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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Myo6
myosin VI
MGI:104785
87 phenotypes from 14 alleles in 17 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Myo6chl/Myo6chl
involves: C57BL/6JAnu 		abnormal orientation of inner hair cell stereociliary bundles J:196601
abnormal orientation of outer hair cell stereociliary bundles J:196601
abnormal outer hair cell kinocilium morphology J:196601
abnormal vestibular hair cell stereociliary bundle morphology J:196601
abnormal vestibular system physiology J:196601
absent organ of Corti J:196601
absent pinna reflex J:196601
cardiomyopathy J:196601
cochlear ganglion degeneration J:196601
deafness J:196601
decreased inner hair cell stereocilia number J:196601
decreased outer hair cell stereocilia number J:196601
decreased vestibular hair cell number J:196601
fused vestibular hair cell stereocilia J:196601
impaired hearing J:196601
increased heart weight J:196601
increased or absent threshold for auditory brainstem response J:196601
organ of Corti degeneration J:196601
vestibular hair cell degeneration J:196601
Myo6em1(IMPC)Tcp/Myo6em1(IMPC)Tcp
C57BL/6N-Myo6em1(IMPC)Tcp/Tcp 		abnormal auditory brainstem response J:211773
abnormal behavior J:211773
abnormal gait J:211773
abnormal startle reflex J:211773
abnormal sternum morphology J:211773
abnormal stomach morphology J:211773
abnormal uterus morphology J:211773
decreased anxiety-related response J:211773
decreased body length J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased circulating potassium level J:211773
decreased grip strength J:211773
decreased heart rate J:211773
decreased leukocyte cell number J:211773
decreased prepulse inhibition J:211773
decreased startle reflex J:211773
decreased total body fat amount J:211773
enlarged urinary bladder J:211773
head bobbing J:211773
hyperactivity J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating phosphate level J:211773
increased lean body mass J:211773
increased mean corpuscular volume J:211773
prolonged PR interval J:211773
prolonged RR interval J:211773
Myo6em1Bcgen/Myo6+
involves: C57BL/6J * CBA/CaJ 		abnormal cochlear hair cell stereociliary bundle morphology J:288210
abnormal orientation of cochlear hair cell stereociliary bundles J:288210
cochlear hair cell degeneration J:288210
deafness J:288210
impaired balance J:288210
increased or absent threshold for auditory brainstem response J:288210
Myo6em1Bcgen/Myo6em1Bcgen
involves: C57BL/6J * CBA/CaJ 		abnormal cochlear hair cell stereociliary bundle morphology J:288210
abnormal gait J:288210
abnormal inner hair cell stereociliary bundle morphology J:288210
abnormal vestibular hair cell stereociliary bundle morphology J:288210
cochlear hair cell degeneration J:288210
deafness J:288210
fused inner hair cell stereocilia J:288210
head tossing J:288210
hyperactivity J:288210
increased or absent threshold for auditory brainstem response J:288210
Myo6ksv/Myo6ksv
B6JJcl.Cg-Myo6ksv 		abnormal auditory brainstem response waveform shape J:245687
abnormal cochlear hair cell stereociliary bundle morphology J:245687
abnormal cuticular plate morphology J:245687
abnormal inner hair cell stereociliary bundle morphology J:245687
abnormal kinocilium morphology J:245687
abnormal orientation of cochlear hair cell stereociliary bundles J:245687
abnormal vestibular hair cell stereociliary bundle morphology J:245687
circling J:245687
decreased cochlear hair cell stereocilia number J:245687
fused inner hair cell stereocilia J:245687
fused outer hair cell stereocilia J:245687
hyperactivity J:245687
impaired hearing J:245687
Myo6M1Btlr/Myo6M1Btlr
C57BL/6J-Myo6M1Btlr 		bidirectional circling J:161348
head bobbing J:161348
Myo6M1Btlr/Myo6M1Btlr
Not Specified 		bidirectional circling J:165696
head tilt J:165696
Myo6m2Btlr/Myo6m2Btlr
C57BL/6J-Myo6m2Btlr 		circling J:217799
head tossing J:217799
hyperactivity J:217799
Myo6Mhdatlc/Myo6+
C3HeB/FeJ-Myo6Mhdatlc/Ieg 		abnormal cochlear hair cell development J:64900
abnormal cochlear hair cell stereociliary bundle morphology J:64900
abnormal placing response J:64900
absent pinna reflex J:64900
circling J:64900
cochlear hair cell degeneration J:64900
cochlear inner hair cell degeneration J:64900
cochlear outer hair cell degeneration J:64900
head tossing J:64900
impaired balance J:64900
retropulsion J:64900
vestibular hair cell degeneration J:64900
Myo6mpc285H/Myo6mpc285H
involves: BALB/c * C3H/HeH * C57BL/6J 		abnormal inner ear vestibule morphology J:234901
deafness J:234901
Myo6rsv/Myo6rsv
involves: C57BL/6Slc 		abnormal cochlear hair cell stereociliary bundle morphology J:261136
abnormal inner hair cell stereociliary bundle morphology J:261136
abnormal vestibular hair cell stereociliary bundle morphology J:261136
absent pinna reflex J:261136
bidirectional circling J:261136
cochlear ganglion degeneration J:261136
cochlear hair cell degeneration J:261136
cochlear inner hair cell degeneration J:261136
cochlear outer hair cell degeneration J:261136
fused inner hair cell stereocilia J:261136
fused outer hair cell stereocilia J:261136
head tossing J:261136
impaired balance J:261136
increased or absent threshold for auditory brainstem response J:261136
organ of Corti degeneration J:261136
Myo6sv-2J/Myo6sv-2J
B6.Cg-Myo6sv-2J/J 		circling J:109355
deafness J:109355
head tossing J:109355
impaired swimming J:109355
Myo6sv-3J/Myo6sv-3J
C57BL/6J-Myo6sv-3J 		circling J:87349
head tilt J:87349
Myo6sv-4J/Myo6sv-4J
129S1/SvImJ-Myo6sv-4J/J 		circling J:135836
deafness J:135836
head shaking J:135836
head tossing J:135836
increased or absent threshold for auditory brainstem response J:135836
Myo6sv/Myo6+
B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J 		reduced linear vestibular evoked potential J:116914
Myo6sv/Myo6sv
B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J 		abnormal reflex J:116914
absent linear vestibular evoked potential J:116914
circling J:116914
impaired swimming J:116914
Myo6sv/Myo6sv
involves: B10.HA/(33NX)Sn * C57BL/6J 		abnormal cochlear sensory epithelium morphology J:29898
abnormal eye electrophysiology J:134368
absent cochlear nerve compound action potential J:29898
circling J:29898, J:134368
cochlear hair cell degeneration J:29898
cochlear inner hair cell degeneration J:29898
cochlear outer hair cell degeneration J:29898
decreased body size J:86379
fused inner hair cell stereocilia J:58030
fused outer hair cell stereocilia J:58030
head bobbing J:134368
head tossing J:29898
hyperactivity J:29898
organ of Corti degeneration J:29898
reduced fertility J:29898
stereotypic behavior J:29898
normal vision/eye phenotype J:134368
Myo6sv/Myo6sv
involves: B10.HA/(33NX)Sn * SEC/1Gn 		abnormal crista ampullaris neuroepithelium morphology J:5044
abnormal otolithic membrane morphology J:5044
bidirectional circling J:5044
circling J:5044
cochlear degeneration J:5044
cochlear ganglion degeneration J:5044
deafness J:5044
detached tectorial membrane J:5044
head tossing J:5044
hyperactivity J:5044
impaired swimming J:5044
organ of Corti degeneration J:5044
stria vascularis degeneration J:5044
utricular macular degeneration J:5044
vestibular ganglion degeneration J:5044
vestibular hair cell degeneration J:5044
vestibular saccular macula degeneration J:5044
Myo6twt/Myo6twt
involves: C57BL/6J 		abnormal cochlear hair cell stereociliary bundle morphology J:119820
circling J:119820
decreased cochlear hair cell stereocilia number J:119820
decreased startle reflex J:119820
hyperactivity J:119820
impaired swimming J:119820
increased or absent threshold for auditory brainstem response J:119820
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory