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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prkdc
protein kinase, DNA activated, catalytic polypeptide
MGI:104779
158 phenotypes from 30 alleles in 42 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Prkdcberty/Prkdcberty
C57BL/6JAnu-Prkdcberty 		absent B cells J:104190
absent T cells J:104190
Prkdcdxnph/Prkdcdxnph
129X1/SvJ 		abnormal kidney morphology J:96632
glomerulosclerosis J:96632
increased physiological sensitivity to xenobiotic J:96632
increased urine protein level J:96632
Prkdcdxnph/Prkdcdxnph
BALB/c 		increased cellular sensitivity to gamma-irradiation J:68487
Prkdcdxnph/Prkdcdxnph
BALB/cJ 		abnormal kidney morphology J:96632
glomerulosclerosis J:96632
increased physiological sensitivity to xenobiotic J:96632
increased urine protein level J:96632
Prkdcdxnph/Prkdcdxnph
involves: BALB/cJ * 129X1/SvJ 		glomerulosclerosis J:96632
increased urine protein level J:96632
Prkdcem2(IMPC)Ics/Prkdcem2(IMPC)Ics
C57BL/6N-Prkdcem2(IMPC)Ics/Ics 		decreased leukocyte cell number J:211773
decreased lymphocyte cell number J:211773
decreased mean corpuscular hemoglobin concentration J:211773
increased circulating phosphate level J:211773
increased eosinophil cell number J:211773
increased monocyte cell number J:211773
increased neutrophil cell number J:211773
Prkdchanky/Prkdchanky
either: C57BL/6JAnu or (involves: C57BL/6JAnu * CBA/CaJ) 		cecum inflammation J:104190
colitis J:104190
decreased lymphocyte cell number J:104190
diarrhea J:104190
enlarged mesenteric lymph nodes J:104190
increased bone marrow cell number J:104190
increased plasma cell number J:104190
interstitial pneumonia J:104190
liver inflammation J:104190
lymph node hyperplasia J:104190
myeloid hyperplasia J:104190
Prkdcm1Anu/Prkdcm1Anu
C57BL/6JAnu-Prkdcm1Anu 		abnormal lymphocyte morphology J:104190
Prkdcm1Btlr/Prkdcm1Btlr
C57BL/6J-Prkdcm1Btlr 		abnormal immune system physiology J:178522
Prkdcm1Btlr/Prkdcm1Btlr
involves: C57BL/6J 		abnormal class switch recombination J:185495
decreased B cell number J:185495
decreased IgG level J:185495
decreased IgM level J:185495
Prkdcm2Btlr/Prkdcm2Btlr
C57BL/6J-Prkdcm2Btlr 		abnormal B cell physiology J:204502
decreased B cell number J:204502
decreased CD4-positive, alpha-beta T cell number J:204502
decreased CD8-positive, alpha-beta T cell number J:204502
decreased IgG level J:204502
decreased IgM level J:204502
Prkdcm3Btlr/Prkdcm3Btlr
C57BL/6J-Prkdcm3Btlr 		decreased IgG level J:224665
impaired humoral immune response J:224665
Prkdcm4Btlr/Prkdcm4Btlr
C57BL/6J-Prkdcm4Btlr 		decreased B cell number J:255217
increased B-1b cell number J:255217
increased neutrophil cell number J:255217
Prkdcm5Btlr/Prkdcm5Btlr
C57BL/6J-Prkdcm5Btlr 		increased alpha-beta T cell number J:255220
increased CD4-positive, alpha-beta T cell number J:255220
Prkdcm6Btlr/Prkdcm6Btlr
C57BL/6J-Prkdcm6Btlr 		decreased CD8-positive, naive alpha-beta T cell number J:255221
increased alpha-beta T cell number J:255221
increased CD4-positive, alpha-beta T cell number J:255221
increased CD8-positive, alpha-beta T cell number J:255221
Prkdcm7Btlr/Prkdcm7Btlr
C57BL/6J-Prkdcm7Btlr 		abnormal humoral immune response J:255223
decreased IgG level J:255223
increased effector memory CD4-positive, alpha-beta T cell number J:255223
PrkdcM8Btlr/Prkdc+
C57BL/6J-PrkdcM8Btlr 		decreased CD8-positive, alpha-beta T cell number J:255224
PrkdcM8Btlr/PrkdcM8Btlr
C57BL/6J-PrkdcM8Btlr 		decreased CD8-positive, alpha-beta T cell number J:255224
increased CD4-positive, alpha-beta T cell number J:255224
increased plasmacytoid dendritic cell number J:255224
PrkdcM9Btlr/Prkdc+
C57BL/6J-PrkdcM9Btlr 		decreased B-1a cell number J:255268
decreased effector memory CD4-positive, alpha-beta T cell number J:255268
