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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rorc
RAR-related orphan receptor gamma
MGI:104856
66 phenotypes from 8 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Rorcm1Btlr/Rorcm1Btlr
C57BL/6J-Rorcm1Btlr 		decreased CD4-positive, alpha-beta T cell number J:203039
decreased CD8-positive, alpha-beta T cell number J:203039
Rorcm2Btlr/Rorcm2Btlr
C57BL/6J-Rorcm2Btlr 		decreased IgM level J:217792
decreased response to antigen J:217792
impaired humoral immune response J:217792
Rorcm3Btlr/Rorcm3Btlr
C57BL/6J-Rorcm3Btlr 		abnormal CD4-positive, alpha beta T cell morphology J:234257
decreased B-2 B cell number J:234257
decreased CD4-positive, alpha-beta T cell number J:234257
decreased CD8-positive, naive alpha-beta T cell number J:234257
decreased IgG level J:234257
decreased IgM level J:234257
decreased response to antigen J:234257
impaired humoral immune response J:234257
increased B-1a cell number J:234257
increased B-1b cell number J:234257
increased CD8-positive, alpha-beta T cell number J:234257
increased effector memory CD4-positive, alpha-beta T cell number J:234257
increased effector memory CD8-positive, alpha-beta T cell number J:234257
Rorctm1.1Zsun/Rorctm1.1Zsun
B6(129S4)-Rorctm1.1Zsun 		abnormal T-helper 17 cell differentiation J:248565
absent Peyer's patches J:248565
decreased susceptibility to experimental autoimmune encephalomyelitis J:248565
small inguinal lymph nodes J:248565
Rorctm1Amj/Rorctm1Amj
either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * DBA/2) 		abnormal interleukin level J:123351
abnormal lymph organ development J:64381
abnormal splenic cell ratio J:64381
abnormal T cell physiology J:64381
absent lymph nodes J:64381
absent Peyer's patches J:64381
decreased CD4-positive, alpha-beta T cell number J:64381
decreased CD8-positive, alpha-beta T cell number J:64381
decreased double-positive T cell number J:64381
decreased T cell number J:64381
decreased thymus weight J:64381
enlarged spleen J:64381
increased double-negative T cell number J:64381
increased T cell apoptosis J:64381
thymus hypoplasia J:64381
Rorctm1Litt/Rorctm1Litt
involves: 129P2/OlaHsd 		abnormal CD8-positive, alpha-beta T cell differentiation J:248565
abnormal cell cycle J:248565
abnormal colon morphology J:158663
abnormal T cell differentiation J:128344, J:248565
abnormal T cell morphology J:248565
abnormal T-helper 17 cell differentiation J:248565
absent lymph nodes J:248565
colitis J:158663
colonic necrosis J:158663
decreased CD4-positive, alpha-beta T cell number J:248565
decreased double-positive T cell number J:248565
decreased susceptibility to experimental autoimmune encephalomyelitis J:248565
decreased thymocyte number J:248565
increased susceptibility to bacterial infection J:158663
increased susceptibility to bacterial infection induced morbidity/mortality J:158663
increased thymocyte apoptosis J:248565
weight loss J:158663
Rorctm2Litt/Rorctm2Litt
involves: 129P2/OlaHsd 		abnormal CD4-positive, alpha-beta intraepithelial T cell morphology J:91566
abnormal CD8 positive, alpha-beta intraepithelial T cell morphology J:91566
abnormal gut-associated lymphoid tissue morphology J:87395, J:91566
abnormal lymph organ development J:87395
absent lymph nodes J:87395
absent Peyer's patches J:87395
decreased double-negative T cell number J:91566
decreased double-positive T cell number J:87395
decreased NK cell number J:142654
increased thymocyte apoptosis J:87395
Tg(CD2-Rorc)#Staka/0
involves: C57BL/6 		abnormal CD4-positive, alpha beta T cell morphology J:236222
abnormal salivary gland physiology J:230700
abnormal susceptibility to Picornaviridae infection J:236222
abnormal T-helper 17 cell physiology J:236222
normal behavior/neurological phenotype J:236222
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:230700
decreased CD8-positive, alpha-beta T cell number J:236222
decreased IgG2c level J:236222
decreased IgG3 level J:236222
decreased IgG level J:236222
decreased interferon-gamma secretion J:236222
decreased interleukin-10 secretion J:236222
decreased salivation J:230700
demyelination J:236222
increased anti-nuclear antigen antibody level J:230700
increased autoantibody level J:230700
increased effector memory CD4-positive, alpha-beta T cell number J:230700
increased interferon-gamma secretion J:236222
increased interleukin-17 secretion J:236222
increased susceptibility to autoimmune disorder J:230700
lacrimal gland inflammation J:230700
lung inflammation J:230700
salivary gland inflammation J:230700
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory