Gclm Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gclm
glutamate-cysteine ligase, modifier subunit
MGI:104995

27 phenotypes from 2 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gclm^tm1Tdal/Gclm^tm1Tdal B6.129-Gclm^tm1Tdal	abnormal cingulate gyrus morphology	J:197430
	abnormal nervous system electrophysiology	J:197430
	oxidative stress	J:197430
Gclm^tm1Tdal/Gclm^tm1Tdal involves: 129 * C57BL/6J	decreased circulating cysteine level	J:80927
	decreased cysteine level	J:80927
	increased cellular sensitivity to hydrogen peroxide	J:80927
Gclm^tm1Tjka/Gclm⁺ B6.129-Gclm^tm1Tjka	increased physiological sensitivity to xenobiotic	J:125009
Gclm^tm1Tjka/Gclm^tm1Tjka B6.129-Gclm^tm1Tjka	abnormal ovarian follicle number	J:226942
	abnormal ovarian folliculogenesis	J:226942
	abnormal ovary physiology	J:226942
	abnormal primary ovarian follicle morphology	J:226942
	abnormal primordial ovarian follicle morphology	J:226942
	abnormal secondary ovarian follicle morphology	J:226942
	absent estrous cycle	J:226942
	decreased glutathione level	J:226942
	decreased primordial ovarian follicle number	J:226942
	decreased tertiary ovarian follicle number	J:226942
	normal homeostasis/metabolism phenotype	J:226942
	increased circulating alanine transaminase level	J:125009
	increased follicle recruitment	J:226942
	increased granulosa cell apoptosis	J:226942
	increased granulosa cell proliferation	J:226942
	increased physiological sensitivity to xenobiotic	J:125009
	increased susceptibility to xenobiotic induced morbidity/mortality	J:125009
	oxidative stress	J:226942
	premature ovarian failure	J:226942
	prolonged estrous cycle	J:226942
	prolonged estrus	J:226942
Gclm^tm1Tjka/Gclm^tm1Tjka involves: 129S1/Sv * 129X1/SvJ	increased susceptibility to neuronal excitotoxicity	J:129045
Gclm^tm1Tjka/Gclm^tm1Tjka involves: 129S1/Sv * 129X1/SvJ	oxidative stress	J:129045
Gclm^tm1Tjka/Gclm^tm1Tjka involves: 129S1/Sv * 129X1/SvJ * C57BL/6	increased susceptibility to neuronal excitotoxicity	J:129361
	oxidative stress	J:129361

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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