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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Npy1r
neuropeptide Y receptor Y1
MGI:104963
89 phenotypes from 7 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Npy1rtm1.1Ceva/Npy1rtm1.1Ceva
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-cre)LC1Bjd/0
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL 		decreased circulating leptin level J:180396
decreased epididymal fat pad weight J:180396
decreased locomotor activity J:180396
decreased subcutaneous adipose tissue amount J:180396
decreased total fat pad weight J:180396
increased anxiety-related response J:180396
increased circulating corticosterone level J:180396
slow postnatal weight gain J:180396
Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6 		abnormal immune cell physiology J:118850
abnormal immune system organ morphology J:118850
abnormal immune system physiology J:118850
abnormal immunoglobulin level J:118850
abnormal inflammatory response J:118850
abnormal lymph node cell ratio J:118850
abnormal macrophage physiology J:118850
abnormal neuron differentiation J:92582
abnormal professional antigen presenting cell physiology J:118850
abnormal spleen morphology J:118850
abnormal splenic cell ratio J:118850
abnormal T cell activation J:118850
abnormal T cell number J:118850
abnormal T-helper 1 physiology J:118850
decreased B cell number J:118850
decreased CD8-positive, alpha-beta T cell number J:118850
decreased circulating interleukin-12 level J:118850
decreased circulating tumor necrosis factor level J:118850
decreased IgG2a level J:118850
decreased interferon-gamma secretion J:118850
decreased marginal zone B cell number J:118850
decreased mature B cell number J:118850
decreased susceptibility to type IV hypersensitivity reaction J:118850
decreased susceptibility to xenobiotic induced morbidity/mortality J:124729
decreased transitional stage B cell number J:118850
hyperactivity J:92440
increased aggression towards mice J:92440
increased CD4-positive, alpha-beta T cell number J:118850
increased CD8-positive, alpha-beta T cell number J:118850
increased IgA level J:118850
increased IgG2b level J:118850
increased IgM level J:118850
increased immunoglobulin level J:118850
increased litter size J:92440
increased single-positive T cell number J:118850
small spleen J:118850
Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: C57BL/6 		abnormal olfactory sensory neuron morphology J:132859
abnormal postnatal subventricular zone morphology J:132859
abnormal rostral migratory stream morphology J:132859
decreased neuronal precursor cell number J:132859
Npy1rtm1Aka/Npy1rtm1Aka
involves: C57BL/6 * CBA 		abnormal eating behavior J:60632
obese J:60632
Npy1rtm1Mnak/Npy1rtm1Mnak
involves: 129P2/OlaHsd * C57BL/6 		normal behavior/neurological phenotype J:51684
decreased energy expenditure J:51684
impaired glucose tolerance J:51684
increased body weight J:51684
increased circulating insulin level J:51684
increased gonadal fat pad weight J:51684
increased retroperitoneal fat pad weight J:51684
Npy1rtm1Pern/Npy1rtm1Pern
Not Specified 		abnormal righting response J:71826
Npy1rtm1Tped/Npy1rtm1Tped
B6.129P2-Npy1rtm1Tped 		abnormal cardiovascular system physiology J:101870
abnormal glucose homeostasis J:102554
abnormal glycogen level J:102554
abnormal sympathetic system morphology J:101870
normal behavior/neurological phenotype J:108001
cardiac interstitial fibrosis J:101870
decreased exploration in new environment J:101870
decreased heart rate J:101870
hyperglycemia J:102554
impaired behavioral response to alcohol J:109207
increased adipocyte glucose uptake J:102554
increased alcohol consumption J:109207
increased circulating corticosterone level J:87424
increased circulating insulin level J:87424, J:102554
increased circulating leptin level J:87424
increased epididymal fat pad weight J:102554
increased percent body fat/body weight J:102554
increased retroperitoneal fat pad weight J:87424
obese J:87424
Npy1rtm1Tped/Npy1rtm1Tped
involves: 129P2/OlaHsd * C57BL/6 		abnormal energy expenditure J:47972
abnormal vasoconstriction J:47972
decreased compensatory feeding amount J:47972
decreased food intake J:47972
decreased locomotor activity J:47972
decreased oxygen consumption J:47972
increased circulating free fatty acids level J:47972
increased circulating insulin level J:47972
increased circulating leptin level J:47972
increased total body fat amount J:47972
normal mortality/aging J:47972
obese J:47972
Npy1rtm1Wpg/Npy1rtm1Wpg
involves: 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:92582
Npy1rtm1Wpg/Npy1rtm1Wpg
Tg(Col1a1-cre)2Bek/0
involves: CD-1 		abnormal bone ossification J:170291
abnormal osteoblast physiology J:170291
increased bone mineral content J:170291
increased bone mineral density J:170291
increased bone strength J:170291
increased bone trabecula number J:170291
increased diameter of femur J:170291
increased trabecular bone thickness J:170291
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11/12/2024
MGI 6.24 		The Jackson Laboratory