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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tnf
tumor necrosis factor
MGI:104798
294 phenotypes from 29 alleles in 48 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Tnftm2.1Gkl/Tnftm2.1Gkl
involves: 129P2/OlaHsd * 129S/SvEv * 129S6/SvEvTac * C57BL/6J 		normal immune system phenotype J:108572
Lta/Tnftm1Eug/Lta/Tnftm1Eug
B6.129-Lta/Tnftm1Eug 		abnormal sleep pattern J:103266
decreased circulating interferon-gamma level J:115034
decreased IgG1 level J:115034
decreased IgG2a level J:115034
decreased IgG3 level J:115034
decreased interferon-gamma secretion J:115034
decreased susceptibility to induced arthritis J:115034
impaired macrophage phagocytosis J:115034
increased IgM level J:115034
increased susceptibility to bacterial infection J:115034
increased susceptibility to bacterial infection induced morbidity/mortality J:115034
Lta/Tnftm1Eug/Lta/Tnftm1Eug
involves: 129 		abnormal humoral immune response J:31129
abnormal spleen marginal zone morphology J:31129
abnormal spleen morphology J:31129
absent lymph nodes J:31129
absent Peyer's patches J:31129
decreased IgA level J:31129
decreased susceptibility to induced morbidity/mortality J:31129
decreased T cell number J:31129
increased B cell number J:31129
increased leukocyte cell number J:31129
increased susceptibility to bacterial infection J:31129
increased susceptibility to induced morbidity/mortality J:31129
increased susceptibility to Poxviridae infection J:31129
increased susceptibility to Riboviria infection J:31129
Lta/Tnftm1Eug/Lta/Tnftm1Eug
involves: 129 * C57BL/6J 		enlarged liver J:112797
hepatic steatosis J:112797
increased body length J:112797
increased body mass index J:112797
increased body weight J:112797
increased heart weight J:112797
increased liver weight J:112797
increased spleen weight J:112797
increased susceptibility to diet-induced obesity J:112797
long tibia J:112797
Lta/Tnftm1Eug/Lta/Tnftm1Eug
involves: 129/Sv * C57BL/6 		decreased susceptibility to experimental autoimmune encephalomyelitis J:115225
decreased susceptibility to parasitic infection J:37696
increased susceptibility to induced morbidity/mortality J:61314
increased susceptibility to injury J:61314
Lta/Tnftm1Fda/Tnf+
involves: 129S1/Sv * 129X1/SvJ 		decreased susceptibility to endotoxin shock J:39519
decreased tumor necrosis factor secretion J:39519
increased susceptibility to bacterial infection J:39519
Lta/Tnftm1Fda/Lta/Tnftm1Fda
involves: 129S1/Sv * 129X1/SvJ 		decreased susceptibility to endotoxin shock J:39519
decreased tumor necrosis factor secretion J:39519
increased susceptibility to bacterial infection J:39519
Lta/Tnftm1Jods/Lta/Tnftm1Jods
C57BL/6-Lta/Tnftm1Jods 		abnormal spleen white pulp morphology J:78229
decreased susceptibility to experimental autoimmune encephalomyelitis J:47428
Lta/Tnftm1Jods/Lta/Tnftm1Jods
C57BL/6J-Lta/Tnftm1Jods 		abnormal spleen morphology J:43602
absent lymph nodes J:43602
absent Peyer's patches J:43602
decreased immunoglobulin level J:43602
enlarged spleen J:43602
increased leukocyte cell number J:43602
Lta/Tnftm1Jods/Lta/Tnftm1Jods
involves: C57BL/6 		abnormal gamma-delta T cell morphology J:169863
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
B6.Cg-Ltb/Tnf/Ltatm1Dvk 		abnormal class switch recombination J:80616
abnormal spleen morphology J:80616
absent axillary lymph nodes J:80616
absent brachial lymph nodes J:80616
absent inguinal lymph nodes J:80616
absent lymph nodes J:80616
absent mesenteric lymph nodes J:80616
absent Peyer's patches J:80616
absent popliteal lymph nodes J:80616
absent spleen germinal center J:80616
absent spleen marginal zone J:80616
decreased IgG level J:80616
decreased spleen B cell follicle number J:80616
decreased spleen white pulp amount J:80616
increased leukocyte cell number J:80616
increased susceptibility to bacterial infection J:80616
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
involves: C57BL/6 		decreased spleen white pulp amount J:109621
Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 		abnormal mesenteric lymph node morphology J:58981
abnormal spleen morphology J:58981
absent axillary lymph nodes J:58981
absent brachial lymph nodes J:58981
absent cervical lymph nodes J:58981
absent follicular dendritic cells J:58981
absent germinal center B cells J:58981
absent inguinal lymph nodes J:58981
absent peripheral lymph nodes J:58981
absent Peyer's patches J:58981
absent popliteal lymph nodes J:58981
absent spleen marginal zone J:58981
intermingled spleen red and white pulp J:58981
Tg(Ins2-Tnf)17Flv/0
involves: C57BL/6 		decreased CD8-positive, alpha-beta T cell number J:93555
increased CD4-positive, alpha-beta T cell number J:93555
Tg(Ins2-Tnf)17Flv/0
involves: C57BL/6 * CBA 		abnormal pancreatic islet morphology J:91820
insulitis J:91820
Tg(Ins2-Tnf)17Flv/0
involves: C57BL/6 * CBA * NOD 		abnormal pancreatic islet morphology J:91820
normal homeostasis/metabolism phenotype J:91820
normal immune system phenotype J:91820
insulitis J:91820
Tg(Myh6-Tnf)1.6Amf/0
involves: FVB 		abnormal atrioventricular node conduction J:104759
abnormal cardiovascular system morphology J:104759
abnormal cardiovascular system physiology J:104759
abnormal impulse conducting system conduction J:104759
abnormal myocardial fiber physiology J:104759
atrial fibrillation J:104759
cardiac fibrosis J:104759
cardiac hypertrophy J:104759
decreased cardiac muscle contractility J:104759
decreased heart rate J:104759
dilated cardiomyopathy J:104759
dilated heart atrium J:104759
dilated heart ventricle J:104759
increased heart left atrium size J:104759
increased heart ventricle size J:104759
increased heart weight J:104759
irregular heartbeat J:104759
prolonged HV interval J:104759
prolonged QRS complex duration J:104759
prolonged QT interval J:104759
Tg(Myh6-Tnf)1Brgi/?
involves: C57BL/6J * SJL 		abnormal atrial thrombosis J:100006
abnormal heart ventricle morphology J:100006
abnormal motor capabilities/coordination/movement J:100006
abnormal respiration J:100006
cardiac fibrosis J:84829, J:100006
decreased heart ventricle muscle contractility J:100006
decreased locomotor activity J:100006
dilated heart atrium J:100006
globular heart J:100006
hunched posture J:100006
myocarditis J:84829, J:100006
poor grooming J:100006
premature death J:100006
tachypnea J:100006
Tg(Myh6-Tnf)2Brgi/?
involves: C57BL/6J * SJL 		abnormal atrial thrombosis J:100006
abnormal heart ventricle morphology J:100006
abnormal motor capabilities/coordination/movement J:100006
abnormal respiration J:100006
cardiac fibrosis J:84829, J:100006
decreased heart ventricle muscle contractility J:100006
decreased locomotor activity J:100006
dilated heart atrium J:100006
globular heart J:100006
hunched posture J:100006
myocarditis J:84829, J:100006
poor grooming J:100006
premature death J:100006
tachypnea J:100006
Tg(SFTPC-rtTA,tetO-Tnf)320-1Gwho/0
involves: C57BL/6 * SJL 		abnormal B cell morphology J:97297
abnormal bronchus-associated lymphoid tissue morphology J:97297
abnormal CD4-positive, alpha beta T cell morphology J:97297
abnormal dendritic cell morphology J:97297
abnormal T cell morphology J:97297
emphysema J:97297
increased CD8-positive, alpha-beta T cell number J:97297
increased lymphocyte cell number J:97297
increased neutrophil cell number J:97297
lung inflammation J:97297
pulmonary fibrosis J:97297
Tg(SFTPC-Tnf)2Pva/0
involves: C57BL/6 * DBA/2 		abnormal blood coagulation J:28120
abnormal lung morphology J:28120
abnormal lung vasculature morphology J:28120
abnormal platelet cell number J:28120
abnormal pulmonary alveolar system morphology J:28120
abnormal pulmonary alveolus epithelium morphology J:28120
abnormal pulmonary alveolus wall morphology J:222067
abnormal pulmonary interalveolar septum morphology J:28120
abnormal respiratory system morphology J:222067
abnormal type II pneumocyte morphology J:28120
alveolitis J:28120
cyanosis J:28120
emphysema J:222067
increased collagen level J:222067
increased hyaluronic acid level J:222067
increased pulmonary alveolus wall thickness J:28120
interstitial pneumonia J:28120
lung hemorrhage J:28120
premature death J:28120
pulmonary fibrosis J:28120, J:222067
respiratory distress J:28120
respiratory failure J:28120
thick pulmonary interalveolar septum J:28120
Tg(Tek-Tnf*)5382Mcla/0
B6.Cg-Tg(Tek-Tnf*)5382Mcla 		chronic inflammation J:71622
chronic liver inflammation J:71622
decreased inflammatory response J:71622
kidney inflammation J:71622
lung inflammation J:71622
Tg(Tnf)6074Gkl/0
involves: C57BL/6 * CBA 		abnormal astrocyte morphology J:106592
abnormal meninges morphology J:106592
abnormal microglial cell morphology J:106592
abnormal nervous system physiology J:106592
abnormal oligodendrocyte apoptosis J:106592
axon degeneration J:106592
brain inflammation J:106592
demyelination J:106592
impaired blood-brain barrier function J:106592
TnfBpsm1/Tnf+
C.Cg-TnfBpsm1 		aortic aneurysm J:226052
aortic valve inflammation J:226052
cardiac fibrosis J:226052
cardiac valve regurgitation J:226052
cardiovalvulitis J:226052
mitral valve inflammation J:226052
premature death J:226052
thick aortic valve J:226052
thick mitral valve J:226052
TnfBpsm1/Tnf+
involves: C57BL/6 		abnormal limb morphology J:226052
abnormal rib joint morphology J:226052
abnormal spine curvature J:226052
abnormal thoracic vertebrae morphology J:226052
aortic aneurysm J:226052
aortic valve inflammation J:226052
decreased grip strength J:226052
hindlimb paralysis J:226052
increased circulating tumor necrosis factor level J:226052
joint dislocation J:226052
kyphosis J:226052
mitral valve inflammation J:226052
normal mortality/aging J:226052
rheumatoid arthritis J:226052
TnfBpsm1/TnfBpsm1
involves: C57BL/6 		abnormal wrist joint morphology J:226052
accelerated temporomandibular joint osteoarthritis J:226052
aortic aneurysm J:226052
aortic valve inflammation J:226052
increased circulating tumor necrosis factor level J:226052
joint dislocation J:226052
limb paralysis J:226052
mitral valve inflammation J:226052
normal mortality/aging J:226052
rheumatoid arthritis J:226052
Tnfem4Boui/Tnf+
C57BL/6-Tnfem4Boui 		autoimmune arthritis J:306876
cardiovalvulitis J:306876
colitis J:306876
esophageal inflammation J:306876
ileum inflammation J:306876
premature death J:306876
Tnfem4Boui/Tnfem4Boui
C57BL/6-Tnfem4Boui 		abnormal embryo morphology J:306876
decreased embryo size J:306876
lethality throughout fetal growth and development, complete penetrance J:306876
Tnfem5Boui/Tnfem5Boui
C57BL/6-Tnfem5Boui 		prenatal lethality, complete penetrance J:306876
TnfM1Btlr/Tnf+
C57BL/6J-TnfM1Btlr 		decreased follicular dendritic cell number J:124642
normal immune system phenotype J:124642
TnfM1Btlr/TnfM1Btlr
C57BL/6J-TnfM1Btlr 		decreased follicular dendritic cell number J:124642
normal immune system phenotype J:124642
increased susceptibility to bacterial infection J:124642
TnfM2Btlr/Tnf+
C57BL/6J-TnfM2Btlr 		decreased macrophage cytokine production J:213047
decreased tumor necrosis factor secretion J:213047
TnfR8H/TnfR8H
involves: I/St 		increased susceptibility to bacterial infection J:114302
increased susceptibility to induced morbidity/mortality J:114302
Tnftm1.1Sned/Tnftm1.1Sned
Cd19tm1(cre)Cgn/Cd19+
involves: 129 * 129P2/OlaHsd * C57BL/6 		normal immune system phenotype J:95684
Tnftm1.1Sned/Tnftm1.1Sned
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129 * 129P2/OlaHsd * C57BL/6 		abnormal chemokine secretion J:95684
decreased circulating tumor necrosis factor level J:95684
decreased susceptibility to autoimmune disorder J:95684
decreased susceptibility to endotoxin shock J:95684
hepatic necrosis J:95684
increased susceptibility to bacterial infection J:95684
increased susceptibility to induced morbidity/mortality J:95684
Tnftm1.1Sned/Tnftm1.1Sned
Tg(Cd4-cre)1Cwi/0
involves: 129 * C57BL/6 * DBA/2 		decreased circulating tumor necrosis factor level J:95684
decreased susceptibility to autoimmune disorder J:95684
decreased susceptibility to endotoxin shock J:95684
increased susceptibility to bacterial infection J:95684
increased susceptibility to induced morbidity/mortality J:95684
Tnftm1.2Sned/Tnftm1.2Sned
involves: 129/Sv * C57BL/6 		absent Peyer's patches J:97783
decreased susceptibility to bacterial infection J:97783
increased leukocyte cell number J:97783
increased susceptibility to parasitic infection J:97783
Tnftm1Gkl/Tnftm1Gkl
B6;129S-Tnftm1Gkl/J 		abnormal spermatogenesis J:143457
abnormal spermiation J:143457
abnormal testis physiology J:143457
decreased testes secretion J:143457
decreased testis weight J:143457
oligozoospermia J:143457
Tnftm1Gkl/Tnftm1Gkl
C.129S-Tnftm1Gkl 		decreased incidence of tumors by chemical induction J:56068
Tnftm1Gkl/Tnftm1Gkl
either: B6.129-Tnftm1Gkl or (involves: 129 * C57BL/6) 		decreased Peyer's patch number J:97783
decreased susceptibility to bacterial infection J:97783
increased leukocyte cell number J:97783
increased lymphocyte cell number J:97783
increased neutrophil cell number J:97783
increased susceptibility to parasitic infection J:97783
small Peyer's patches J:97783
Tnftm1Gkl/Tnftm1Gkl
involves: 129S/SvEv 		abnormal chemokine secretion J:95684
decreased circulating tumor necrosis factor level J:95684
decreased susceptibility to autoimmune disorder J:95684
decreased susceptibility to endotoxin shock J:95684
increased susceptibility to bacterial infection J:95684
Tnftm1Gkl/Tnftm1Gkl
involves: 129S/SvEv * C57BL/6 		abnormal fat pad morphology J:42579
abnormal glucose homeostasis J:42579
abnormal inflammatory response J:114740
abnormal lipid homeostasis J:42579
abnormal lymph node B cell domain morphology J:40970
abnormal lymphocyte physiology J:114740
abnormal macrophage physiology J:114740
abnormal mesenteric lymph node morphology J:114740
abnormal Peyer's patch follicle morphology J:40970
abnormal Peyer's patch morphology J:40970
abnormal spleen follicular dendritic cell network J:42579
abnormal spleen primary B follicle morphology J:47673
abnormal trabecular bone morphology J:135519
absent follicular dendritic cells J:40970
absent spleen germinal center J:47673, J:114740
alveolar process atrophy J:147935
decreased body weight J:42579
decreased circulating glucose level J:42579
decreased circulating insulin level J:42579
decreased circulating leptin level J:42579
decreased circulating triglyceride level J:42579
decreased incidence of tumors by chemical induction J:56068
decreased inflammatory response J:56068
decreased keratinocyte proliferation J:56068
decreased percent body fat/body weight J:42579
decreased Peyer's patch number J:40970
decreased susceptibility to experimental autoimmune encephalomyelitis J:114740
decreased susceptibility to type IV hypersensitivity reaction J:47673
normal immune system phenotype J:114740
increased bone mineral density J:135519
increased osteoblast cell number J:135519
increased susceptibility to bacterial infection J:47673, J:114740
Tnftm1Gkl/Tnftm1Gkl
involves: 129S/SvEv * C57BL/6J 		abnormal metallophilic macrophage morphology J:124642
abnormal Peyer's patch follicle morphology J:124642
abnormal Peyer's patch germinal center morphology J:124642
abnormal Peyer's patch morphology J:124642
abnormal Peyer's patch T cell area morphology J:124642
abnormal spleen follicular dendritic cell network J:124642
abnormal spleen marginal sinus morphology J:124642
abnormal spleen primary B follicle morphology J:124642
absent spleen germinal center J:124642
decreased Peyer's patch number J:124642
increased susceptibility to bacterial infection J:124642
Tnftm1Gkl/Tnftm2Gkl
involves: 129S/SvEv * C57BL/6 		increased circulating tumor necrosis factor level J:54056
increased susceptibility to endotoxin shock J:54056
increased tumor necrosis factor secretion J:54056
rheumatoid arthritis J:54056
Tnftm1Jods/Tnftm1Jods
C57BL/6-Ltatm1Jods 		abnormal spleen B cell follicle morphology J:78229
decreased susceptibility to experimental autoimmune encephalomyelitis J:47428
Tnftm1Jods/Tnftm1Jods
C57BL/6-Tnftm1Jods 		abnormal cytokine level J:118417
decreased susceptibility to experimental autoimmune encephalomyelitis J:118417
Tnftm1Jods/Tnftm1Jods
involves: C57BL/6 		abnormal immune system physiology J:98591
abnormal lymph node primary follicle morphology J:98591
abnormal metallophilic macrophage morphology J:98591
abnormal Peyer's patch follicle morphology J:43602
abnormal Peyer's patch morphology J:43602, J:98591
abnormal spleen marginal sinus morphology J:43602
abnormal spleen primary B follicle morphology J:43602, J:98591
abnormal spleen white pulp morphology J:43602, J:98591
absent spleen germinal center J:98591
decreased follicular dendritic cell number J:43602
decreased Peyer's patch number J:43602
decreased susceptibility to endotoxin shock J:98591
decreased susceptibility to experimental autoimmune encephalomyelitis J:44545, J:98591
increased leukocyte cell number J:43602
increased susceptibility to bacterial infection J:98170, J:115034
small Peyer's patches J:43602
Tnftm1Ljo/Tnf+
involves: 129S1/Sv 		increased susceptibility to bacterial infection J:41992
increased susceptibility to fungal infection J:41992
Tnftm1Ljo/Tnftm1Ljo
B6.129S1-Tnftm1Ljo 		abnormal cerebral cortex morphology J:120489
abnormal long-term spatial reference memory J:120489
abnormal lung morphology J:127028
abnormal motor coordination/balance J:120489
decreased apoptosis J:127028
impaired coordination J:120489
lung inflammation J:127028
Tnftm1Ljo/Tnftm1Ljo
either: B6.129-Tnftm1Ljo or (involves: 129 * C57BL/6) 		abnormal Peyer's patch follicle morphology J:97783
abnormal Peyer's patch germinal center morphology J:97783
abnormal Peyer's patch T cell area morphology J:97783
absent follicular dendritic cells J:97783
decreased Peyer's patch number J:97783
decreased susceptibility to bacterial infection J:97783
increased leukocyte cell number J:97783
increased lymphocyte cell number J:97783
increased neutrophil cell number J:97783
increased susceptibility to parasitic infection J:97783
small Peyer's patches J:97783
Tnftm1Ljo/Tnftm1Ljo
involves: 129S1/Sv 		abnormal chemokine secretion J:95684
abnormal cytokine secretion J:41992
abnormal follicular dendritic cell physiology J:41992
abnormal susceptibility to infection J:41992
absent spleen germinal center J:41992, J:80616
decreased circulating tumor necrosis factor level J:95684
decreased IgG level J:41992
decreased spleen B cell follicle number J:95684
decreased spleen white pulp amount J:80616
decreased susceptibility to autoimmune disorder J:95684
decreased susceptibility to endotoxin shock J:41992, J:95684
increased susceptibility to bacterial infection J:41992, J:80616, J:95684
increased susceptibility to fungal infection J:41992
Tnftm1Ljo/Tnftm1Ljo
involves: 129S1/Sv * C57BL/6 		abnormal lymph node cell ratio J:127028
abnormal neutrophil physiology J:127028
decreased immunoglobulin level J:127028
increased interferon-gamma secretion J:127028
increased neutrophil cell number J:127028
increased susceptibility to parasitic infection J:127028
lymph node hypoplasia J:127028
skin inflammation J:127028
skin lesions J:127028
Tnftm1Ljo/Tnftm1Ljo
involves: 129S1/Sv * C57BL/6J 		normal liver/biliary system phenotype J:112797
Tnftm1Sek/Tnftm1Sek
B6.Cg-Tnftm1Sek 		abnormal cytokine secretion J:44841
abnormal macrophage physiology J:44841
abnormal mesenteric lymph node morphology J:44841
abnormal Peyer's patch germinal center morphology J:44841
absent lymph node germinal center J:44841
absent spleen germinal center J:44841
decreased circulating interferon-gamma level J:44841
decreased circulating interleukin-1 alpha level J:44841
decreased circulating interleukin-1 beta level J:44841
decreased circulating interleukin-6 level J:44841
decreased coping response J:102967
decreased locomotor activity J:102967
decreased susceptibility to endotoxin shock J:44841
decreased vertical activity J:102967
normal immune system phenotype J:44841
increased anxiety-related response J:102967
increased grooming behavior J:102967
increased serotonin level J:102967
Tnftm1Sek/Tnftm1Sek
involves: C57BL/6 * CBA 		abnormal female reproductive system physiology J:59892
abnormal liver physiology J:120559
abnormal vagina weight J:114219
prolonged estrus J:114219
Tnftm2.1Gkl/Tnf+
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S/SvEv * 129S6/SvEvTac * C57BL/6J 		weight loss J:108572
Tnftm2.1Gkl/Tnftm2.1Gkl
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J 		weight loss J:108572
Tnftm2.1Gkl/Tnftm2.1Gkl
Tg(Fabp1-cre)1Jig/0
involves: 129S/SvEv * FVB/N 		abnormal intestinal mucosa morphology J:204557
abnormal small intestinal villus morphology J:204557
decreased small intestinal villus number J:204557
ileum inflammation J:204557
increased circulating tumor necrosis factor level J:204557
large intestinal inflammation J:204557
small intestinal inflammation J:204557
Tnftm2.1Gkl/Tnftm2.1Gkl
Tg(Lck-cre)I57Jxm/0
involves: 129S/SvEv * ICR 		small intestinal inflammation J:108572
Tnftm2Gkl/Tnf+
B6.129S-Tnftm2Gkl/Jarn 		abnormal CD4-positive, alpha-beta T cell physiology J:145626
abnormal CD8-positive, alpha beta T cell morphology J:131978
ileum inflammation J:131978, J:145626
increased CD4-positive, alpha-beta memory T cell number J:145626
increased CD4-positive, alpha-beta T cell number J:145626
increased interferon-gamma secretion J:131978
increased interleukin-2 secretion J:145626
increased tumor necrosis factor secretion J:145626
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * C57BL/6 		abnormal alpha-beta intraepithelial T cell morphology J:136667
abnormal CD4-positive, alpha-beta T cell physiology J:136667
abnormal CD8-positive, alpha beta T cell morphology J:136667
abnormal circulating chemokine level J:204922
abnormal circulating leptin level J:204922
abnormal food intake J:204922
abnormal glucose homeostasis J:204922
abnormal intestine physiology J:204922
abnormal T cell physiology J:136667
abnormal T cell subpopulation ratio J:136667
abnormal T-helper 17 cell physiology J:204922
alopecia J:92307
autoimmune arthritis J:92307, J:136667
decreased inflammatory response J:204922
decreased susceptibility to diet-induced obesity J:204922
ileum inflammation J:204922
increased circulating tumor necrosis factor level J:54056, J:204922
increased dendritic cell number J:204922
intestinal inflammation J:136667
rheumatoid arthritis J:54056
small intestinal inflammation J:54056, J:92307, J:204922
steatorrhea J:204922
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * C57BL/6 * CBA 		autoimmune arthritis J:131930
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * C57BL/6 * SPRET/Ei 		alopecia J:92307
autoimmune arthritis J:92307
small intestinal inflammation J:92307
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * C57BL/6J 		abnormal aorta bulb morphology J:264147
abnormal aortic valve flow J:264147
abnormal aortic valve morphology J:264147
abnormal cytotoxic T cell physiology J:108572
abnormal joint morphology J:264147
abnormal myelopoiesis J:108572
abnormal response to transplant J:108572
aortic valve stenosis J:264147
cardiac fibrosis J:264147
decreased cardiac output J:264147
decreased heart left ventricle muscle contractility J:264147
decreased heart rate J:264147
enhanced wound healing J:264147
enlarged spleen J:108572
increased apoptosis J:108572
increased CD8-positive, alpha-beta T cell number J:108572
increased cell migration J:264147
increased cell proliferation J:264147
increased circulating tumor necrosis factor level J:264147
increased fibroblast cell migration J:264147
increased fibroblast proliferation J:264147
increased tumor necrosis factor secretion J:264147
prolonged QT interval J:264147
small intestinal inflammation J:108572
thick aortic valve cusps J:264147
Tnftm2Gkl/Tnftm2Gkl
involves: 129S/SvEv * C57BL/6 		cardiovalvulitis J:226052
decreased body weight J:54056
increased circulating tumor necrosis factor level J:54056
premature death J:54056
rheumatoid arthritis J:54056
small intestinal inflammation J:54056
thymus hypoplasia J:54056
Tnftm2Jods/Tnftm2Jods
C57BL/6-Tnftm2Jods 		abnormal immune system physiology J:98591
abnormal lymph node primary follicle morphology J:98591
abnormal metallophilic macrophage morphology J:98591
abnormal Peyer's patch follicle morphology J:98591
abnormal spleen follicular dendritic cell network J:98591
abnormal spleen primary B follicle morphology J:98591
abnormal spleen white pulp morphology J:98591
decreased spleen germinal center number J:98591
decreased spleen germinal center size J:98591
decreased susceptibility to endotoxin shock J:98591
decreased susceptibility to experimental autoimmune encephalomyelitis J:98591
Tnftm2Jods/Tnftm2Jods
involves: C57BL/6 		abnormal lymph node cell ratio J:127028
decreased immunoglobulin level J:127028
normal immune system phenotype J:127028
increased susceptibility to bacterial infection J:98170
Tnftm2Jods/Tnftm2Jods
involves: C57BL/6 * C57BL/6J 		decreased liver free fatty acids level J:112797
Tnftm3Gkl/Tnftm3Gkl
involves: 129S/SvEv * C57BL/6 		abnormal lymph node B cell domain morphology J:114740
abnormal lymphocyte physiology J:114740
abnormal mesenteric lymph node morphology J:114740
abnormal spleen primary B follicle morphology J:114740
absent follicular dendritic cells J:114740
absent spleen germinal center J:114740
autoimmune response J:114740
decreased circulating tumor necrosis factor level J:114740
decreased IgG1 level J:114740
decreased susceptibility to bacterial infection J:114740
decreased susceptibility to endotoxin shock J:114740
decreased susceptibility to experimental autoimmune encephalomyelitis J:114740
decreased tumor necrosis factor secretion J:114740
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory