Cdk2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cdk2
cyclin dependent kinase 2
MGI:104772

58 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cdk1^{tm1(Cdk2)Kald}/Cdk1⁺ involves: 129 * C57BL/6	no abnormal phenotype detected	J:141249
Cdk1^{tm1(Cdk2)Kald}/Cdk1⁺ Cdk2^tm1Kald/Cdk2^tm1Kald involves: 129S1/Sv * C57BL/6	abnormal female reproductive system morphology	J:141249
	abnormal male meiosis	J:141249
	abnormal male reproductive system morphology	J:141249
	abnormal spermatid morphology	J:141249
	abnormal spermatocyte morphology	J:141249
	abnormal spermatogenesis	J:141249
	absent oocytes	J:141249
	absent ovarian follicles	J:141249
	female infertility	J:141249
	increased male germ cell apoptosis	J:141249
	infertility	J:141249
	male infertility	J:141249
	small ovary	J:141249
	small seminiferous tubules	J:141249
	small testis	J:141249
Cdk1^{tm1(Cdk2)Kald}/Cdk1^{tm1(Cdk2)Kald} involves: 129 * C57BL/6	embryonic lethality before implantation, complete penetrance	J:141249
Cdk2^tm1Kald/Cdk2^tm1Kald Cdk4^tm1Kiyo/Cdk4^tm1Kiyo involves: 129S1/Sv * C57BL/6	abnormal cardiac output	J:108720
	abnormal cell cycle	J:108720
	abnormal erythrocyte morphology	J:108720
	abnormal eye morphology	J:108720
	abnormal fetal cardiomyocyte proliferation	J:108720
	abnormal heart valve morphology	J:108720
	abnormal hematopoietic stem cell morphology	J:108720
	abnormal liver morphology	J:108720
	decreased cell proliferation	J:108720
	decreased embryo size	J:108720
	edema	J:108720
	hemorrhage	J:108720
	increased heart atrium size	J:108720
	lethality throughout fetal growth and development, incomplete penetrance	J:108720
	myocardial fiber disarray	J:108720
	pallor	J:108720
	small heart	J:108720
	thin ventricular wall	J:108720
	ventricular septal defect	J:108720
Cdk2^tm1Kald/Cdk2^tm1Kald Cdk4^tm1Kiyo/Cdk4^tm1Kiyo Cdkn1b^tm1Ako/Cdkn1b^tm1Ako involves: 129S1/Sv * C57BL/6	decreased cell proliferation	J:108720
	lethality throughout fetal growth and development, complete penetrance	J:108720
Cdk2^tm1Sgo/Cdk2⁺ Cdk4^tm2.1Bbd/Cdk4⁺ involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	abnormal embryo development	J:125217
Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk4^tm1Bbd/Cdk4^tm1Bbd Cdk6^tm1Bbd/Cdk6^tm1Bbd involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal common myeloid progenitor cell morphology	J:124678
	decreased cell proliferation	J:124678
	decreased embryo size	J:124678
	decreased myocardial fiber number	J:124678
	embryonic lethality during organogenesis, incomplete penetrance	J:124678
	lethality throughout fetal growth and development, complete penetrance	J:124678
	liver hypoplasia	J:124678
	thin ventricular wall	J:124678
Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk4^tm2.1Bbd/Cdk4^tm2.1Bbd involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	abnormal cell cycle	J:125217
	abnormal definitive hematopoiesis	J:125217
	abnormal fetal cardiomyocyte proliferation	J:125217
	abnormal liver physiology	J:125217
	congestive heart failure	J:125217
	decreased body weight	J:125217
	decreased erythrocyte cell number	J:125217
	decreased fibroblast proliferation	J:125217
	increased myocardial fiber size	J:125217
	liver hypoplasia	J:125217
	neonatal lethality, complete penetrance	J:125217
	thin ventricular wall	J:125217
Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk6^tm1Bbd/Cdk6^tm1Bbd involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal gametogenesis	J:92529
	abnormal oogenesis	J:92529
	abnormal spermatogenesis	J:92529
	infertility	J:92529
Cdk2^tm1Sgo/Cdk2^tm1Sgo Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129S1/Sv * 129X1/SvJ	decreased tumor incidence	J:161780
	premature death	J:161780
Cdk2^tm2Sgo/Cdk2^tm2Sgo Cdk4^tm2.1Bbd/Cdk4^tm2.1Bbd Polr2a^{tm1(cre/ERT2)Bbd}/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	decreased body size	J:125217
	normal hematopoietic system phenotype	J:125217
	increased susceptibility to autoimmune diabetes	J:125217
	normal liver/biliary system phenotype	J:125217
Cdk2^tm2Sgo/Cdk2^tm2Sgo Kras^tm1Bbd/Kras^tm2Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129S1/Sv * 129X1/SvJ	decreased tumor incidence	J:161780
	premature death	J:161780

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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