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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prkdc
protein kinase, DNA activated, catalytic polypeptide
MGI:104779
132 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
ApcMin/Apc+
Pla2g2aMom1-r/?
Prkdcdxnph/Prkdcdxnph
involves: BALB/cByJ * C57BL/6 		increased incidence of tumors by ionizing radiation induction J:83497
B2mtm1Unc/B2mtm1Unc
Emv30b/Emv30b
Prkdcscid/Prkdcscid
Tg(B2M)55Hpl/?
Mcph1Tg(HLA-A2.1)1Enge/?
NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs 		decreased susceptibility to autoimmune diabetes J:109851
B2mtm1Unc/B2mtm1Unc
Prkdcscid/Prkdcscid
NOD.Cg-B2mtm1Unc Prkdcscid 		abnormal NK cell physiology J:102141
abnormal response to transplant J:102141
absent lymphocyte J:102141
arrested B cell differentiation J:102141
arrested T cell differentiation J:102141
decreased level of surface class I molecules J:102141
increased liver iron level J:102141
increased macrophage cell number J:102141
increased T cell derived lymphoma incidence J:102141
premature death J:102141
Dmdmdx/Dmdmdx
Prkdcscid/Prkdcscid
involves: BALB/c * C57BL/10ScSn * C57BL/Ka 		abnormal vertebral column morphology J:125527
absent CD4-positive, alpha-beta T cells J:125527
absent CD8-positive, alpha-beta T cells J:125527
centrally nucleated skeletal muscle fibers J:125527
decreased B cell number J:125527
decreased transforming growth factor beta level J:125527
impaired exercise endurance J:125527
impaired skeletal muscle contractility J:125527
increased skeletal muscle fiber diameter J:125527
reduced fertility J:125527
skeletal muscle fiber degeneration J:125527
skeletal muscle fibrosis J:125527
Dxmod/Dxmod
Prkdcdxnph/Prkdcdxnph
involves: BALB/cJ * 129X1/SvJ 		dilated renal tubule J:96632
glomerulosclerosis J:96632
Emv30b/Emv30b
Prkdcscid/Prkdcscid
NOD.Cg-Emv30b Prkdcscid/Dvs 		increased T cell derived lymphoma incidence J:29951
Emv30b/Emv30b
Prkdcscid/Prkdcscid
Tg(IghH280)48Dvs/?
Tg(IgkH280)934Dvs/?
NOD.Cg-Emv30b Prkdcscid Tg(IghH280)48Dvs Tg(IgkH280)934Dvs/Dvs 		normal homeostasis/metabolism phenotype J:274578
Ightm2Cgn/Igh+
Igktm2Rsky/Igk+
Prkdcscid/Prkdcscid
involves: 129P2/OlaHsd * BALB/c * C57BL/Ka 		abnormal class switch recombination J:150435
Il2rgtm1Wjl/Il2rgtm1Wjl
Prkdcscid/Prkdcscid
NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz 		abnormal glucose homeostasis J:138005
abnormal immune system organ morphology J:109833
abnormal response to transplant J:109833
abnormal splenic cell ratio J:109833
abnormal thymus morphology J:109833
decreased CD4-positive, alpha-beta T cell number J:109833
decreased CD8-positive, alpha-beta T cell number J:109833
decreased immature B cell number J:109833
decreased immunoglobulin level J:109833
decreased incidence of tumors by ionizing radiation induction J:109833
decreased leukocyte cell number J:109833
decreased mature B cell number J:109833
decreased mean corpuscular volume J:109833
decreased NK cell number J:109833
decreased spleen B cell follicle number J:109833
hyperglycemia J:138005
increased cellular sensitivity to X-ray irradiation J:109833
lymph node hypoplasia J:109833
premature death J:109833
small lymph nodes J:109833
thymus cyst J:109833
Il2rgtm1Wjl/Y
Prkdcscid/Prkdcscid
NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz 		abnormal immune system organ morphology J:109833
abnormal response to transplant J:109833, J:140388
abnormal splenic cell ratio J:109833
abnormal thymus morphology J:109833
decreased CD4-positive, alpha-beta T cell number J:109833
decreased CD8-positive, alpha-beta T cell number J:109833
decreased immature B cell number J:109833
decreased immunoglobulin level J:109833
