Lepr Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lepr
leptin receptor
MGI:104993

113 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apoe^tm1Unc/Apoe^tm1Unc Lepr^db/Lepr^db involves: 129P2/OlaHsd * C57BLKS/J	abnormal retina morphology	J:103714
	abnormal retina vasculature morphology	J:103714
Aqp9^tm1Nlsn/Aqp9^tm1Nlsn Lepr^db/Lepr^db involves: 129S1/Sv * C57BL/6 * C57BLKS/J	decreased circulating glucose level	J:123742
	increased circulating glycerol level	J:123742
Ccr2^{tm1.1(CCR2)Rodb}/Ccr2^{tm1.1(CCR2)Rodb} Lepr^db/Lepr^db involves: C57BL/6 * C57BLKS/J	abnormal urine protein level	J:203000
Cdkn1b^tm1Kin/Cdkn1b⁺ Lepr^db/Lepr^db involves: C57BL/6J * C57BLKS/J	abnormal pancreatic islet morphology	J:96047
	decreased body temperature	J:96047
	hyperglycemia	J:96047
	hyperlipidemia	J:96047
	increased circulating insulin level	J:96047
	increased pancreatic beta cell number	J:96047
	obese	J:96047
	polyphagia	J:96047
Cdkn1b^tm1Kin/Cdkn1b^tm1Kin Lepr^db/Lepr^db involves: C57BL/6J * C57BLKS/J	abnormal pancreatic islet morphology	J:96047
	decreased body temperature	J:96047
	hyperlipidemia	J:96047
	increased circulating insulin level	J:96047
	increased pancreatic beta cell number	J:96047
	obese	J:96047
	polyphagia	J:96047
Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Lepr^db/Lepr^db Tg(Ins2-cre)23Herr/0 involves: 129P2/OlaHsd * C57BL/6J * C57BLKS/J * CBA/J	abnormal pancreatic islet cell apoptosis	J:156725
	hyperglycemia	J:156725
	increased circulating insulin level	J:156725
	increased pancreatic beta cell mass	J:156725
Cxcl12^tm1.1Sjm/Cxcl12^tm1.1Sjm Lepr^tm2(cre)Rck/Lepr⁺ involves: C57BL/6	abnormal hematopoietic system morphology/development	J:194748
Dbsq1^C57BLKS/J/Dbsq1^C3H/HeJ Lepr^db/Lepr^db involves: C3H/HeJ * C57BLKS	abnormal fat pad morphology	J:116038
Dbsq1^C57BLKS/J/Dbsq1^C57BLKS/J Lepr^db/Lepr^db involves: C3H/HeJ * C57BLKS	abnormal fat pad morphology	J:116038
Dbsq2^C3H/HeJ/Dbsq2^C3H/HeJ Lepr^db/Lepr⁺ involves: C3H/HeJ * C57BLKS	increased body weight	J:116038
Dbsq2^C57BLKS/J/Dbsq2^C3H/HeJ Lepr^db/Lepr⁺ involves: C3H/HeJ * C57BLKS	increased body weight	J:116038
Dbsq3^C3H/HeJ/Dbsq3^C3H/HeJ Lepr^db/Lepr⁺ involves: C3H/HeJ * C57BLKS	increased circulating glucose level	J:116038
Dbsq3^C57BLKS/J/Dbsq3^C3H/HeJ Lepr^db/Lepr⁺ involves: C3H/HeJ * C57BLKS	increased circulating glucose level	J:116038
Dock7^m/Dock7⁺ Lepr^db/Lepr⁺ BKS.Cg-Dock7^m +/+ Lepr^db/J	extended life span	J:6081
Foxo1^tm2.1Dac/Foxo1^tm2.1Dac Lepr^db/Lepr^db B6.Cg-Foxo1^tm2.1Dac Lepr^db	impaired glucose tolerance	J:179687
	increased circulating insulin level	J:179687
Gcgr^tm1Mjch/Gcgr^tm1Mjch Lepr^tm1Jke/Lepr^tm1Jke involves: 129 * 129X1/SvJ * C57BL/6J * SJL	increased liver triglyceride level	J:216393
	obese	J:216393
Gdf15^tm1Sjl/Gdf15^tm1Sjl Lepr^db/Lepr^db involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J	abnormal kidney morphology	J:202996
	albuminuria	J:202996
	glomerulosclerosis	J:202996
	hyperglycemia	J:202996
	increased body weight	J:202996
	increased cholesterol level	J:202996
	increased circulating creatinine level	J:202996
	increased circulating HDL cholesterol level	J:202996
	increased fluid intake	J:202996
	increased food intake	J:202996
	increased heart weight	J:202996
	increased kidney weight	J:202996
	increased liver weight	J:202996
	increased urine glucose level	J:202996
	polyuria	J:202996
Gt(ROSA)26Sor^tm2Sho/Gt(ROSA)26Sor⁺ Lepr^tm1.1Chua/Lepr^tm1.1Chua Nts^tm1(cre)Mgmj/Nts⁺ involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB/N	abnormal nervous system electrophysiology	J:176657
Helz2^tm1Tesa/Helz2^tm1Tesa Lepr^db/Lepr^db involves: C57BL/6 * C57BLKS/J	normal growth/size/body region phenotype	J:218127
Insr^tm1Khn/Insr^tm1Khn Lepr^tm1.1Chua/Lepr^tm1.1Chua Tg(Pomc1-cre)16Lowl/0 involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N	abnormal gonadal fat pad morphology	J:192274
	absent corpus luteum	J:192274
	absent mature ovarian follicles	J:192274
	decreased lean body mass	J:192274
	decreased ovulation rate	J:192274
	hyperglycemia	J:192274
	increased abdominal adipose tissue amount	J:192274
	increased circulating leptin level	J:192274
	increased fat cell size	J:192274
	increased percent body fat/body weight	J:192274
	liver inflammation	J:192274
	ovary inflammation	J:192274
	white adipose tissue inflammation	J:192274
Irs2^tm2Mfw/Irs2^tm2Mfw Irs4^tm1.1Mfw/Y Lepr^tm3(cre)Mgmj/Lepr⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal growth/size/body region phenotype	J:221293
	normal homeostasis/metabolism phenotype	J:221293
Jaml^tm1Fnyi/Jaml⁺ Lepr^db/Lepr^db Tg(NPHS2-cre)295Lbh/0 B6.Cg-Lepr^db Jaml^tm1Fnyi Tg(NPHS2-cre)295Lbh	abnormal podocyte morphology	J:300243
	expanded mesangial matrix	J:300243
	increased urine protein level	J:300243
Jaml^tm1Fnyi/Jaml^tm1Fnyi Lepr^db/Lepr^db Tg(NPHS2-cre)295Lbh/0 B6.Cg-Lepr^db Jaml^tm1Fnyi Tg(NPHS2-cre)295Lbh	abnormal podocyte morphology	J:300243
	expanded mesangial matrix	J:300243
	increased urine protein level	J:300243
	renal glomerulus lipidosis	J:300243
Kitl^tm1.1Sjm/Kitl^tm2.1Sjm Lepr^tm2(cre)Rck/Lepr⁺ involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL	decreased hematopoietic cell number	J:180431
	enlarged spleen	J:180431
	extramedullary hematopoiesis	J:180431
	spleen hyperplasia	J:180431
Kitl^tm1.1Sjm/Kitl^tm2.1Sjm Lepr^tm2(cre)Rck/Lepr⁺ Tg(Tek-cre)12Flv/0 involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL	decreased bone marrow cell number	J:180431
	decreased hematopoietic cell number	J:180431
	spleen hyperplasia	J:180431
Lep^ob/Lep⁺ Tg(Apoe-Lepr)1Kry/0 involves: C57BL/6J	increased bone mass	J:88655
Lep^ob/Lep⁺ Tg(Apoe-Lepr)1Kry/0 involves: C57BL/6J	increased total body fat amount	J:88655
Lepr^db-dmpg/Lepr^db-dmpg involves: B10.D2-H8^b/Sn * C57BL/6	abnormal pancreatic beta cell morphology	J:83762
	hyperglycemia	J:83762
	increased circulating insulin level	J:83762
	obese	J:83762
Lepr^db-Pas/Lepr^db-Pas involves: DW/Pas	decreased muscle weight	J:174584
	enlarged liver	J:174584
	enlarged spleen	J:174584
	female infertility	J:174584
	hyperglycemia	J:174584
	increased brown adipose tissue amount	J:174584
	increased circulating cholesterol level	J:174584
	increased circulating insulin level	J:174584
	increased total body fat amount	J:174584
	male infertility	J:174584
	obese	J:31095, J:174584
	polyphagia	J:174584
	short femur	J:174584
	short tail	J:174584
Lepr^db-rlpy/Lepr^db-rlpy involves: NU/J	abnormal pancreatic beta cell morphology	J:83762
	hyperglycemia	J:83762
	increased circulating insulin level	J:83762
	obese	J:83762
Lepr^db/Lepr⁺ Tg(APPswe,PSEN1dE9)85Dbo/0 involves: C3H * C57BL/6 * C57BLKS/J	abnormal circulating cholesterol level	J:186924
	amyloidosis	J:186924
	normal growth/size/body region phenotype	J:186924
	impaired glucose tolerance	J:186924
	increased circulating glucose level	J:186924
	increased circulating insulin level	J:186924
	increased pancreatic beta cell mass	J:186924
	insulin resistance	J:186924
Lepr^db/Lepr^db Nos3^tm1Unc/Nos3^tm1Unc BKS.Cg-Lepr^db Nos3^tm1Unc	abnormal kidney afferent arteriole morphology	J:135864
	abnormal nephron morphology	J:135864
	abnormal renal glomerulus morphology	J:135864
	albuminuria	J:135864
	decreased renal glomerular filtration rate	J:135864
	expanded mesangial matrix	J:135864
	glomerulosclerosis	J:135864
	hyperglycemia	J:135864
	increased body weight	J:135864
	increased circulating creatinine level	J:135864
	increased renal glomerulus basement membrane thickness	J:135864
	increased systemic arterial systolic blood pressure	J:135864
	mesangiolysis	J:135864
	renal glomerulus fibrosis	J:135864
Lepr^db/Lepr^db Plin1^tm1Chan/Plin1^tm1Chan involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J	decreased susceptibility to age related obesity	J:66267
	increased oxygen consumption	J:66267
Lepr^db/Lepr^db Pten^tm1Hwu/Pten^tm1Hwu Tg(Ins2-cre)25Mgn/0 involves: 129S4/SvJae * C57BL/6 * C57BLKS/J * DBA	abnormal pancreatic islet morphology	J:170206
	normal homeostasis/metabolism phenotype	J:170206
	increased body weight	J:170206
	increased insulin secretion	J:170206
	insulin resistance	J:170206
Lepr^db/Lepr^db Repin1^tm1.2Arte/Repin1^tm1.2Arte involves: BALB/c * C57BL/6 * C57BLKS/J	abnormal adipose tissue physiology	J:238672
	decreased body fat mass	J:238672
	decreased body weight	J:238672
	decreased circulating glucose level	J:238672
	increased insulin sensitivity	J:238672
Lepr^db/Lepr^db Rock1^tm1Leiw/Rock1^tm1Leiw involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N	abnormal mitochondrial physiology	J:182287
	albuminuria	J:182287
	enlarged kidney	J:182287
	expanded mesangial matrix	J:182287
	hyperglycemia	J:182287
	increased body size	J:182287
	increased body weight	J:182287
	increased kidney weight	J:182287
	increased renal glomerulus apoptosis	J:182287
	increased renal glomerulus basement membrane thickness	J:182287
	oxidative stress	J:182287
	normal renal/urinary system phenotype	J:182287
Lepr^db/Lepr^db Serpine1^tm1Mlg/Serpine1^tm1Mlg involves: 129S2/SvPas * C57BL/6 * C57BLKS/J	abnormal enzyme/coenzyme activity	J:127478
	abnormal kidney morphology	J:127478
	abnormal renal glomerulus morphology	J:127478
	albuminuria	J:127478
	decreased body size	J:127478
	hyperglycemia	J:127478
	increased blood urea nitrogen level	J:127478
	obese	J:127478
	premature death	J:127478
Lepr^db/Lepr^db Tg(Fabp4-Fcor)1Jnak/0 involves: C57BL/6 * C57BLKS/J * DBA/2	decreased abdominal adipose tissue amount	J:184684
	decreased body weight	J:184684
	decreased white fat cell size	J:184684
	improved glucose tolerance	J:184684
	increased insulin sensitivity	J:184684
	increased oxygen consumption	J:184684
Lepr^db/Lepr^db Tg(SHBG)4-aGlha/0 involves: C57BL/6 * C57BLKS/J * CBA	abnormal adipose tissue morphology	J:232827
	abnormal blood homeostasis	J:232827
	hepatic steatosis	J:232827
	hyperglycemia	J:232827
	increased circulating cholesterol level	J:232827
	increased circulating free fatty acids level	J:232827
	increased circulating insulin level	J:232827
	increased circulating leptin level	J:232827
	increased circulating testosterone level	J:232827
	increased circulating triglyceride level	J:232827
	increased kidney weight	J:232827
	increased liver triglyceride level	J:232827
	increased liver weight	J:232827
	obese	J:232827
Lepr^{Tg(Mth11)1Aig}/Lepr^{Tg(Mth11)1Aig} involves: Him:OF1	enlarged liver	J:61119
	hyperglycemia	J:61119
	increased circulating insulin level	J:61119
	increased urine glucose level	J:61119
	obese	J:61119
	polydipsia	J:61119
	polyuria	J:61119
Lepr^tm1.2Chua/Lepr^tm1.2Chua Nos1^tm1(cre)Mgmj/Nos1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased circulating thyroxine level	J:183754
	decreased locomotor activity	J:183754
	decreased oxygen consumption	J:183754
	increased body weight	J:183754
	increased circulating corticosterone level	J:183754
	increased circulating glucose level	J:183754
	increased circulating insulin level	J:183754
	increased circulating leptin level	J:183754
	increased food intake	J:183754
	increased total body fat amount	J:183754
	reduced female fertility	J:183754

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