number J:168977
decreased transitional stage T2 B cell number J:168977
increased pro-B cell number J:168977
small Peyer's patches J:168977
Nfkbiatm1.1Smiy/Nfkbiatm1.1Smiy
B6.129-Nfkbiatm1.1Smiy 		abnormal B cell differentiation J:168977
abnormal marginal zone B cell morphology J:168977
decreased B cell number J:168977
decreased B cell proliferation J:168977
decreased B-2 B cell number J:168977
decreased CD4-positive, alpha-beta memory T cell number J:168977
decreased follicular B cell number J:168977
decreased IgA level J:168977
decreased IgG1 level J:168977
decreased IgG2b level J:168977
decreased marginal zone B cell number J:168977
decreased mature B cell number J:168977
decreased Peyer's patch number J:168977
decreased regulatory T cell number J:168977
decreased transitional stage T2 B cell number J:168977
increased activation-induced B cell apoptosis J:168977
increased immature B cell number J:168977
increased pre-B cell number J:168977
increased pro-B cell number J:168977
small Peyer's patches J:168977
Nfkbiatm1Bal/Nfkbiatm1Bal
involves: 129S4/SvJae * C57BL/6J 		abnormal epidermis stratum basale morphology J:30058
abnormal granulocyte differentiation J:30058
abnormal skin condition J:30058
decreased body size J:30058
decreased double-positive T cell number J:30058
flaky skin J:30058
increased leukocyte cell number J:30058
postnatal lethality, complete penetrance J:30058
scaly skin J:30058
spleen atrophy J:30058
thymus atrophy J:30058
Nfkbiatm1Fey/Nfkbiatm1Fey
involves: 129S6/SvEvTac * C57BL/6 		abnormal B cell differentiation J:110817
abnormal cell differentiation J:110817
abnormal cell physiology J:110817
abnormal humoral immune response J:110817
absent spleen germinal center J:110817
anemia J:110817
decreased body size J:110817
decreased body weight J:110817
decreased double-negative T cell number J:110817
decreased T cell proliferation J:110817
decreased thymocyte number J:110817
dry skin J:110817
increased B cell proliferation J:110817
increased IgA level J:110817
increased IgE level J:110817
increased IgG level J:110817
increased single-positive T cell number J:110817
postnatal lethality, complete penetrance J:110817
reddish skin J:110817
scaly skin J:110817
small spleen J:110817
thymus atrophy J:110817
Nfkbiatm1Kbp/Nfkbiatm1Kbp
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 		normal hematopoietic system phenotype J:97945
Nfkbiatm1Stw/Nfkbiatm1Stw
involves: 129S1/Sv 		abnormal epidermis stratum corneum morphology J:32527
abnormal epidermis stratum granulosum morphology J:32527
abnormal erythropoiesis J:32527
abnormal keratinocyte morphology J:32527
abnormal macrophage physiology J:32527
abnormal myelopoiesis J:32527
abnormal tumor necrosis factor level J:32527
acanthosis J:32527
decreased body weight J:32527
dermatitis J:32527
dry skin J:32527
extramedullary hematopoiesis J:32527
flaky skin J:32527
hyperkeratosis J:32527
increased macrophage cell number J:32527
increased monocyte cell number J:32527
postnatal growth retardation J:32527
postnatal lethality, complete penetrance J:32527
spontaneous skin ulceration J:32527
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory