Sik1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sik1
salt inducible kinase 1
MGI:104754

21 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Myf5^tm3(cre)Sor/Myf5⁺ Sik1^tm1.1Berd/Sik1^tm1.1Berd involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * SJL	abnormal gluconeogenesis	J:236223
	abnormal glucose homeostasis	J:236223
	decreased circulating insulin level	J:236223
	improved glucose tolerance	J:236223
	increased insulin sensitivity	J:236223
	increased skeletal muscle cell glucose uptake	J:236223
	normal muscle phenotype	J:236223
Sik1^{tm1.1(KOMP)Vlcg}/Sik1^{tm1.1(KOMP)Vlcg} C57BL/6N-Sik1^{tm1.1(KOMP)Vlcg}/Ucd	decreased circulating cholesterol level	J:211773
	decreased circulating serum albumin level	J:211773
	decreased circulating total protein level	J:211773
	decreased total body fat amount	J:211773
	increased bone mineral content	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased heart weight	J:211773
	increased kidney weight	J:211773
	increased lean body mass	J:211773
Sik1^tm1.1Berd/Sik1^tm1.1Berd involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL	decreased body weight	J:236223
	normal homeostasis/metabolism phenotype	J:236223
Sik1^tm1.1Berd/Sik1^tm1.1Berd Tg(Adipoq-cre)1Evdr/0 involves: 129S7/SvEvBrd * C57BL/6J * FVB/NJ * SJL	normal homeostasis/metabolism phenotype	J:236223
Sik1^tm1.2Berd/Sik1^tm1.2Berd involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL	abnormal glucose homeostasis	J:236223
	decreased body weight	J:236223
	decreased circulating glucose level	J:236223
	normal homeostasis/metabolism phenotype	J:236223
	increased circulating insulin level	J:236223
	increased insulin sensitivity	J:236223
	preweaning lethality, incomplete penetrance	J:236223

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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