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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gpc3
glypican 3
MGI:104903
66 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gpc3Gt(Ex136)Byg/Y
involves: 129P2/OlaHsd * C57BL/6 		abnormal kidney medulla morphology J:64330
abnormal ventral body wall morphology J:64330
increased body size J:64330
kidney medulla cyst J:64330
perinatal lethality, incomplete penetrance J:64330
split xiphoid process J:64330
Gpc3Gt(Ex136)Byg/Gpc3+
involves: 129P2/OlaHsd * C57BL/6 		abnormal kidney medulla morphology J:64330
abnormal ventral body wall morphology J:64330
increased body size J:64330
kidney medulla cyst J:64330
split xiphoid process J:64330
Gpc3Gt(Ex136)Byg/Gpc3Gt(Ex136)Byg
involves: 129P2/OlaHsd * C57BL/6 		increased embryo size J:70273
kidney cyst J:70273
neonatal lethality, complete penetrance J:70273
Gpc3tm1Arge/Y
either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J) 		abnormal enzyme/coenzyme activity J:75054
abnormal intestine morphology J:75054
abnormal kidney medulla morphology J:75054
abnormal kidney morphology J:75054
absent mandible J:75054
asymmetric sternocostal joints J:75054
belly spot J:75054
decreased spleen weight J:75054
dilated renal tubule J:75054
distended abdomen J:75054
hydronephrosis J:75054
hypoglycemia J:75054
increased body weight J:75054
increased placenta weight J:75054
increased placental labyrinth size J:75054
increased spleen B cell follicle size J:75054
kidney cortex atrophy J:75054
kidney cortex cyst J:75054
kidney corticomedullary cyst J:75054
kidney cyst J:75054
kidney medulla cyst J:75054
polydactyly J:75054
postnatal growth retardation J:75054
postnatal lethality, incomplete penetrance J:75054
normal respiratory system phenotype J:75054
small spleen J:75054
white spotting J:75054
Gpc3tm1Arge/Gpc3+
either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J) 		belly spot J:75054
white spotting J:75054
Gpc3tm1Arge/Gpc3tm1Arge
either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J) 		belly spot J:75054
increased placenta weight J:75054
postnatal lethality, incomplete penetrance J:75054
normal respiratory system phenotype J:75054
white spotting J:75054
Gpc3tm1Fil/Y
B6.Cg-Gpc3tm1Fil 		abnormal branching involved in ureteric bud morphogenesis J:73877
abnormal kidney collecting duct morphology J:67732
abnormal kidney cortex morphology J:73877
abnormal kidney development J:73877
abnormal kidney medulla morphology J:67732, J:73877
abnormal kidney weight J:73877
abnormal ureteric bud morphology J:73877
enlarged kidney J:73877
normal homeostasis/metabolism phenotype J:73877
increased body weight J:73877
increased lung weight J:73877
increased susceptibility to bacterial infection J:73877
kidney cyst J:67732, J:73877
lung inflammation J:73877
mandible hypoplasia J:73877
postnatal lethality, complete penetrance J:73877
postnatal lethality, incomplete penetrance J:73877
rhinitis J:73877
Gpc3tm1Fil/Gpc3+
B6.Cg-Gpc3tm1Fil 		abnormal kidney development J:73877
abnormal ureteric bud morphology J:73877
impaired branching involved in ureteric bud morphogenesis J:73877
increased body weight J:73877
kidney cyst J:73877
Gpc3tm1Fil/?
involves: 129 * C57BL/6 		abnormal bone marrow cell morphology/development J:195867
abnormal hematopoietic stem cell physiology J:195867
decreased hematopoietic stem cell number J:195867
Gpc3tm1Fil/Gpc3tm1Fil
B6.Cg-Gpc3tm1Fil 		abnormal kidney development J:73877
abnormal perineum morphology J:73877
abnormal ureteric bud morphology J:73877
dilated uterus J:73877
impaired branching involved in ureteric bud morphogenesis J:73877
increased body weight J:73877
increased susceptibility to bacterial infection J:73877
kidney cyst J:73877
lung inflammation J:73877
mandible hypoplasia J:73877
postnatal lethality, incomplete penetrance J:73877
vagina atresia J:73877
Gpc3tm1Snd/Y
involves: 129X1/SvJ * C57BL/6 		abnormal coronary vessel morphology J:154375
abnormal endochondral bone ossification J:104555
abnormal kidney medulla morphology J:64330
abnormal osteoclast differentiation J:104555
abnormal ventral body wall morphology J:64330
common atrioventricular valve J:154375
complete atrioventricular septal defect J:154375
coronary fistula J:154375
double outlet right ventricle J:154375
increased body size J:64330
inlet ventricular septal defect J:154375
kidney cyst J:64330
patent ductus arteriosus J:154375
perimembraneous ventricular septal defect J:154375
perinatal lethality, incomplete penetrance J:64330
split xiphoid process J:64330
umbilical hernia J:64330
ventricular septal defect J:154375
Gpc3tm1Snd/Gpc3+
involves: 129X1/SvJ * C57BL/6 		abnormal kidney medulla morphology J:64330
abnormal ventral body wall morphology J:64330
increased body size J:64330
kidney cyst J:64330
split xiphoid process J:64330
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory