Ier3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ier3
immediate early response 3
MGI:104814

23 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ier3^tm1Mxw/Ier3^tm1Mxw involves: 129 * C57BL/6	abnormal CD4-positive, alpha-beta T cell physiology	J:157504
	abnormal interleukin level	J:157504
	abnormal macrophage physiology	J:157504
	abnormal response to infection	J:157504
	abnormal tumor necrosis factor level	J:157504
	abnormal tumor necrosis factor secretion	J:157504
	decreased regulatory T cell number	J:157504
	decreased vasodilation	J:157504
	delayed wound healing	J:157504
	impaired macrophage phagocytosis	J:157504
	increased granulocyte number	J:157504
	increased neutrophil cell number	J:157504
	increased susceptibility to parasitic infection	J:157504
	increased systemic arterial blood pressure	J:157504
Ier3^tm1Mxw/Ier3^tm1Mxw involves: C57BL/6	abnormal intestine physiology	J:194587
	abnormal physiological response to xenobiotic	J:194587
	decreased incidence of tumors by chemical induction	J:194587
	decreased susceptibility to induced colitis	J:194587
	increased T-helper 17 cell number	J:194587
Ier3^tm1Raku/Ier3^tm1Raku involves: 129S6/SvEvTac	decreased heart left ventricle muscle contractility	J:131099
	heart left ventricle hypertrophy	J:131099
	increased heart rate	J:131099
	increased myocardial fiber size	J:131099
	increased systemic arterial blood pressure	J:131099

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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