Akt2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Akt2
thymoma viral proto-oncogene 2
MGI:104874

29 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Akt2^tm1.1Mbb/Akt2^tm1.1Mbb B6.129P2-Akt2^tm1.1Mbb	decreased circulating glucose level	J:155432
	decreased liver triglyceride level	J:155432
	decreased susceptibility to diet-induced obesity	J:155432
	increased circulating insulin level	J:155432
Akt2^tm1.1Mbb/Akt2^tm1.1Mbb involves: 129P2/OlaHsd	decreased liver triglyceride level	J:160759
	hyperglycemia	J:160759
	normal immune system phenotype	J:135903
	impaired glucose tolerance	J:160759
Akt2^tm1.1Mbb/Akt2^tm1.1Mbb involves: 129P2/OlaHsd * C57BL/6	decreased adipocyte glucose uptake	J:71491
	decreased skeletal muscle cell glucose uptake	J:71491
	hyperglycemia	J:71491
	impaired glucose tolerance	J:71491
	increased circulating insulin level	J:71491
	increased pancreatic islet number	J:71491
	insulin resistance	J:71491
Akt2^tm1.2Mbb/Akt2^tm1.2Mbb Tg(Alb1-cre)1Khk/0 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL	decreased liver triglyceride level	J:155432
	normal growth/size/body region phenotype	J:155432
Akt2^tm1Hem/Akt2^tm1Hem involves: 129P2/OlaHsd	abnormal ovary morphology	J:185012
	decreased corpora lutea number	J:185012
	increased circulating testosterone level	J:185012
	increased theca cell number	J:185012
	ovary cyst	J:185012
Akt2^tm1Hem/Akt2^tm1Hem involves: 129P2/OlaHsd * C57BL/6	hyperglycemia	J:114675
	impaired glucose tolerance	J:114675
	increased circulating insulin level	J:114675
	insulin resistance	J:114675
Akt2^tm1Rsg/Akt2^tm1Rsg DBA/1LacJ-Akt2^tm1Rsg	abnormal glucose homeostasis	J:84606
	decreased body length	J:84606
	decreased body weight	J:84606
	decreased brown adipose tissue mass	J:84606
	decreased circulating insulin level	J:84606
	decreased pancreatic beta cell number	J:84606
	decreased white adipose tissue mass	J:84606
	hyperglycemia	J:84606
	impaired glucose tolerance	J:84606
	increased circulating insulin level	J:84606
	insulin resistance	J:84606
Akt2^tm1Rsg/Akt2^tm1Rsg involves: C57BL/6 * DBA/1LacJ	decreased circulating leptin level	J:149156
	enlarged pancreatic islets	J:149156
	impaired glucose tolerance	J:149156
	increased circulating insulin level	J:149156
	insulin resistance	J:149156
Tg(Lck-Akt2*)#Test/0 Not Specified	increased lymphoma incidence	J:154583
	increased T cell derived lymphoma incidence	J:153923
	premature death	J:153923, J:154583

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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