Tnf Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tnf
tumor necrosis factor
MGI:104798

101 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
B2m^tm1Jae/B2m^tm1Jae Tnf^tm2Gkl/Tnf⁺ involves: 129S/SvEv * 129S2/SvPas * C57BL/6J	small intestinal inflammation	J:108572
Ccl25^tm1.1Mal/Ccl25^tm1.1Mal Tnf^tm2Gkl/Tnf⁺ involves: 129S/SvEv * 129S2/SvPas * C57BL/6	abnormal alpha-beta intraepithelial T cell morphology	J:136667
	abnormal T cell subpopulation ratio	J:136667
	decreased gamma-delta intraepithelial T cell number	J:136667
	intestinal inflammation	J:136667
Ccr9^tm1.1Mal/Ccr9^tm1.1Mal Tnf^tm2Gkl/Tnf⁺ involves: 129S/SvEv * 129S2/SvPas * C57BL/6	abnormal alpha-beta intraepithelial T cell morphology	J:136667
	abnormal T cell subpopulation ratio	J:136667
	decreased gamma-delta intraepithelial T cell number	J:136667
	intestinal inflammation	J:136667
Cd4^tm1Mak/Cd4^tm1Mak Tnf^tm2Gkl/Tnf⁺ involves: 129S/SvEv * 129S2/SvPas * C57BL/6J	premature death	J:108572
	small intestinal inflammation	J:108572
Cd44^tm1Hbg/Cd44⁺ Tnf^tm2Gkl/Tnf⁺ involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6	ileum inflammation	J:145626
Cd44^tm1Hbg/Cd44^tm1Hbg Tnf^tm2Gkl/Tnf⁺ involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6	normal digestive/alimentary phenotype	J:145626
	normal immune system phenotype	J:145626
Cyp2g1^{tm1(rtTA)Lane}/Cyp2g1⁺ Tg(SFTPC-rtTA,tetO-Tnf)320-1Gwho/0 involves: 129 * C57BL/6 * SJL	abnormal olfactory epithelium morphology	J:157842
	abnormal olfactory sensory neuron morphology	J:157842
	anosmia	J:157842
	decreased cell proliferation	J:157842
	impaired olfaction	J:157842
	increased macrophage cell number	J:157842
	rhinitis	J:157842
Fadd^tm1Mpa/Fadd^tm1Mpa Tnf^tm1Gkl/Tnf^tm1Gkl Tg(Vil1-cre)997Gum/0 B6.Cg-Fadd^tm1Mpa Tnf^tm1Gkl Tg(Vil1-cre)997Gum	cecum inflammation	J:175865
	colitis	J:175865
	decreased Paneth cell number	J:175865
Ifng^tm1Ts/Ifng^tm1Ts Tnf^tm2Gkl/Tnf⁺ involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J	small intestinal inflammation	J:108572
Ighm^tm1Cgn/Ighm^tm1Cgn Tnf^tm2Gkl/Tnf⁺ involves: 129S/SvEv * 129S2/SvPas * C57BL/6J	small intestinal inflammation	J:108572
Il12b^tm1Jm/Il12b^tm1Jm Tnf^tm2Gkl/Tnf⁺ involves: 129S/SvEv * 129S1/Sv * C57BL/6J	small intestinal inflammation	J:108572
Irak1^tm1Jth/Irak1^tm1Jth Tg(Myh6-Tnf)1Brgi/? involves: 129/Sv * C57BL/6J * SJL	abnormal heart morphology	J:84829
	normal mortality/aging	J:84829
	myocardial fiber degeneration	J:84829
	myocarditis	J:84829
Irak1^tm1Jth/Y Tg(Myh6-Tnf)1Brgi/? involves: 129/Sv * C57BL/6J * SJL	abnormal heart morphology	J:84829
	normal mortality/aging	J:84829
	myocardial fiber degeneration	J:84829
	myocarditis	J:84829
Itgb7^tm1Cgn/Itgb7^tm1Cgn Tnf^tm2Gkl/Tnf⁺ involves: 129S/SvEv * C57BL/6	abnormal inflammatory response	J:136667
	autoimmune arthritis	J:136667
Krt8^tm1Rgo/Krt8^tm1Rgo Tnf^tm1Gkl/Tnf^tm1Gkl involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * FVB/N	normal mortality/aging	J:121811
	prenatal lethality, incomplete penetrance	J:121811
Map3k8^tm1Pnt/Map3k8^tm1Pnt Tnf^tm2Gkl/Tnf⁺ involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J	increased CD8-positive, alpha-beta T cell number	J:108572
	increased single-positive T cell number	J:108572
	small intestinal inflammation	J:108572
Mapk9^tm1Flv/Mapk9^tm1Flv Tnf^tm2Gkl/Tnf⁺ involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J	normal immune system phenotype	J:108572
	increased apoptosis	J:108572
	small intestinal inflammation	J:108572
Mapk11^tm1Jsca/Mapk11^tm1Jsca Tnf^tm2Gkl/Tnf⁺ involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	autoimmune arthritis	J:107771
	ileum inflammation	J:107771
Mapkapk2^tm1Mgl/Mapkapk2^tm1Mgl Tnf^tm2Gkl/Tnf⁺ involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J	decreased apoptosis	J:108572
	granulomatous inflammation	J:108572
	normal immune system phenotype	J:108572
	premature death	J:108572
	small intestinal inflammation	J:108572
Mertk^nmf12/Mertk^nmf12 Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk involves: C57BL/6J	abnormal retina morphology	J:175587
	retina photoreceptor degeneration	J:175587
	thin retina inner nuclear layer	J:175587
	thin retina outer nuclear layer	J:175587
Nfkb1^tm1Bal/Nfkb1^tm1Bal Rela^tm1Bal/Rela^tm1Bal Tnf^tm1Ljo/Tnf^tm1Ljo involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae	neonatal lethality, complete penetrance	J:91366
	prenatal lethality, incomplete penetrance	J:91366
	thin epidermis	J:91366
Nfkbiz^tm1Aki/Nfkbiz^tm1Aki Tnf^tm1Sek/Tnf^tm1Sek involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj	conjunctivitis	J:194832
	dermatitis	J:194832
	eyelid edema	J:194832
Nos2^tm1Mrl/Nos2^tm1Mrl Tg(Myh6-Tnf)1.6Amf/? involves: 129S7/SvEvBrd * C57BL/6 * FVB	abnormal atrioventricular node conduction	J:109732
	abnormal cardiac muscle contractility	J:109732
	abnormal heart electrocardiography waveform feature	J:109732
	abnormal heart ventricle pressure	J:109732
	abnormal myocardial fiber physiology	J:109732
	decreased cardiac muscle contractility	J:109732
	decreased heart rate	J:109732
	irregular heartbeat	J:109732
Rag1^tm1Mom/Rag1^tm1Mom Tnf^tm2Gkl/Tnf⁺ involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6	rheumatoid arthritis	J:54056
	small intestinal inflammation	J:54056
Rel^tm1Grd/Rel^tm1Grd Rela^tm1Bal/Rela^tm1Bal Tnf^tm1Ljo/Tnf^tm1Ljo involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae	abnormal cell cycle	J:91366
	abnormal epidermal layer morphology	J:91366
	abnormal epidermis stratum basale morphology	J:91366
	abnormal hair follicle placode formation	J:91366
	abnormal keratinocyte morphology	J:91366
	decreased cell proliferation	J:91366
	decreased embryo size	J:91366
	decreased hair follicle number	J:91366
	neonatal lethality, complete penetrance	J:91366
	thin epidermis	J:91366
	underdeveloped hair follicles	J:91366
Rela^tm1Bal/Rela^tm1Bal Tnf^tm1Ljo/Tnf^tm1Ljo involves: 129S1/Sv * 129S4/SvJae * C57BL/6	abnormal nervous system physiology	J:124444
Rela^tm1Yuo/Rela^tm1Yuo Tnf^tm1Ljo/Tnf^tm1Ljo involves: 129S/SvEv * 129S1/Sv	abnormal myogenesis	J:135692
	decreased skeletal muscle fiber diameter	J:135692
	increased skeletal muscle fiber number	J:135692
Rigi^tm1Aki/Rigi^tm1Aki Tnf^tm1Sek/Tnf^tm1Sek involves: C57BL/6 * CBA	postnatal lethality	J:100539
Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro Tnf^tm1Gkl/Tnf^tm1Gkl involves: 129S/SvEv * 129S4/SvJae * BALB/cJ * C57BL/6J	abnormal osteoclast differentiation	J:117880
	normal immune system phenotype	J:117880
	normal skeleton phenotype	J:117880
Stat3^tm2Aki/Stat3^tm2Aki Tnf^tm1Sek/Tnf^tm1Sek Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * C57BL/6 * CBA	colitis	J:83280
	increased interferon-gamma secretion	J:83280
	increased interleukin-6 secretion	J:83280
	increased interleukin-12b secretion	J:83280
Tbk1^tm1Aki/Tbk1^tm1Aki Tnf^tm1Sek/Tnf^tm1Sek involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal cytotoxic T cell physiology	J:132662
	decreased cytotoxic T cell cytolysis	J:132662
	decreased IgG1 level	J:132662
	decreased IgG2a level	J:132662
	decreased IgG level	J:132662
	decreased interferon-gamma secretion	J:132662
	normal mortality/aging	J:132662
Tcrd^tm1Mom/Tcrd^tm1Mom Tnf^tm2Gkl/Tnf⁺ involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J	small intestinal inflammation	J:108572
Tg(Ins2-CD80)3B7Flv/0 Tg(Ins2-Tnf)17Flv/0 involves: C57BL/6 * CBA/Ca	abnormal cytokine secretion	J:93555
	increased circulating glucose level	J:93555
	increased susceptibility to autoimmune diabetes	J:93555
Tg(Ins2-CD86)12B70Flv/0 Tg(Ins2-Tnf)17Flv/0 involves: C57BL/6 * CBA/Ca	abnormal cytokine secretion	J:93555
	increased circulating glucose level	J:93555
	increased susceptibility to autoimmune diabetes	J:93555
Tg(Tnf)6074Gkl/0 Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm involves: 129S2/SvPas * C57BL/6 * CBA	abnormal oligodendrocyte apoptosis	J:106592
	CNS inflammation	J:106592
	demyelination	J:106592
Timp3^tm1Rkho/Timp3^tm1Rkho Tnf^tm1Gkl/Tnf^tm1Gkl involves: 129 * 129S/SvEv * C57BL/6	decreased heart ventricle muscle contractility	J:112033
	dilated heart left ventricle	J:112033
	increased neutrophil cell number	J:112033
Tnf^Bpsm1/Tnf⁺ Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak involves: 129S2/SvPas * C57BL/6	increased circulating tumor necrosis factor level	J:226052
	normal skeleton phenotype	J:226052
Tnf^Bpsm1/Tnf^Bpsm1 Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak involves: 129S2/SvPas * C57BL/6	increased circulating tumor necrosis factor level	J:226052
	normal skeleton phenotype	J:226052
Tnf^em5Boui/Tnf⁺ Tnfrsf1a^tm1Mak/Tnfrsf1a⁺ involves: 129S2/SvPas * C57BL/6	abnormal lung morphology	J:306876
	autoimmune arthritis	J:306876
	cardiovalvulitis	J:306876
	colitis	J:306876
	premature death	J:306876
	preweaning lethality, incomplete penetrance	J:306876
Tnf^tm1Gkl/Tnf^tm1Gkl Tnfaip3^tm1Ama/Tnfaip3^tm1Ama involves: 129S/SvEv * C57BL/6J	abnormal cytokine secretion	J:92694
	abnormal inflammatory response	J:92694
	cachexia	J:92694
	premature death	J:92694
Tnf^tm1Gkl/Tnf^tm1Gkl Tnfrsf1a^tm1.1Gkl/Tnfrsf1a^tm1.1Gkl involves: 129S/SvEv * C57BL/6	normal immune system phenotype	J:92470
Tnf^tm1Gkl/Tnf^tm1Gkl Zfp36^tm1Pjb/Zfp36^tm1Pjb involves: 129S/SvEv * C57BL/6	abnormal vasodilation	J:214114
	oxidative stress	J:214114
Tnf^tm1Ljo/Tnf⁺ Tnip1^tm1.1Ama/Tnip1^tm1.1Ama involves: 129S1/Sv * C57BL/6J	perinatal lethality, incomplete penetrance	J:145539
Tnf^tm1Ljo/Tnf^tm1Ljo Tnip1^tm1.1Ama/Tnip1^tm1.1Ama involves: 129S1/Sv * C57BL/6J	normal mortality/aging	J:145539
Tnf^tm2Gkl/Tnf⁺ Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm involves: 129S/SvEv * 129S2/SvPas * C57BL/6	rheumatoid arthritis	J:54056
	small intestinal inflammation	J:54056
Tnf^tm2Gkl/Tnf⁺ Tnfrsf1a^tm2Gkl/Tnfrsf1a^tm2Gkl Tg(Col6a1-cre)1Gkl/0 involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA	normal cardiovascular system phenotype	J:264147
Tnf^tm2Gkl/Tnf⁺ Tnfrsf1a^tm2Gkl/Tnfrsf1a^tm2Gkl Tg(Col6a1-cre)1Gkl/? involves: 129S/SvEv * C57BL/6 * CBA	autoimmune arthritis	J:131930
	small intestinal inflammation	J:131930
Tnf^tm2Gkl/Tnf⁺ Tnfrsf1b^tm1.1Gkl/Tnfrsf1b^tm1.1Gkl Tg(Col6a1-cre)1Gkl/0 involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA	abnormal cell adhesion	J:264147
	abnormal cell physiology	J:264147
	abnormal fibroblast physiology	J:264147
	abnormal wound healing	J:264147
	normal cardiovascular system phenotype	J:264147
	increased circulating tumor necrosis factor level	J:264147
	increased tumor necrosis factor secretion	J:264147
	joint inflammation	J:264147
Tnf^tm2Gkl/Tnf⁺ Tnfrsf1b^tm1.2Gkl/Tnfrsf1b^tm1.2Gkl involves: 129S/SvEv * C57BL/6 * C57BL/6J	abnormal cell adhesion	J:264147
	abnormal cell physiology	J:264147
	abnormal fibroblast physiology	J:264147
	abnormal wound healing	J:264147
	aortic valve inflammation	J:264147
	aortic valve stenosis	J:264147
	autoimmune arthritis	J:264147
	cardiac fibrosis	J:264147
	increased circulating tumor necrosis factor level	J:264147
	increased tumor necrosis factor secretion	J:264147
Tnf^tm2Gkl/Tnf^tm2Gkl Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	increased circulating tumor necrosis factor level	J:54056
	increased tumor necrosis factor secretion	J:54056
Tnf^tm3Gkl/Tnf^tm3Gkl Zfp36^tm1Pjb/Zfp36^tm1Pjb involves: 129S/SvEv * C57BL/6	normal immune system phenotype	J:114740
	myeloid hyperplasia	J:114740

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