About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ltb
lymphotoxin B
MGI:104796
49 phenotypes from 6 alleles in 7 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Ltbtm1Avt/Ltbtm1Avt
involves: 129P2/OlaHsd * C57BL/6 		abnormal adaptive immunity J:79129
abnormal spleen B cell follicle morphology J:79129
abnormal spleen follicular dendritic cell network J:79129
decreased marginal zone B cell number J:79129
decreased spleen germinal center number J:79129
decreased spleen germinal center size J:79129
small Peyer's patches J:79129
Cd19tm1(cre)Cgn/Cd19+
Ltbtm1Avt/Ltbtm1Avt
Tg(Lck-cre)1Jtak/?
involves: 129P2/OlaHsd * C57BL/6 		absent follicular dendritic cells J:79129
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
B6.Cg-Ltb/Tnf/Ltatm1Dvk 		abnormal class switch recombination J:80616
abnormal spleen morphology J:80616
absent axillary lymph nodes J:80616
absent brachial lymph nodes J:80616
absent inguinal lymph nodes J:80616
absent lymph nodes J:80616
absent mesenteric lymph nodes J:80616
absent Peyer's patches J:80616
absent popliteal lymph nodes J:80616
absent spleen germinal center J:80616
absent spleen marginal zone J:80616
decreased IgG level J:80616
decreased spleen B cell follicle number J:80616
decreased spleen white pulp amount J:80616
increased leukocyte cell number J:80616
increased susceptibility to bacterial infection J:80616
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
involves: C57BL/6 		decreased spleen white pulp amount J:109621
Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 		abnormal mesenteric lymph node morphology J:58981
abnormal spleen morphology J:58981
absent axillary lymph nodes J:58981
absent brachial lymph nodes J:58981
absent cervical lymph nodes J:58981
absent follicular dendritic cells J:58981
absent germinal center B cells J:58981
absent inguinal lymph nodes J:58981
absent peripheral lymph nodes J:58981
absent Peyer's patches J:58981
absent popliteal lymph nodes J:58981
absent spleen marginal zone J:58981
intermingled spleen red and white pulp J:58981
Ltbtm1Flv/Ltbtm1Flv
involves: 129S1/Sv * C57BL/6J 		abnormal humoral immune response J:39746
abnormal mesenteric lymph node morphology J:39746
abnormal spleen morphology J:39746
abnormal spleen red pulp morphology J:39746
abnormal spleen white pulp morphology J:39746
absent peripheral lymph nodes J:39746
absent Peyer's patches J:39746
decreased IgA level J:39746
increased susceptibility to xenobiotic induced morbidity/mortality J:91927
Ltbtm1Kpf/Ltbtm1Kpf
B6.129P2-Ltbtm1Kpf 		abnormal class switch recombination J:80616
abnormal colon morphology J:158663
abnormal spleen morphology J:80616
absent spleen marginal zone J:80616
colitis J:158663
decreased IgG level J:80616
decreased spleen B cell follicle number J:80616
decreased spleen white pulp amount J:80616
increased IgM level J:80616
increased leukocyte cell number J:80616
increased susceptibility to bacterial infection J:80616, J:158663
increased susceptibility to bacterial infection induced morbidity/mortality J:158663
weight loss J:158663
Ltbtm1Kpf/Ltbtm1Kpf
involves: 129P2/OlaHsd * C57BL/6 		abnormal liver morphology J:42508
abnormal lung morphology J:42508
abnormal mesenteric lymph node morphology J:42508, J:58981
abnormal spleen follicular dendritic cell network J:42508
abnormal spleen germinal center morphology J:42508
abnormal spleen marginal zone morphology J:42508
abnormal spleen morphology J:42508, J:58981
abnormal spleen red pulp morphology J:42508
absent axillary lymph nodes J:42508
absent brachial lymph nodes J:42508
absent cervical lymph nodes J:58981
absent follicular dendritic cells J:58981
absent inguinal lymph nodes J:42508
absent Peyer's patches J:42508
absent popliteal lymph nodes J:42508
absent spleen marginal zone J:58981
decreased spleen white pulp amount J:109621
increased lymphocyte cell number J:42508
Ltbtm1Krn/Ltbtm1Krn
C57BL/6-Ltbtm1Krn 		abnormal humoral immune response J:78229
abnormal mesenteric lymph node morphology J:78229
abnormal spleen morphology J:78229
absent cervical lymph nodes J:78229
absent peripheral lymph nodes J:78229
absent Peyer's patches J:78229
decreased IgG1 level J:78229
decreased IgG2a level J:78229
increased IgM level J:78229
increased susceptibility to induced morbidity/mortality J:78229
increased susceptibility to parasitic infection J:78229
spleen hyperplasia J:78229
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory