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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Adra1b
adrenergic receptor, alpha 1b
MGI:104774
44 phenotypes from 1 allele in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Adra1btm1Cta/Adra1btm1Cta
involves: 129 * C57BL/6J 		abnormal male germ cell apoptosis J:125763
abnormal seminiferous tubule morphology J:125763
abnormal Sertoli cell morphology J:125763
arrest of spermatogenesis J:125763
decreased circulating testosterone level J:125763
decreased litter size J:125763
decreased male germ cell number J:125763
decreased testes secretion J:125763
decreased testis weight J:125763
increased circulating luteinizing hormone level J:125763
male infertility J:125763
reduced male fertility J:125763
normal reproductive system phenotype J:125763
small seminal vesicle J:125763
small seminiferous tubules J:125763
small testis J:125763
Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd 		abnormal baroreceptor physiology J:103581
abnormal heart left ventricle morphology J:103581
abnormal systemic arterial blood pressure J:43591
decreased cardiac muscle contractility J:43591, J:103581
decreased exploration in new environment J:102553
decreased heart rate J:103581
decreased systemic arterial blood pressure J:103581
decreased systemic arterial systolic blood pressure J:103581
decreased vasoconstriction J:103581
impaired passive avoidance behavior J:102553
Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J 		abnormal glucose homeostasis J:87718
abnormal learning/memory/conditioning J:68177
abnormal pancreatic beta cell physiology J:87718
abnormal response to novel object J:68177
abnormal spatial learning J:68177
decreased circulating free fatty acids level J:87718
decreased skeletal muscle glycogen level J:87718
hyperglycemia J:87718
impaired behavioral response to addictive substance J:76004
impaired conditioned place preference behavior J:76004
impaired glucose tolerance J:87718
increased circulating insulin level J:87718
increased circulating leptin level J:87718
increased exploration in new environment J:68177
increased liver glycogen level J:87718
increased percent body fat/body weight J:87718
increased susceptibility to diet-induced obesity J:87718
insulin resistance J:87718
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory