Tpt1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tpt1
tumor protein, translationally-controlled 1
MGI:104890

19 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tpt1^tm1.1Atel/Tpt1^tm1.1Atel involves: C57BL/6	decreased cell proliferation	J:150991
	embryonic growth retardation	J:150991
	embryonic lethality, complete penetrance	J:150991
	increased embryonic tissue cell apoptosis	J:150991
Tpt1^tm1.1Yen/Tpt1^tm1.1Yen involves: 129 * C57BL/6	abnormal endoderm development	J:127458
	abnormal mesoderm development	J:127458
	abnormal primitive streak formation	J:127458
	decreased embryo size	J:127458
	decreased embryonic epiblast cell proliferation	J:127458
	embryonic lethality between somite formation and embryo turning, complete penetrance	J:127458
	failure of chorioallantoic fusion	J:127458
	increased embryonic epiblast cell apoptosis	J:127458
Tpt1^tm1Kefu/Tpt1⁺ either: 129S6/SvEvTac-Tpt1^tm1Kefu or B6.129S6-Tpt1^tm1Kefu	increased sensitivity to induced cell death	J:148696
Tpt1^tm1Kefu/Tpt1^tm1Kefu 129S6/SvEvTac-Tpt1^tm1Kefu	perinatal lethality, complete penetrance	J:148696
Tpt1^tm1Kefu/Tpt1^tm1Kefu B6.129S6-Tpt1^tm1Kefu	perinatal lethality, complete penetrance	J:148696
Tpt1^tm1Kefu/Tpt1^tm1Kefu either: 129S6/SvEvTac-Tpt1^tm1Kefu or B6.129S6-Tpt1^tm1Kefu	abnormal blastocyst morphology	J:148696
	embryonic lethality before implantation, incomplete penetrance	J:148696
	embryonic lethality between implantation and somite formation, complete penetrance	J:148696
Tpt1^tm1Kefu/Tpt1^tm1Kefu involves: 129S6/SvEvTac * C57BL/6	premature death	J:148696
Tpt1^tm1Yen/Tpt1^tm1Yen involves: 129 * C57BL/6	no abnormal phenotype detected	J:127458

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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