decreased leukocyte cell number J:109833
decreased mature B cell number J:109833
decreased mean corpuscular volume J:109833
decreased NK cell number J:109833
decreased spleen B cell follicle number J:109833
increased cellular sensitivity to X-ray irradiation J:109833
lymph node hypoplasia J:109833
premature death J:109833
small lymph nodes J:109833
Lystbg-J/Lystbg-J
Prkdcscid/Prkdcscid
B6.Cg-Lystbg-J Prkdcscid/Sz 		abnormal complement pathway J:34814
abnormal granulocyte morphology J:34814
abnormal level of surface class II molecules J:34814
abnormal lymph node morphology J:34814
abnormal neutrophil morphology J:34814
abnormal Peyer's patch morphology J:34814
abnormal spleen white pulp morphology J:34814
abnormal thymus morphology J:34814
decreased B cell number J:34814
decreased CD4-positive, alpha-beta T cell number J:34814
decreased CD8-positive, alpha-beta T cell number J:34814
decreased immunoglobulin level J:34814
decreased lymphocyte cell number J:34814
decreased pre-B cell number J:34814
decreased T cell number J:34814
impaired natural killer cell mediated cytotoxicity J:34814
increased eosinophil cell number J:34814
increased granulocyte number J:34814
increased macrophage cell number J:34814
increased monocyte cell number J:34814
increased neutrophil cell number J:34814
increased NK cell number J:34814
small Peyer's patches J:34814
small thymus J:34814
spleen hypoplasia J:34814
thymus cyst J:34814
Lystbg/Lystbg
Prkdcscid/Prkdcscid
Not Specified 		increased susceptibility to infection J:4752
Prkdcscid/Prkdc+
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * C57BL/6J 		increased thymoma incidence J:47667
premature death J:47667
Prkdcscid/Prkdc+
Tg(LPV-TAg1135)11Tvd/0
involves: C57BL/6J * DBA/2J 		increased thymoma incidence J:47667
premature death J:47667
Prkdcscid/Prkdcscid
Gnrh1hpg/Gnrh1hpg
STOCK Prkdcscid Gnrh1hpg/Bm 		abnormal circulating protein level J:138840
absent seminal vesicle J:138840
decreased circulating testosterone level J:138840
decreased kidney weight J:138840
decreased liver weight J:138840
decreased tumor incidence J:14443, J:138840
small salivary gland J:138840
Prkdcscid/Prkdcscid
Iduatm1Clk/Idua+
NOD.Cg-Prkdcscid Iduatm1Clk/J 		broad head J:139626
enophthalmos J:139626
rough coat J:139626
short snout J:139626
small ears J:139626
Prkdcscid/Prkdcscid
Iduatm1Clk/Iduatm1Clk
NOD.Cg-Prkdcscid Iduatm1Clk/J 		abnormal brain morphology J:139626
abnormal brainstem morphology J:139626
abnormal cerebellar cortex morphology J:139626
abnormal cerebellum morphology J:139626
abnormal hippocampus morphology J:139626
abnormal homeostasis J:139626
abnormal motor learning J:139626
abnormal striatum morphology J:139626
abnormal zygomatic bone morphology J:139626
broad head J:139626
enophthalmos J:139626
female infertility J:139626
impaired coordination J:139626
increased urine glycosaminoglycan level J:139626
pup cannibalization J:139626
rough coat J:139626
short snout J:139626
small ears J:139626
Prkdcscid/Prkdcscid
Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
NOD.Cg-Mcph1Tg(HLA-A2.1)1Enge Prkdcscid/Dvs 		abnormal splenocyte morphology J:91764
Prkdcscid/Prkdcscid
Rasa3scat/Rasa3scat
involves: BALB/c * BALB/cBy * C57BL 		abnormal hematopoietic system morphology/development J:186485
abnormal immune system morphology J:186485
Prkdcscid/Prkdcscid
Sst1C57BL/6J/Sst1C57BL/6J
involves: C3HeB/FeJ * C57BL/6J 		decreased susceptibility to bacterial infection J:93705
Prkdcscid/Prkdcscid
Tg(B2M)55Hpl/0
Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
NOD.Cg-Mcph1Tg(HLA-A2.1)1Enge Prkdcscid Tg(B2M)55Hpl/Sz 		abnormal response to transplant J:91764
increased circulating glucose level J:91764
