Cdk2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cdk2
cyclin dependent kinase 2
MGI:104772

58 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cdk1^{tm1(Cdk2)Kald}/Cdk1⁺ involves: 129 * C57BL/6	no abnormal phenotype detected	J:141249
Cdk1^{tm1(Cdk2)Kald}/Cdk1⁺ Cdk2^tm1Kald/Cdk2^tm1Kald involves: 129S1/Sv * C57BL/6	abnormal female reproductive system morphology	J:141249
	abnormal male meiosis	J:141249
	abnormal male reproductive system morphology	J:141249
	abnormal spermatid morphology	J:141249
	abnormal spermatocyte morphology	J:141249
	abnormal spermatogenesis	J:141249
	absent oocytes	J:141249
	absent ovarian follicles	J:141249
	female infertility	J:141249
	increased male germ cell apoptosis	J:141249
	infertility	J:141249
	male infertility	J:141249
	small ovary	J:141249
	small seminiferous tubules	J:141249
	small testis	J:141249
Cdk1^{tm1(Cdk2)Kald}/Cdk1^{tm1(Cdk2)Kald} involves: 129 * C57BL/6	embryonic lethality before implantation, complete penetrance	J:141249
Cdk2^tm1Kald/Cdk2^tm1Kald Cdk4^tm1Kiyo/Cdk4^tm1Kiyo involves: 129S1/Sv * C57BL/6	abnormal cardiac output	J:108720
	abnormal cell cycle	J:108720
	abnormal erythrocyte morphology	J:108720
	abnormal eye morphology	J:108720
	abnormal fetal cardiomyocyte proliferation	J:108720
	abnormal heart valve morphology	J:108720
	abnormal hematopoietic stem cell morphology	J:108720
	abnormal liver morphology	J:108720
	decreased cell proliferation	J:108720
	decreased embryo size	J:108720
	edema	J:108720
	hemorrhage	J:108720
	increased heart atrium size	J:108720
	lethality throughout fetal growth and development, incomplete penetrance	J:108720
	myocardial fiber disarray	J:108720
	pallor	J:108720
	small heart	J:108720
	thin ventricular wall	J:108720
	ventricular septal defect	J:108720
Cdk2^tm1Kald/Cdk2^tm1Kald Cdk4^tm1Kiyo/Cdk4^tm1Kiyo Cdkn1b^tm1Ako/Cdkn1b^tm1Ako involves: 129S1/Sv * C57BL/6	decreased cell proliferation	J:108720
	lethality throughout fetal growth and development, complete penetrance	J:108720
Cdk2^tm1Sgo/Cdk2⁺ Cdk4^tm2.1Bbd/Cdk4⁺ involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	abnormal embryo development	J:125217
Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk4^tm1Bbd/Cdk4^tm1Bbd Cdk6^tm1Bbd/Cdk6^tm1Bbd involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal common myeloid progenitor cell morphology	J:124678
	decreased cell proliferation	J:124678
	decreased embryo size	J:124678
	decreased myocardial fiber number	J:124678
	embryonic lethality during organogenesis, incomplete penetrance	J:124678
	lethality throughout fetal growth and development, complete penetrance	J:124678
	liver hypoplasia	J:124678
	thin ventricular wall	J:124678
Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk4^tm2.1Bbd/Cdk4^tm2.1Bbd involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	abnormal cell cycle	J:125217
	abnormal definitive hematopoiesis	J:125217
	abnormal fetal cardiomyocyte proliferation	J:125217
	abnormal liver physiology	J:125217
	congestive heart failure	J:125217
	decreased body weight	J:125217
	decreased erythrocyte cell number	J:125217
	decreased fibroblast proliferation	J:125217
	increased myocardial fiber size	J:125217
	liver hypoplasia	J:125217
	neonatal lethality, complete penetrance	J:125217
	thin ventricular wall	J:125217
Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk6^tm1Bbd/Cdk6^tm1Bbd involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal gametogenesis	J:92529
	abnormal oogenesis	J:92529
	abnormal spermatogenesis	J:92529
	infertility	J:92529
Cdk2^tm1Sgo/Cdk2^tm1Sgo Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129S1/Sv * 129X1/SvJ	decreased tumor incidence	J:161780
	premature death	J:161780
Cdk2^tm2Sgo/Cdk2^tm2Sgo Cdk4^tm2.1Bbd/Cdk4^tm2.1Bbd Polr2a^{tm1(cre/ERT2)Bbd}/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	decreased body size	J:125217
	normal hematopoietic system phenotype	J:125217
	increased susceptibility to autoimmune diabetes	J:125217
	normal liver/biliary system phenotype	J:125217
Cdk2^tm2Sgo/Cdk2^tm2Sgo Kras^tm1Bbd/Kras^tm2Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129S1/Sv * 129X1/SvJ	decreased tumor incidence	J:161780
	premature death	J:161780

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24