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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gclc
glutamate-cysteine ligase, catalytic subunit
MGI:104990
27 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gclctm1c(EUCOMM)Wtsi/Gclc+
Tg(Cryaa-cre)10Mlr/0
involves: 129S4/SvJaeSor * C57BL/6N * FVB/N 		oxidative stress J:194778
Gclctm1c(EUCOMM)Wtsi/Gclctm1c(EUCOMM)Wtsi
Tg(Cryaa-cre)10Mlr/0
involves: 129S4/SvJaeSor * C57BL/6N * FVB/N 		cataract J:194778
nuclear cataract J:194778
oxidative stress J:194778
Gclctm1Dwn/Gclc+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal liver physiology J:66499
Gclctm1Dwn/Gclctm1Dwn
involves: 129P2/OlaHsd * C57BL/6J 		embryonic lethality, complete penetrance J:66499
Gclctm1Mwl/Gclc+
involves: 129S7/SvEvBrd * C57BL/6 		no abnormal phenotype detected J:62177
Gclctm1Mwl/Gclctm1Mwl
involves: 129S7/SvEvBrd * C57BL/6 		abnormal embryo development J:62177
abnormal embryonic-extraembryonic boundary morphology J:62177
absent mesoderm J:62177
decreased cell proliferation J:62177
embryonic growth arrest J:62177
embryonic growth retardation J:62177
embryonic lethality between implantation and somite formation, complete penetrance J:62177
failure to gastrulate J:62177
increased embryonic tissue cell apoptosis J:62177
Gclctm1Tdal/Gclctm1Tdal
Pvalbtm1(cre)Arbr/Pvalb+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 		abnormal cingulate gyrus morphology J:197430
Gclctm1Tdal/Gclctm1Tdal
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S6/SvEvTac * C57BL/6 * DBA 		abnormal endoplasmic reticulum morphology J:202376
abnormal homeostasis J:202376
abnormal liver morphology J:202376
abnormal mitochondrial morphology J:202376
abnormal mitochondrial physiology J:202376
decreased mitochondrial number J:202376
hepatic steatosis J:202376
increased circulating alanine transaminase level J:202376
increased circulating aspartate transaminase level J:202376
postnatal growth retardation J:202376
premature death J:202376
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory