Cdk2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cdk2
cyclin dependent kinase 2
MGI:104772

34 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cdk2^tm1.1Jro/Cdk2⁺ involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6	azoospermia	J:183801
	reduced male fertility	J:183801
	normal reproductive system phenotype	J:183801
	testicular atrophy	J:183801
Cdk2^tm1.1Jro/Cdk2^tm1.1Jro involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6	normal cellular phenotype	J:183801
	decreased body weight	J:183801
	prenatal lethality, incomplete penetrance	J:183801
Cdk2^tm1Kald/Cdk2^tm1Kald involves: 129S1/Sv	abnormal male meiosis	J:141249
	decreased hepatocyte proliferation	J:141249
	infertility	J:141249
Cdk2^tm1Kald/Cdk2^tm1Kald involves: 129S1/Sv * C57BL/6	abnormal cell cycle	J:86203
	abnormal male meiosis	J:86203
	abnormal oogenesis	J:86203
	abnormal ovary morphology	J:86203
	abnormal spermatogenesis	J:86203
	absent oocytes	J:86203
	absent primordial ovarian follicles	J:86203
	azoospermia	J:86203
	decreased body size	J:86203
	female infertility	J:86203
	male infertility	J:86203
	ovary atrophy	J:86203
	preweaning lethality, incomplete penetrance	J:86203
	small seminiferous tubules	J:86203
	small testis	J:86203
	uterus atrophy	J:86203
Cdk2^tm1Sgo/Cdk2^tm1Sgo involves: 129/Sv * CD-1	abnormal female reproductive system morphology	J:85230
	abnormal fertility/fecundity	J:85230
	abnormal gametogenesis	J:85230
	abnormal male reproductive system morphology	J:85230
	abnormal meiosis	J:85230
	abnormal oocyte morphology	J:85230
	abnormal seminiferous tubule morphology	J:85230
	abnormal spermiogenesis	J:85230
	absent corpus luteum	J:85230
	absent ovarian follicles	J:85230
	infertility	J:85230
	ovary atrophy	J:85230
	testicular atrophy	J:85230

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 06/12/2024 MGI 6.13