Hes5 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hes5
hes family bHLH transcription factor 5
MGI:104876

33 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Emx1^tm1(cre)Ito/Emx1⁺ Hes1^tm1Fgu/Hes1^tm1Hojo Hes5^tm1Fgu/Hes5^tm1Fgu involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	abnormal neurohypophysis morphology	J:121843
	abnormal pituitary diverticulum morphology	J:121843
	abnormal pituitary gland development	J:121843
	abnormal pituitary gland morphology	J:121843
	abnormal pituitary infundibular stalk morphology	J:121843
	absent pituitary intermediate lobe	J:121843
	increased somatotroph cell number	J:121843
	pituitary gland hypoplasia	J:121843
Emx1^tm1(cre)Ito/Emx1⁺ Hes1^tm1Kag/Hes1^tm1Kag Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	abnormal brain morphology	J:139170
	abnormal embryonic neuroepithelium morphology	J:139170
	abnormal neuron differentiation	J:139170
	absent choroid plexus	J:139170
	increased Cajal-Retzius cell number	J:139170
Hes1^tm1Fgu/Hes1⁺ Hes5^tm1Fgu/Hes5^tm1Fgu involves: 129S1/Sv * 129X1/SvJ * CD-1	increased cochlear outer hair cell number	J:70081
Hes1^tm1Fgu/Hes1^tm1Fgu Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu involves: 129S1/Sv * 129X1/SvJ * CD-1	premature neuronal precursor differentiation	J:94391
Hes1^tm1Fgu/Hes1^tm1Fgu Hes5^tm1Fgu/Hes5⁺ involves: 129S1/Sv * 129X1/SvJ * CD-1	increased cochlear inner hair cell number	J:70081
Hes1^tm1Fgu/Hes1^tm1Fgu Hes5^tm1Fgu/Hes5^tm1Fgu involves: 129S1/Sv * 129X1/SvJ	abnormal choroid plexus morphology	J:139170
Hes1^tm1Fgu/Hes1^tm1Fgu Hes5^tm1Fgu/Hes5^tm1Fgu involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal astrocyte morphology	J:94391
	abnormal brain development	J:94391
	abnormal CNS glial cell morphology	J:94391
	abnormal dorsal root ganglion morphology	J:94391
	abnormal embryonic/fetal subventricular zone morphology	J:94391
	abnormal ependyma morphology	J:94391
	abnormal forebrain morphology	J:94391
	abnormal nasal placode morphology	J:62024
	abnormal neural tube morphology	J:62024, J:94391
	abnormal spinal cord morphology	J:94391
	absent oligodendrocytes	J:94391
	absent optic vesicle	J:94391
	decreased embryo size	J:54662
	embryonic lethality during organogenesis, incomplete penetrance	J:94391
	neuron hypertrophy	J:54662
	premature neuronal precursor differentiation	J:94391
Hes1^tm1Kag/Hes1^tm1Kag Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu Tg(Nes-cre/ERT2)5-1Imayo/0 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	normal nervous system phenotype	J:139170

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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