About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prkar1a
protein kinase, cAMP dependent regulatory, type I, alpha
MGI:104878
22 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Prkacatm1Gsm/Prkaca+
Prkar1atm1.1Lsk/Prkar1a+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal bone mineralization J:160299
abnormal compact bone morphology J:160299
abnormal periosteum morphology J:160299
decreased bone mineral density J:160299
increased osteochondroma incidence J:160299
increased osteosarcoma incidence J:160299
increased skeletal tumor incidence J:160299, J:166728
normal neoplasm J:160299
Prkacatm1Gsm/Prkacatm1Gsm
Prkar1atm1Gsm/Prkar1atm1Gsm
involves: 129X1/SvJ * C57BL/6 		pericardial edema J:78010
Prkar1atm1.2Lsk/Prkar1a+
Rb1tm2Brn/Rb1+
Tg(Col1a1-cre)1Kry/0
Trp53tm1Brn/Trp53tm1Brn
involves: 129 * 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N 		increased cell migration J:234128
increased osteosarcoma incidence J:234128
premature death J:234128
Prkar1atm1.2Lsk/Prkar1a+
Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(Col1a1-cre)1Kry/0
involves: 129 * 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N 		increased osteosarcoma incidence J:234128
premature death J:234128
Prkar1atm1.2Lsk/Prkar1a+
Tg(Col1a1-cre)1Kry/0
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N 		increased osteosarcoma incidence J:234128
premature death J:234128
Prkar1atm1.2Lsk/Prkar1a+
Ptentm1.1Mwst/Pten+
Tg(TPO-cre)1Shk/0
involves: 129S1/Sv * 129X1/SvJ * FVB/NCr 		decreased survivor rate J:225245
normal neoplasm J:225245
Prkar1atm1.2Lsk/Prkar1a+
Tg(Bglap2-TAg)1Rkho/0
Tg(Col1a1-cre)1Kry/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal motor capabilities/coordination/movement J:165282
increased osteosarcoma incidence J:165282
paralysis J:165282
premature death J:165282
Prkar1atm1.2Lsk/Prkar1atm1.2Lsk
Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(TPO-cre)1Shk/0
involves: 129S1/Sv * 129X1/SvJ * FVB/NCr 		decreased abdominal adipose tissue amount J:225245
decreased subcutaneous adipose tissue amount J:225245
enlarged thyroid gland J:225245
increased activity of thyroid gland J:225245
increased circulating thyroxine level J:225245
increased metastatic potential J:225245
increased thyroid carcinoma incidence J:225245
premature death J:225245
weight loss J:225245
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory