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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prkar1a
protein kinase, cAMP dependent regulatory, type I, alpha
MGI:104878
95 phenotypes from 6 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Prkar1atm1.1Geno/Prkar1a+
involves: C57BL/6J 		abnormal craniofacial bone morphology J:303060
abnormal craniofacial morphology J:303060
abnormal long bone diaphysis morphology J:303060
abnormal long bone epiphyseal plate morphology J:303060
abnormal long bone epiphyseal plate proliferative zone J:303060
abnormal long bone metaphysis morphology J:303060
abnormal skeleton development J:303060
abnormal trabecular bone morphology J:303060
abnormal urine homeostasis J:303060
brachydactyly J:303060
chondrodystrophy J:303060
decreased body length J:303060
decreased bone mineral density J:303060
decreased bone volume J:303060
decreased length of long bones J:303060
decreased width of hypertrophic chondrocyte zone J:303060
delayed endochondral bone ossification J:303060
female infertility J:303060
increased circulating parathyroid hormone level J:303060
postnatal growth retardation J:303060
short limbs J:303060
short snout J:303060
short tail J:303060
Prkar1atm1.1Geno/Prkar1atm1.1Geno
involves: C57BL/6J 		prenatal lethality, complete penetrance J:303060
Prkar1atm1.1Lsk/Prkar1a+
either: (involves: 129S1/Sv * 129X1/SvJ * C3H) or (involves: 129S1/Sv * 129X1/SvJ * A/J) 		infertility J:98799
Prkar1atm1.1Lsk/Prkar1a+
involves: 129S1/Sv * 129X1/SvJ 		increased thyroid tumor incidence J:98799
increased tumor incidence J:98799
Prkar1atm1.1Lsk/Prkar1a+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal bone mineralization J:160299
decreased bone mineral density J:160299
increased osteosarcoma incidence J:160299
increased Schwannoma incidence J:160299
increased skeletal tumor incidence J:160299
increased thyroid tumor incidence J:160299
Prkar1atm1.1Lsk/Prkar1atm1.1Lsk
involves: 129S1/Sv * 129X1/SvJ 		embryonic lethality during organogenesis, complete penetrance J:98799
Prkar1atm1.2Lsk/Prkar1a+
Tg(Col1a1-cre)1Kry/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal bone remodeling J:165282
increased skeletal tumor incidence J:165282
Prkar1atm1.2Lsk/Prkar1atm1.2Lsk
Tg(Col1a1-cre)1Kry/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		neonatal lethality, complete penetrance J:165282
Prkar1atm1.2Lsk/Prkar1atm1.2Lsk
Tg(Ghrhr-cre)3242Lsk/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		increased circulating growth hormone level J:130264
increased pituitary gland tumor incidence J:130264
Prkar1atm1.2Lsk/Prkar1atm1.2Lsk
Tg(TPO-cre)1Shk/0
involves: 129S1/Sv * 129X1/SvJ * FVB/NCr 		abnormal thyroid gland morphology J:241066
decreased thyroid-stimulating hormone level J:241066
enlarged thyroid gland J:241066
increased activity of thyroid gland J:241066
increased thyroid carcinoma incidence J:225245, J:241066
increased thyroxine level J:241066
Prkar1atm1.2Lsk/Prkar1atm1.2Lsk
Tg(Tyr-cre)3Gfk/0
either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) 		increased facial tumor incidence J:98799
increased Schwannoma incidence J:98799
Prkar1atm1Gsm/Prkar1a+
involves: 129X1/SvJ 		decreased heart rate variability J:93393
increased fibrosarcoma incidence J:93393
increased hemangiosarcoma incidence J:93393
increased hepatocellular carcinoma incidence J:93393
increased sarcoma incidence J:93393
increased tumor incidence J:93393
normal pigmentation phenotype J:93393
reduced male fertility J:93393
Prkar1atm1Gsm/Prkar1atm1Gsm
involves: 129X1/SvJ * C57BL/6 		abnormal cardiogenic plate morphology J:78010
abnormal cell morphology J:78010
abnormal developmental patterning J:78010
abnormal embryo size J:78010
abnormal embryonic tissue morphology J:78010
abnormal foregut morphology J:78010
abnormal primitive streak morphology J:78010
abnormal somite shape J:78010
absent heart tube J:78010
decreased axial mesoderm size J:78010
decreased embryo size J:78010
decreased paraxial mesoderm size J:78010
decreased somite size J:78010
embryonic growth retardation J:78010
embryonic lethality during organogenesis, complete penetrance J:78010
enhanced wound healing J:78010
excessive folding of visceral yolk sac J:78010
failure of initiation of embryo turning J:78010
Prkar1atm1Lsk/Prkar1atm1Lsk
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:98799
Prkar1atm1Lsk/Prkar1atm1Lsk
Tg(Akr1b7-cre)1Anm/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal adipose tissue distribution J:161521
abnormal adrenal cortex morphology J:161521
abnormal adrenal gland physiology J:161521
abnormal adrenal gland zona glomerulosa morphology J:161521
adrenal cortical hyperplasia J:161521
decreased adrenal gland zona fasciculata size J:161521
decreased physiological sensitivity to xenobiotic J:161521
disorganized adrenal gland zona fasciculata J:161521
increased adrenal gland apoptosis J:161521
increased circulating corticosterone level J:161521
retention of the adrenal gland x-zone J:161521
Prkar1atm2Gsm/Prkar1atm2Gsm
Tg(Cr2-cre)3Cgn/0
involves: 129X1/SvJ * C57BL/6 		abnormal class switch recombination J:147785
Prkar1atm2Gsm/Prkar1atm2Gsm
Tg(Plp1-cre)1Bzal/0
involves: 129X1/SvJ * C57BL/6 * C57BL/6N * DBA/2 		abnormal nose morphology J:148464
abnormal small intestinal transit time J:148464
abnormal small intestine morphology J:148464
blepharoptosis J:148464
decreased body weight J:148464
decreased white adipose tissue amount J:148464
distended abdomen J:148464
dry eyes J:148464
muscular atrophy J:148464
premature death J:148464
short snout J:148464
Prkar1atm2Gsm/Prkar1atm2Gsm
Tlx2tm1.1(cre)Rpk/Tlx2+
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/6N * DBA/2 		abnormal small intestinal transit time J:148464
normal craniofacial phenotype J:148464
normal digestive/alimentary phenotype J:148464
distended duodenum J:148464
intestinal hypoperistalsis J:148464
intestinal obstruction J:148464
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12/17/2024
MGI 6.24 		The Jackson Laboratory