Prkdcscid/Prkdcscid
Tg(CSF2)2Ygy/0
Tg(IL3)1Ygy/0
CB17.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy 		abnormal response to transplant J:94302
Prkdcscid/Prkdcscid
Tg(CSF2)2Ygy/0
Tg(IL3)1Ygy/0
Tg(KITLG)3Ygy/0
CB17.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy 		abnormal response to transplant J:94302, J:106416
Prkdcscid/Prkdcscid
Tg(CSF2)2Ygy/0
Tg(IL3)1Ygy/0
Tg(KITLG)3Ygy/0
NOD.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy 		abnormal response to transplant J:107052
decreased susceptibility to graft versus host disease J:107052
Prkdcscid/Prkdcscid
Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz/Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz
NOD.Cg-Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz Prkdcscid/Gck 		abnormal professional antigen presenting cell morphology J:126700
absent T cells J:126700
extended life span J:126700
Prkdcscid/Prkdcscid
Tg(Ins2-Fasl)24Ach/0
NOD.Cg-Prkdcscid Tg(Ins2-Fasl)24Ach 		decreased susceptibility to autoimmune diabetes J:81416
increased susceptibility to autoimmune diabetes J:81416
Prkdcscid/Prkdcscid
Tg(INS-HBEGF*L148S*P149T)70Rin/0
C.BKa-Prkdcscid Tg(INS-HBEGF*L148S*P149T)70Rin 		abnormal pancreatic islet morphology J:204420
decreased circulating insulin level J:204420
decreased pancreatic beta cell number J:204420
hyperglycemia J:204420
Prkdcscid/Prkdcscid
Tg(INS-Il10)#Sar/0
NOD.Cg-Prkdcscid Tg(INS-Il10)#Sar 		increased susceptibility to autoimmune diabetes J:66103
Prkdcscid/Prkdcscid
Tg(LPV-TAg1135)11Tvd/0
involves: C57BL/6J * DBA/2J 		increased thymoma incidence J:47667
premature death J:47667
Prkdcscid/Prkdcscid
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
NOD.Cg-Prkdcscid Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs 		abnormal CD4-positive, alpha beta T cell morphology J:93553
increased susceptibility to autoimmune diabetes J:93553
Prkdcscid/Prkdcscid
Tg(Tcrb)93Vbo/0
involves: Balb/c * C57BL/Ka * C57BL/Lia * CBA/BrA 		abnormal CD4-positive, alpha beta T cell morphology J:111476
abnormal CD8-positive, alpha beta T cell morphology J:111476
abnormal double-positive T cell morphology J:111476
abnormal single-positive T cell number J:111476
abnormal T cell differentiation J:111476
Prkdcscid/Prkdcscid
Tg(TcrLCMV)327Sdz/?
NOD.Cg-Emv30b Prkdcscid Tg(TcrLCMV)327Sdz/DvsJ 		normal immune system phenotype J:71050
Prkdcscid/Prkdcscid
Tgfb1tm1Doe/Tgfb1tm1Doe
involves: 129 * C3H * CF-1 		abnormal intromission J:129629
abnormal spermatid morphology J:129629
abnormal spermatogenesis J:129629
decreased body size J:129629
decreased body weight J:129629
decreased circulating follicle stimulating hormone level J:129629
decreased circulating luteinizing hormone level J:129629
decreased circulating testosterone level J:129629
decreased mounting behavior J:129629
decreased retroperitoneal fat pad weight J:129629
decreased spleen weight J:129629
decreased testes secretion J:129629
failure of copulatory plug deposition J:129629
failure of ejaculation J:129629
increased lung weight J:129629
male infertility J:129629
oligozoospermia J:129629
normal reproductive system phenotype J:129629
small seminiferous tubules J:129629
Prkdcscid/Prkdcscid
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * C57BL/6J 		decreased tumor incidence J:47667
premature death J:47667
Prkdctm1Get/Prkdc+
Rad54ltm1Jhjh/Rad54ltm1Jhjh
involves: 129P2/OlaHsd * C57BL/6 		abnormal chromosome morphology J:84801
decreased telomere length J:84801
Prkdctm1Get/Prkdctm1Get
Rad54ltm1Jhjh/Rad54ltm1Jhjh
involves: 129P2/OlaHsd * C57BL/6 		abnormal chromosome morphology J:84801
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11/12/2024
MGI 6.24 		The Jackson Laboratory