Hes1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hes1
hes family bHLH transcription factor 1
MGI:104853

62 phenotypes from 6 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Alb^{tm1(cre/ERT2)Mtz}/Alb⁺ Hes1^tm1Kag/Hes1^tm1Kag involves: 129S2/SvPas * C57BL/6 * CBA	normal neoplasm	J:192740
Emx1^tm1(cre)Ito/Emx1⁺ Hes1^tm1Kag/Hes1^tm1Kag involves: 129P2/OlaHsd * C57BL/6 * CBA	normal nervous system phenotype	J:139170
Hes1^{tm1(cre/ERT2)Lcm}/Hes1⁺ involves: 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:169830
Hes1^{tm1(cre/ERT2)Lcm}/Hes1^{tm1(cre/ERT2)Lcm} involves: 129S1/Sv * 129X1/SvJ	embryonic lethality during organogenesis, complete penetrance	J:169830
Hes1^tm1.1Frad/Hes1^tm1.1Frad Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * DBA/2	normal immune system phenotype	J:167000
Hes1^tm1.1Frad/Hes1^tm1.1Frad Tg(Lck-cre)1Cwi/0 involves: C57BL/6	normal immune system phenotype	J:167000
Hes1^tm1.1Frad/Hes1^tm1.1Frad Tg(Mx1-cre)1Cgn/0 involves: C57BL/6 * CBA	abnormal T cell differentiation	J:167000
	decreased DN1 thymic pro-T cell number	J:167000
	decreased DN2 thymocyte number	J:167000
	decreased DN3 thymocyte number	J:167000
	decreased DN4 thymocyte number	J:167000
	decreased double-positive T cell number	J:167000
	decreased gamma-delta T cell number	J:167000
	normal hematopoietic system phenotype	J:167000
	increased DN1 thymic pro-T cell number	J:167000
	increased immature B cell number	J:167000
	thymus hypoplasia	J:167000
Hes1^tm1Fgu/Hes1⁺ involves: 129S1/Sv * 129X1/SvJ * CD-1	increased number of pulmonary neuroendocrine bodies	J:64088
Hes1^tm1Fgu/Hes1⁺ involves: 129S1/Sv * 129X1/SvJ * CD-1	increased solitary pulmonary neuroendocrine cell number	J:64088
Hes1^tm1Fgu/Hes1^tm1Fgu involves: 129S1/Sv * 129X1/SvJ	abnormal bile duct development	J:151981
	abnormal bile duct morphology	J:151981
	abnormal cell differentiation	J:203419
	abnormal common bile duct morphology	J:151981
	abnormal extrahepatic bile duct morphology	J:151981
	abnormal pancreas development	J:151981
	abnormal pituitary gland development	J:121843
	pituitary gland hypoplasia	J:121843
Hes1^tm1Fgu/Hes1^tm1Fgu involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal bile duct development	J:87397
	abnormal brain development	J:30431
	abnormal cochlear hair cell morphology	J:64679
	abnormal cystic duct morphology	J:87397
	abnormal exocrine pancreas morphology	J:59312
	abnormal inner ear vestibule morphology	J:70081
	abnormal intestine morphology	J:59312
	abnormal nasal placode morphology	J:62024
	abnormal neural tube morphology	J:30431, J:71074
	abnormal neuron differentiation	J:30431
	abnormal pancreas development	J:59312
	abnormal pancreas morphology	J:59312, J:87397
	abnormal retina neuronal layer morphology	J:54662
	abnormal stomach morphology	J:59312
	abnormal utricle morphology	J:70081
	abnormal vestibular saccule morphology	J:70081
	absent gallbladder	J:87397
	anencephaly	J:30431
	decreased body length	J:64088
	decreased club cell number	J:64088
	decreased embryo size	J:71074
	disorganized retina layers	J:54662
	embryonic lethality during organogenesis, incomplete penetrance	J:30431
	everted embryonic neuroepithelium	J:30431
	exencephaly	J:30431
	incomplete rostral neuropore closure	J:30431
	increased cochlear inner hair cell number	J:64679, J:70081
	increased cochlear outer hair cell number	J:64679, J:70081
	increased number of pulmonary neuroendocrine bodies	J:64088
	increased solitary pulmonary neuroendocrine cell number	J:64088
	increased vestibular hair cell number	J:64679, J:70081
	kinked neural tube	J:30431
	lethality throughout fetal growth and development, incomplete penetrance	J:30431
	microcephaly	J:30431
	perinatal lethality, complete penetrance	J:30431
	small lung	J:64088
	small stomach	J:59312
Hes1^tm1Kag/Hes1^tm1Kag Foxa2^{tm3.1(icre)Heli}/Foxa2⁺ involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal pancreas development	J:184814
	abnormal pancreatic beta cell differentiation	J:184814
Hes1^tm2.1Kag/Hes1^tm2.1Kag involves: C57BL/6NCrlj * CBA/JNCrlj	normal nervous system phenotype	J:203419
Tg(Dct-Hes1)#Nshk/0 Not Specified	decreased melanoblast apoptosis	J:111228
Tg(Dct-Hes1)#Nshk/0 Not Specified	normal pigmentation phenotype	J:111228

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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