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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gpx1
glutathione peroxidase 1
MGI:104887
41 phenotypes from 6 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gpx1tm1.1(KOMP)Vlcg/Gpx1tm1.1(KOMP)Vlcg
C57BL/6N-Gpx1tm1.1(KOMP)Vlcg/Ucd 		abnormal epididymis morphology J:211773
abnormal testis morphology J:211773
decreased body length J:211773
enlarged epididymis J:211773
small testis J:211773
Gpx1tm1Kola/Gpx1tm1Kola
B6.129S2(CF1)-Gpx1tm1Kola 		normal immune system phenotype J:100436
Gpx1tm1Kola/Gpx1tm1Kola
involves: 129S2/SvPas * BALB/c * CF-1 		abnormal response to injury J:79183
brain ischemia J:71798
increased cerebral infarct size J:71798
increased inflammatory response J:79183
increased neuron apoptosis J:71798, J:79183
increased susceptibility to ischemic brain injury J:71798
oxidative stress J:71798
Gpx1tm1Kola/Gpx1tm1Kola
involves: 129S2/SvPas * CF-1 		abnormal cell cycle J:87985
abnormal cell morphology J:87985
cellular necrosis J:87985
decreased cell proliferation J:87985
increased cellular sensitivity to hydrogen peroxide J:87985
increased cellular sensitivity to oxidative stress J:49644, J:87985
normal mortality/aging J:49644
Gpx1tm1Mgr/Gpx1tm1Mgr
involves: 129 * C57BL/6J 		abnormal lipid level J:62395
abnormal mitochondrial physiology J:62395
decreased body weight J:62395
Gpx1tm1Ysh/Gpx1+
involves: 129S1/Sv * 129X1/SvJ 		abnormal enzyme/coenzyme activity J:110762
Gpx1tm1Ysh/Gpx1tm1Ysh
B6.129-Gpx1tm1Ysh 		abnormal jejunum crypts of Lieberkuhn morphology J:63988
decreased cellular sensitivity to gamma-irradiation J:63988
Gpx1tm1Ysh/Gpx1tm1Ysh
involves: 129S1/Sv * 129X1/SvJ 		abnormal catalase activity J:110762
cataract J:142446
decreased glutathione peroxidase activity J:110762
Gpx1tm1Ysh/Gpx1tm1Ysh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal ileum crypts of Lieberkuhn morphology J:63988
abnormal jejunum crypts of Lieberkuhn morphology J:63988
abnormal platelet physiology J:41169
cochlear ganglion degeneration J:113167
cochlear inner hair cell degeneration J:113167
cochlear outer hair cell degeneration J:113167
decreased cellular sensitivity to gamma-irradiation J:63988
increased or absent threshold for auditory brainstem response J:113167
increased susceptibility to noise-induced hearing loss J:113167
Tg(Gpx1)41Dkd/0
involves: C3H * C57BL/6 		abnormal cardiovascular system physiology J:127782
decreased myocardial infarct size J:127782
increased cardiac muscle contractility J:127782
myocardium necrosis J:89952, J:127782
Tg(Gpx1)41Spec/0
involves: C3H * C57BL/6 		increased glutathione peroxidase activity J:110762
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory