Nfasc Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nfasc
neurofascin
MGI:104753

25 phenotypes from 8 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nfasc^tm1.1Brp/Nfasc^tm1.1Brp B6.129P2-Nfasc^tm1.1Brp	abnormal sciatic nerve morphology	J:107591
	decreased nerve conduction velocity	J:107591
	postnatal lethality, complete penetrance	J:107591
Nfasc^tm1.1Brp/Nfasc^tm1.1Brp involves: 129P2/OlaHsd * C57BL/6	abnormal axon morphology	J:139185
	abnormal oligodendrocyte physiology	J:139185
Nfasc^tm1.1Brp/Nfasc^tm1.1Brp involves: 129P2/OlaHsd * ICR	abnormal axon morphology	J:166099
	paralysis	J:166099
	postnatal lethality, complete penetrance	J:166099
Nfasc^tm1.1Brp/Nfasc^tm1.1Brp Tg(Nefl-Nfasc)1Brp/0 involves: 129P2/OlaHsd * C57BL/6	abnormal axon morphology	J:139185
	abnormal oligodendrocyte physiology	J:139185
	normal nervous system phenotype	J:139185
	postnatal lethality, complete penetrance	J:139185
Nfasc^tm1.1Brp/Nfasc^tm1.1Brp Tg(Plp1-Nfasc)2Brp/0 involves: 129P2/OlaHsd * C57BL/6	abnormal axon morphology	J:139185
	normal nervous system phenotype	J:139185
Nfasc^tm1.1Brp/Nfasc^tm1.1Brp Tg(Plp1-Nfasc)1Brp/0 B6.Cg-Nfasc^tm1.1Brp Tg(Plp1-Nfasc)1Brp	abnormal sciatic nerve morphology	J:107591
Nfasc^tm1.1Brp/Nfasc^tm1.1Brp Tg(Plp1-Nfasc)1Brp/0 involves: 129P2/OlaHsd C57BL/6	normal nervous system phenotype	J:139185
Nfasc^tm1.1Brp/Nfasc^tm1.2Brp Tg(Thy1-cre/ERT2)#Brp/0 involves: 129P2/OlaHsd * C57BL/6	abnormal action potential	J:174740
	abnormal axon initial segment morphology	J:174740
	abnormal gait	J:174740
	abnormal synapse morphology	J:174740
	impaired ability to fire action potentials	J:174740
	impaired balance	J:174740
	impaired coordination	J:174740
	normal nervous system phenotype	J:174740
Nfasc^{tm1a(EUCOMM)Hmgu}/Nfasc⁺ C57BL/6N-Nfasc^{tm1a(EUCOMM)Hmgu}/Ics	increased circulating triglyceride level	J:165965
Nfasc^tm1Bhat/Nfasc^tm1Bhat Cnp^tm1(cre)Kan/? involves: 129S1/Sv * 129X1/SvJ	abnormal axon morphology	J:145846
	abnormal limb posture	J:145846
	abnormal motor capabilities/coordination/movement	J:145846
	abnormal motor coordination/balance	J:145846
	abnormal Purkinje cell axon morphology	J:145846
	decreased locomotor activity	J:145846
	decreased nerve conduction velocity	J:145846
	impaired balance	J:145846
	impaired coordination	J:145846
	postnatal growth retardation	J:145846
	postnatal lethality, complete penetrance	J:145846
	weight loss	J:145846
Nfasc^tm1Bhat/Nfasc^tm1Bhat Tg(Mpz-cre)26Mes/? involves: FVB/N	abnormal motor capabilities/coordination/movement	J:145846
	decreased nerve conduction velocity	J:145846
Nfasc^tm1Bhat/Nfasc^tm1Bhat Tg(Plp1-cre/ERT)3Pop/? involves: C57BL/6 * DBA/2	abnormal axon morphology	J:145846
	decreased nerve conduction velocity	J:145846
Nfasc^tm2Bhat/Nfasc^tm2Bhat Cnp^tm1(cre)Kan/Cnp⁺ involves: 129S1/Sv * 129X1/SvJ	abnormal paranodal axoglial junction morphology	J:159621
	abnormal paranode morphology	J:159621
	ataxia	J:159621
	impaired coordination	J:159621
	weight loss	J:159621
Nfasc^tm2Bhat/Nfasc^tm2Bhat Tmem163^{Tg(ACTB-cre)2Mrt}/0 involves: FVB/N	abnormal paranode morphology	J:159621

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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