increased B cell number J:255268
increased B-1b cell number J:255268
PrkdcM9Btlr/PrkdcM9Btlr
C57BL/6J-PrkdcM9Btlr 		decreased B-1a cell number J:255268
decreased effector memory CD4-positive, alpha-beta T cell number J:255268
increased B cell number J:255268
increased B-1b cell number J:255268
PrkdcM10Btlr/Prkdc+
C57BL/6J-PrkdcM10Btlr 		decreased CD8-positive, alpha-beta T cell number J:255269
PrkdcM10Btlr/PrkdcM10Btlr
C57BL/6J-PrkdcM10Btlr 		decreased CD8-positive, alpha-beta T cell number J:255269
PrkdcM11Btlr/Prkdc+
C57BL/6J-PrkdcM11Btlr 		enhanced humoral immune response J:255270
increased IgM level J:255270
PrkdcM11Btlr/PrkdcM11Btlr
C57BL/6J-PrkdcM11Btlr 		enhanced humoral immune response J:255270
increased IgM level J:255270
Prkdcm12Btlr/Prkdcm12Btlr
C57BL/6J-Prkdcm12Btlr 		decreased B cell number J:264708
decreased B-1 B cell number J:264708
decreased CD4-positive, alpha-beta T cell number J:264708
decreased CD8-positive, alpha-beta T cell number J:264708
decreased CD8-positive, naive alpha-beta T cell number J:264708
decreased NK T cell number J:264708
decreased single-positive T cell number J:264708
decreased T cell number J:264708
increased central memory CD4-positive, alpha-beta T cell number J:264708
increased central memory CD8 positive, alpha-beta T cell number J:264708
increased effector memory CD4-positive, alpha-beta T cell number J:264708
increased NK cell number J:264708
Prkdcm13Btlr/Prkdcm13Btlr
C57BL/6J-Prkdcm13Btlr 		increased effector memory CD4-positive, alpha-beta T cell number J:272441
Prkdcm14Btlr/Prkdcm14Btlr
C57BL/6J-Prkdcm14Btlr 		abnormal CD4-positive T cell differentiation J:272442
increased body weight J:272442
PrkdcM15Btlr/PrkdcM15Btlr
C57BL/6J-PrkdcM15Btlr 		decreased B-1 B cell number J:272445
PrkdcM16Btlr/PrkdcM16Btlr
C57BL/6J-PrkdcM16Btlr 		abnormal CD8-positive, alpha-beta T cell differentiation J:272520
Prkdcm17Btlr/Prkdcm17Btlr
C57BL/6J-Prkdcm17Btlr 		increased plasmacytoid dendritic cell number J:272521
Prkdcm18Btlr/Prkdcm18Btlr
C57BL/6J-Prkdcm18Btlr 		abnormal B cell differentiation J:274730
abnormal CD4-positive T cell differentiation J:274730
abnormal CD8-positive, alpha-beta T cell differentiation J:274730
abnormal T cell differentiation J:274730
decreased alpha-beta T cell number J:274730
decreased B cell number J:274730
decreased B-1 B cell number J:274730
decreased CD4-positive, alpha-beta T cell number J:274730
decreased CD8-positive, alpha-beta T cell number J:274730
decreased CD8-positive, naive alpha-beta T cell number J:274730
increased CD4-positive, alpha-beta T cell number J:274730
increased CD8-positive, alpha-beta T cell number J:274730
increased central memory CD4-positive, alpha-beta T cell number J:274730
increased central memory CD8 positive, alpha-beta T cell number J:274730
increased effector memory CD4-positive, alpha-beta T cell number J:274730
increased effector memory CD8-positive, alpha-beta T cell number J:274730
increased T cell number J:274730
Prkdcm19Btlr/Prkdcm19Btlr
C57BL/6J-Prkdcm19Btlr 		abnormal B cell differentiation J:274763
abnormal CD4-positive T cell differentiation J:274763
abnormal CD8-positive, alpha-beta T cell differentiation J:274763
abnormal T cell differentiation J:274763
decreased B cell number J:274763
decreased B-1 B cell number J:274763
decreased CD4-positive, alpha-beta T cell number J:274763
decreased CD8-positive, alpha-beta T cell number J:274763
decreased CD8-positive, naive alpha-beta T cell number J:274763
decreased T cell number J:274763
increased central memory CD4-positive, alpha-beta T cell number J:274763
increased central memory CD8 positive, alpha-beta T cell number J:274763
increased effector memory CD4-positive, alpha-beta T cell number J:274763
increased effector memory CD8-positive, alpha-beta T cell number J:274763
increased NK cell number J:274763
Prkdcscid/Prkdcscid
B6.Cg-Prkdcscid/Sz 		abnormal complement pathway J:22026, J:34814
abnormal level of surface class II molecules J:34814
abnormal lymph node B cell domain morphology J:34814
abnormal NK cell physiology J:34814
abnormal Peyer's patch morphology J:34814
abnormal spleen white pulp morphology J:34814
abnormal thymus morphology J:34814
decreased B cell number J:34814
decreased CD4-positive, alpha-beta T cell number J:34814
decreased CD8-positive, alpha-beta T cell number J:34814
decreased immunoglobulin level J:34814
decreased lymphocyte cell number J:34814
decreased pre-B cell number J:34814
decreased T cell number J:34814
increased eosinophil cell number J:34814
increased granulocyte number J:34814
increased macrophage cell number J:34814
increased monocyte cell number J:34814
increased neutrophil cell number J:34814
increased NK cell number J:34814
small Peyer's patches J:34814
small thymus J:34814
spleen hypoplasia J:34814
stomach inflammation J:120556
thymus cyst J:34814
Prkdcscid/Prkdcscid
C.BKa-Prkdcscid 		abnormal humoral immune response J:6958
abnormal response to transplant J:22026
abnormal spleen white pulp morphology J:6958
abnormal thymus morphology J:6958
absent B cells J:6958
absent Peyer's patches J:6958
absent pre-B cells J:6958
absent thymus cortex J:6958
decreased B cell proliferation J:6958
decreased IgG level J:6958
decreased immunoglobulin level J:6958, J:22026
decreased leukocyte cell number J:6958
decreased T cell proliferation J:6958
normal hematopoietic system phenotype J:22026
normal immune system phenotype J:22026
increased length of allograft survival J:6958, J:22026
increased T cell derived lymphoma incidence J:6958
lymph node hypoplasia J:6958
lymphoid hypoplasia J:6958
premature death J:6958
salivary gland inflammation J:21965
small lymphoid organs J:6958
small thymus J:6958
thymus cyst J:6958
Prkdcscid/Prkdcscid
involves: BALB/c * C57BL/6 * C57BL/Ka 		abnormal NK cell physiology J:115033
Prkdcscid/Prkdcscid
involves: BALB/c * C57BL/10ScSn * C57BL/Ka 		normal muscle phenotype J:125527
Prkdcscid/Prkdcscid
involves: BALB/c * C57BL/Ka 		abnormal intestinal epithelium morphology J:126867
Prkdcscid/Prkdcscid
NOD.Cg-Prkdcscid 		abnormal lymph node morphology J:22026, J:109833
abnormal response to transplant J:22026, J:109833
abnormal spleen white pulp morphology J:22026, J:109833
abnormal thymus corticomedullary boundary morphology J:22026
abnormal thymus lobule morphology J:22026
decreased B cell number J:22026
decreased bone marrow cell number J:22026
decreased CD4-positive, alpha-beta T cell number J:22026, J:109833
decreased CD8-positive, alpha-beta T cell number J:22026, J:109833
decreased erythrocyte cell number J:22026
decreased immunoglobulin level J:22026
decreased level of surface class I molecules J:22026
decreased lymphocyte cell number J:22026
decreased mature B cell number J:109833
decreased NK cell number J:22026
decreased pre-B cell number J:22026
decreased T cell number J:22026
normal homeostasis/metabolism phenotype J:22026
impaired complement classical pathway J:22026
impaired natural killer cell mediated cytotoxicity J:22026
increased cellular sensitivity to X-ray irradiation J:109833
increased granulocyte number J:22026
increased length of allograft survival J:22026
increased macrophage cell number J:22026
increased mean corpuscular volume J:22026
increased T cell derived lymphoma incidence J:22026, J:109833
premature death J:22026, J:109833
spleen hypoplasia J:22026, J:109833
thymus cyst J:22026
Prkdcscid/Prkdcscid
NOD.Cg-Prkdcscid/J 		abnormal response to transplant J:91764
increased circulating glucose level J:91764
PrkdcTg(INS-PDE2)5-1Lmb/?
involves: FVB/N 		abnormal thymus morphology J:108405
increased cellular sensitivity to gamma-irradiation J:108405
increased mortality induced by gamma-irradiation J:108405
Prkdctm1.1Bpcc/Prkdc+
involves: 129 * C57BL/6 		hyperpigmentation J:171351
Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
involves: 129 * C57BL/6 		abnormal DNA repair J:171351
abnormal hematopoietic stem cell physiology J:171351
abnormal immunoglobulin V(D)J recombination J:171351
arrested B cell differentiation J:171351
decreased bone marrow cell number J:171351
decreased CD4-positive, alpha-beta T cell number J:171351
decreased CD8-positive, alpha-beta T cell number J:171351
decreased double-negative T cell number J:171351
decreased double-positive T cell number J:171351
decreased erythrocyte cell number J:171351
decreased gamma-delta T cell number J:171351
decreased granulocyte number J:171351
decreased hematopoietic stem cell number J:171351
decreased leukocyte cell number J:171351
decreased lymphocyte cell number J:171351
decreased macrophage cell number J:171351
decreased mature B cell number J:171351
decreased T cell number J:171351
hyperpigmentation J:171351
increased cellular sensitivity to alkylating agents J:171351
increased cellular sensitivity to ionizing radiation J:171351
increased cellular sensitivity to ultraviolet irradiation J:171351
increased mortality induced by ionizing radiation J:171351
increased sensitivity to induced cell death J:171351
increased small intestinal crypt cell apoptosis J:171351
pallor J:171351
pancytopenia J:171351
postnatal lethality, incomplete penetrance J:171351
premature death J:171351
slow postnatal weight gain J:171351
small lymphoid organs J:171351
thrombocytopenia J:171351
Prkdctm1Fwa/Prkdctm1Fwa
involves: 129S6/SvEvTac 		decreased splenocyte number J:306598
normal nervous system phenotype J:110848
Prkdctm1Fwa/Prkdctm1Fwa
involves: 129S6/SvEvTac * C57BL/6 		abnormal T cell receptor beta chain V(D)J recombination J:50221
abnormal T cell receptor V(D)J recombination J:50221
absent pre-B cells J:50221
arrested B cell differentiation J:50221
arrested T cell differentiation J:50221
decreased double-positive T cell number J:50221
decreased thymocyte number J:50221
increased cellular sensitivity to ionizing radiation J:50221
Prkdctm1Gcl/Prkdctm1Gcl
involves: 129S1/Sv 		normal cellular phenotype J:126920
decreased thymocyte apoptosis J:126920
Prkdctm1Gcl/Prkdctm1Gcl
involves: 129S1/Sv * C57BL/6 		abnormal colon morphology J:53765
abnormal immunoglobulin heavy chain V(D)J recombination J:53765
abnormal large intestine crypts of Lieberkuhn morphology J:53765
abnormal lymph node morphology J:53765
abnormal spleen morphology J:53765
abnormal T cell receptor beta chain V(D)J recombination J:53765
abnormal T cell receptor delta chain V(D)J recombination J:53765
absent mature B cells J:53765
absent Peyer's patches J:53765
absent thymus corticomedullary boundary J:53765
arrested B cell differentiation J:53765
increased cellular sensitivity to gamma-irradiation J:53765
increased T cell derived lymphoma incidence J:53765
intestine polyps J:53765
preneoplasia J:53765
small lymph nodes J:53765
small Peyer's patches J:53765
small spleen J:53765
small thymus J:53765
thymus hypoplasia J:53765
Prkdctm1Get/Prkdctm1Get
involves: 129S4/SvJae * Black Swiss 		abnormal B cell differentiation J:50222
abnormal immunoglobulin heavy chain V(D)J recombination J:50222
abnormal immunoglobulin light chain V-J recombination J:50222
abnormal T cell differentiation J:50222
abnormal T cell number J:50222
abnormal T cell receptor alpha chain V-J recombination J:50222
abnormal T cell receptor beta chain V(D)J recombination J:50222
abnormal T cell receptor delta chain V(D)J recombination J:50222
abnormal thymus corticomedullary boundary morphology J:50222
arrested B cell differentiation J:50222
arrested T cell differentiation J:50222
decreased IgM level J:50222
decreased single-positive T cell number J:50222
decreased spleen white pulp amount J:50222
increased cellular sensitivity to gamma-irradiation J:50222
increased double-negative T cell number J:50222
increased double-positive T cell number J:50222
increased NK cell number J:50222
small lymph nodes J:50222
spleen hypoplasia J:50222
thymus hypoplasia J:50222
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory