Akt2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Akt2
thymoma viral proto-oncogene 2
MGI:104874

46 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Akt1^tm1Hem/Akt1⁺ Akt2^tm1Hem/Akt2^tm1Hem Akt3^tm1Hem/Akt3^tm1Hem involves: 129P2/OlaHsd * C57BL/6	decreased body size	J:114675
	decreased body weight	J:114675
Akt1^tm1Hem/Akt1^tm1Hem Akt2^tm1Hem/Akt2^tm1Hem Akt3^tm1Hem/Akt3^tm1Hem involves: 129P2/OlaHsd * C57BL/6	prenatal lethality, complete penetrance	J:114675
Akt1^tm1Nhy/Akt1⁺ Akt2^tm1Rsg/Akt2^tm1Rsg involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ	decreased circulating leptin level	J:149156
	decreased insulin secretion	J:149156
	decreased pancreatic beta cell number	J:149156
	decreased percent body fat/body weight	J:149156
	decreased white adipose tissue amount	J:149156
	enlarged pancreatic islets	J:149156
	hyperglycemia	J:149156
	impaired glucose tolerance	J:149156
	increased circulating insulin level	J:149156
Akt1^tm1Nhy/Akt1⁺ Akt2^tm1Rsg/Akt2^tm1Rsg Akt3^tm1Nhy/Akt3^tm1Nhy involves: 129/Sv * C57BL/6 * DBA/1LacJ	hyperglycemia	J:149156
Akt1^tm1Nhy/Akt1⁺ Akt2^tm1Rsg/Akt2^tm1Rsg Pten^tm1Ppp/Pten⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ	enlarged pancreatic islets	J:149156
	impaired glucose tolerance	J:149156
	increased circulating insulin level	J:149156
Akt1^tm1Nhy/Akt1^tm1Nhy Akt2^tm1Rsg/Akt2^tm1Rsg involves: 129/Sv * C57BL/6 * DBA/1LacJ	abnormal keratinocyte morphology	J:83741
	abnormal lipid homeostasis	J:83741
	decreased birth weight	J:83741
	decreased fetal weight	J:83741
	decreased hair follicle number	J:83741
	delayed bone ossification	J:83741
	muscle hypoplasia	J:83741
	perinatal lethality	J:83741
	respiratory distress	J:83741
	thin epidermis stratum spinosum	J:83741
	thin skin	J:83741
	translucent skin	J:83741
	underdeveloped hair follicles	J:83741
Akt1^tm1Pnt/Akt1^tm1Pnt Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Akt3^tm1Mbb/Akt3^tm1Mbb Tg(Lck-cre)1Cwi/0 involves: 129P2/OlaHsd	arrested T cell differentiation	J:135903
	decreased double-positive T cell number	J:135903
	increased double-negative T cell number	J:135903
	increased T cell apoptosis	J:135903
	thymus hypoplasia	J:135903
Akt1^tm1Pnt/Akt1^tm1Pnt Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Tg(Lck-cre)1Cwi/0 involves: 129P2/OlaHsd	arrested T cell differentiation	J:135903
	decreased double-positive T cell number	J:135903
	increased double-negative T cell number	J:135903
	increased T cell apoptosis	J:135903
	thymus hypoplasia	J:135903
Akt2^tm1.1Mbb/Akt2⁺ Lep^ob/Lep^ob B6.Cg-Lep^ob Akt2^tm1.1Mbb	decreased body weight	J:155432
	decreased liver triglyceride level	J:155432
	decreased liver weight	J:155432
Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Akt3^tm1Mbb/Akt3^tm1Mbb involves: 129P2/OlaHsd	no abnormal phenotype detected	J:135903
Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Lep^ob/Lep^ob B6.Cg-Lep^ob Akt2^tm1.1Mbb	abnormal lipid homeostasis	J:155432
	decreased body weight	J:155432
	decreased circulating cholesterol level	J:155432
	decreased liver triglyceride level	J:155432
	decreased liver weight	J:155432
	increased circulating glucose level	J:155432
	increased circulating insulin level	J:155432
Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Pten^tm1Hwu/Pten^tm1Hwu Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA	abnormal liver morphology	J:218587
	decreased susceptibility to hepatic steatosis	J:218587
	hyperglycemia	J:160759
	impaired glucose tolerance	J:160759
	increased tumor latency	J:218587
	normal liver/biliary system phenotype	J:160759
Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul involves: 129 * C57BL/6 * FVB/N	increased mammary adenocarcinoma incidence	J:117336
Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Tg(MMTV-PyVT)634Mul/0 involves: 129 * C57BL/6 * FVB/N	increased mammary adenocarcinoma incidence	J:117336
Akt2^tm1.2Mbb/Akt2^tm1.2Mbb Lep^ob/Lep^ob Tg(Alb1-cre)1Khk/0 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL	abnormal lipid homeostasis	J:155432
	decreased body weight	J:155432
	decreased liver triglyceride level	J:155432
	decreased liver weight	J:155432
	increased circulating glucose level	J:155432
Akt2^tm1Hem/Akt2^tm1Hem Akt3^tm1Hem/Akt3^tm1Hem involves: 129P2/OlaHsd * C57BL/6	abnormal testis morphology	J:114675
	decreased body size	J:114675
	decreased body weight	J:114675
	decreased brain weight	J:114675
	decreased circulating testosterone level	J:114675
	decreased testis weight	J:114675
	hyperglycemia	J:114675
	impaired glucose tolerance	J:114675
	increased circulating insulin level	J:114675
	insulin resistance	J:114675
Akt2^tm1Rsg/Akt2^tm1Rsg Akt3^tm1Nhy/Akt3^tm1Nhy involves: 129/Sv * C57BL/6 * DBA/1LacJ	impaired glucose tolerance	J:149156
Akt2^tm1Rsg/Akt2^tm1Rsg Pten^tm1Ppp/Pten⁺ involves: 129S1/Sv * C57BL/6 * DBA/1LacJ	decreased circulating insulin level	J:149156
	impaired glucose tolerance	J:149156

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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