Pdcd1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pdcd1
programmed cell death 1
MGI:104879

47 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Btla^tm1Kmm/Btla^tm1Kmm Pdcd1^tm1Hon/Pdcd1^tm1Hon B6.129S-Pdcd1^tm1Hon Btla^tm1Kmm	decreased length of allograft survival	J:119356
	increased T cell proliferation	J:119356
Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Pdcd1^tm1Hon/Pdcd1^tm1Hon involves: 129S2/SvPas * 129S4/SvJae * BALB/c	abnormal cytokine level	J:207275
	abnormal urinary bladder urothelium morphology	J:207275
	abnormal urine cytokine level	J:207275
	decreased body weight	J:207275
	increased autoantibody level	J:207275
	oliguria	J:207275
	urinary bladder inflammation	J:207275
Foxp3^{tm2.1(EGFP/cre)Shori}/Foxp3^{tm2.1(EGFP/cre)Shori} Pdcd1^tm1Hon/Pdcd1^tm1Hon involves: 129 * 129S2/SvPas * C57BL/6	premature death	J:234397
Foxp3^{tm2.1(EGFP/cre)Shori}/Y Pdcd1^tm1Hon/Pdcd1^tm1Hon involves: 129 * 129S2/SvPas * C57BL/6	decreased circulating lipase level	J:234397
	enlarged lymph nodes	J:234397
	enlarged spleen	J:234397
	increased effector memory T-helper cell number	J:234397
	increased susceptibility to autoimmune disorder	J:234397
	lymph node hyperplasia	J:234397
	pancreas atrophy	J:234397
	pancreas inflammation	J:234397
	premature death	J:234397
	spleen hyperplasia	J:234397
Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux Tg(MMTV-PyVT)634Mul/0 involves: C57BL/6 * FVB/N	decreased interleukin-17 secretion	J:190150
	decreased regulatory T cell number	J:190150
	decreased T-helper 2 cell number	J:190150
	decreased T-helper 17 cell number	J:190150
	decreased tumor growth/size	J:190150
	extended life span	J:190150
	increased apoptosis	J:190150
	increased interferon-gamma secretion	J:190150
	increased interleukin-2 secretion	J:190150
	increased T-helper 1 cell number	J:190150
	increased tumor latency	J:190150
	increased tumor necrosis factor secretion	J:190150
Pdcd1^tm1.1Shr/Pdcd1^tm1.1Shr Tg(TcraTcrb)1100Mjb/0 involves: C57BL/6	abnormal immune tolerance	J:153040
	decreased T cell proliferation	J:153040
	increased susceptibility to autoimmune diabetes	J:153040
	increased T cell proliferation	J:153040
	insulitis	J:153040
	pancreas inflammation	J:153040
	vascular inflammation	J:153040
Pdcd1^tm1Hon/Pdcd1^tm1Hon Tg(Tcra2D2,Tcrb2D2)1Kuch/0 involves: 129S2/SvPas	decreased susceptibility to experimental autoimmune encephalomyelitis	J:140751
Pdcd1^tm1Hon/Pdcd1^tm1Hon Vsir^tm1Lex/Vsir^tm1Lex involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6	abnormal T cell activation	J:222944
	hepatic necrosis	J:222944
	normal immune system phenotype	J:222944
	increased IgA level	J:222944
	increased IgM level	J:222944
	increased inflammatory response	J:222944
	increased interferon-gamma secretion	J:222944
	increased interleukin-17 secretion	J:222944
	increased tumor necrosis factor secretion	J:222944
	pancreas necrosis	J:222944
	pulmonary necrosis	J:222944
Pdcd1^tm1Hon/Pdcd1^tm1Hon Vsir^tm1Lex/Vsir^tm1Lex Tg(Tcra2D2,Tcrb2D2)1Kuch/0 involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6	increased susceptibility to experimental autoimmune encephalomyelitis	J:222944

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24