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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ahr
aryl-hydrocarbon receptor
MGI:105043
145 phenotypes from 12 alleles in 27 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ahrb-1/Ahrb-1
C57BL/6J 		normal homeostasis/metabolism phenotype J:5387
increased inflammatory response J:5244, J:5387
increased physiological sensitivity to xenobiotic J:26440, J:113285, J:132380
increased susceptibility to xenobiotic induced morbidity/mortality J:26440, J:113285
Ahrb-1/Ahrb-1
C58/J 		increased physiological sensitivity to xenobiotic J:26440
increased susceptibility to xenobiotic induced morbidity/mortality J:26440
Ahrb-1/Ahrb-1
involves: C57BL/6J * DBA/2J 		abnormal immune system physiology J:5387
normal homeostasis/metabolism phenotype J:5387
Ahrb-1/Ahrd
involves: 129S1/SvImJ * C57BL/6J 		increased incidence of tumors by chemical induction J:113356
increased physiological sensitivity to xenobiotic J:113356
increased susceptibility to xenobiotic induced morbidity/mortality J:113356
Ahrb-1/Ahrd
involves: C57BL/6 * DBA/2 		increased susceptibility to xenobiotic induced morbidity/mortality J:113285
Ahrb-2/Ahrb-2
A/He 		increased physiological sensitivity to xenobiotic J:26440
increased susceptibility to xenobiotic induced morbidity/mortality J:26440
Ahrb-2/Ahrb-2
C3H/He 		increased physiological sensitivity to xenobiotic J:26440
increased susceptibility to xenobiotic induced morbidity/mortality J:26440
Ahrb-3/Ahrb-3
M. spretus 		normal homeostasis/metabolism phenotype J:22144, J:34840
Ahrd/Ahrd
AKR 		decreased physiological sensitivity to xenobiotic J:26440
decreased susceptibility to xenobiotic induced morbidity/mortality J:26440
Ahrd/Ahrd
B6.D2-Ahrd 		decreased physiological sensitivity to xenobiotic J:113285
decreased susceptibility to xenobiotic induced morbidity/mortality J:113285
Ahrd/Ahrd
DBA/2 		decreased physiological sensitivity to xenobiotic J:26440
decreased susceptibility to xenobiotic induced morbidity/mortality J:26440
Ahrd/Ahrd
DBA/2J 		decreased physiological sensitivity to xenobiotic J:26440, J:132380
decreased susceptibility to xenobiotic induced morbidity/mortality J:26440
Ahrd/Ahrd
involves: 129S1/SvImJ * C57BL/6J 		increased incidence of tumors by chemical induction J:113356
increased physiological sensitivity to xenobiotic J:113356
increased susceptibility to xenobiotic induced morbidity/mortality J:113356
Ahrtm1.2Arte/Ahrtm1.2Arte
involves: C57BL/6NTac 		abnormal cauda epididymis morphology J:210360
abnormal male germ cell apoptosis J:210360
abnormal seminiferous tubule epithelium morphology J:210360
abnormal sperm head morphology J:210360
abnormal spermiation J:210360
coiled sperm flagellum J:210360
decreased epididymis weight J:210360
decreased fertilization frequency J:210360
decreased testis weight J:210360
multinucleated giant male germ cells J:210360
seminiferous tubule degeneration J:210360
teratozoospermia J:210360
Ahrtm1Bra/Ahrtm1Bra
B6.129-Ahrtm1Bra 		abnormal circulating hormone level J:126176
abnormal eye vasculature morphology J:64483
abnormal hepatocyte morphology J:64483
abnormal kidney vasculature morphology J:64483
abnormal liver sinusoid morphology J:64483
decreased liver weight J:64483
decreased physiological sensitivity to xenobiotic J:126176
decreased prostate gland anterior lobe weight J:126176
decreased prostate gland dorsolateral lobe weight J:126176
decreased seminal vesicle weight J:126176
increased body weight J:126176
patent ductus venosus J:64483
persistent hyaloid artery J:64483
Ahrtm1Bra/Ahrtm1Bra
B6.129-Ahrtm1Bra/J 		abnormal chemokine level J:118646
abnormal cytokine level J:118646
abnormal enzyme/coenzyme activity J:100359
abnormal interleukin level J:118646
abnormal macrophage physiology J:118646
abnormal ovary physiology J:59155
abnormal tumor necrosis factor level J:118646
increased physiological sensitivity to xenobiotic J:118646
increased primordial ovarian follicle number J:59155
increased susceptibility to bacterial infection J:118646
increased susceptibility to injury J:100359
lung inflammation J:100359, J:118646
pulmonary alveolar edema J:100359
pulmonary edema J:100359
Ahrtm1Bra/Ahrtm1Bra
involves: 129S1/Sv * 129X1/SvJ 		abnormal branching of the mammary ductal tree J:51158
abnormal ovarian folliculogenesis J:82983
abnormal ovary physiology J:124374
abnormal ovulation J:82983
decreased corpora lutea number J:83527
decreased germ cell number J:83527
decreased ovary weight J:124374
decreased secondary ovarian follicle number J:82983, J:83527
decreased superovulation rate J:124374
decreased tertiary ovarian follicle number J:82983, J:83527
increased primordial ovarian follicle number J:83527
patent ductus venosus J:94465, J:166864
small ovary J:82983
Ahrtm1Bra/Ahrtm1Bra
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cytokine secretion J:148870
abnormal keratinocyte physiology J:148870
abnormal Langerhans cell morphology J:148870
abnormal Langerhans cell physiology J:148870
decreased body weight J:33827
decreased liver weight J:83597
decreased physiological sensitivity to xenobiotic J:83597
decreased spleen germinal center size J:33827
decreased susceptibility to type IV hypersensitivity reaction J:148870
enlarged spleen J:33827
extramedullary hematopoiesis J:33827
increased primordial ovarian follicle number J:59155
liver hyperplasia J:33827
microvesicular hepatic steatosis J:33827
pale liver J:33827
patent ductus venosus J:83597
postnatal growth retardation J:33827
small liver J:33827
Ahrtm1Gonz/Ahrtm1Gonz
involves: 129S4/SvJae 		decreased physiological sensitivity to xenobiotic J:36360
normal reproductive system phenotype J:76280
Ahrtm1Gonz/Ahrtm1Gonz
involves: 129S4/SvJae * C57BL/6J 		decreased litter size J:113285
decreased physiological sensitivity to xenobiotic J:113285
decreased susceptibility to xenobiotic induced morbidity/mortality J:113285
Ahrtm1Gonz/Ahrtm1Gonz
involves: 129S4/SvJae * C57BL/6N 		abnormal atrial thrombosis J:44690
abnormal auchene hair morphology J:44690
abnormal blood vessel morphology J:44690
abnormal coat/ hair morphology J:44690
abnormal colon morphology J:44690
abnormal coronary artery morphology J:44690
abnormal epidermal layer morphology J:44690
abnormal hair follicle morphology J:44690
abnormal hair shaft morphology J:44690
abnormal heart morphology J:44690
abnormal hepatocyte morphology J:25048, J:44690
abnormal liver morphology J:25048, J:44690
abnormal liver physiology J:25048
abnormal skin condition J:44690
abnormal spleen morphology J:44690
abnormal spleen red pulp morphology J:44690
abnormal stomach pyloric region morphology J:44690
abnormal thrombosis J:44690
abnormal uterus morphology J:44690
acanthosis J:44690
alopecia J:44690
bile duct inflammation J:25048
cardiac fibrosis J:44690
chronic diarrhea J:44690
colitis J:44690
decreased litter size J:44690
decreased liver weight J:25048
decreased physiological sensitivity to xenobiotic J:25048
decreased spleen white pulp amount J:44690
dilated piliary canal J:44690
enlarged heart J:44690
enlarged spleen J:44690
folliculitis J:44690
gastric polyps J:44690
heart inflammation J:44690
hypergranulosis J:44690
increased heart weight J:44690
increased hepatoma incidence J:44690
increased inflammatory response J:25048
increased liver adenoma incidence J:44690
liver fibrosis J:25048, J:44690
postnatal growth retardation J:25048
postnatal lethality, incomplete penetrance J:25048
premature death J:44690
rectal prolapse J:44690
reduced female fertility J:44690
scaly skin J:44690
skin lesions J:44690
small spleen J:25048
spleen hypoplasia J:25048
spontaneous skin ulceration J:44690
thick skin J:44690
vascular smooth muscle hypertrophy J:44690
weight loss J:44690
Ahrtm1Yfk/Ahrtm1Yfk
involves: 129S/SvEv * C57BL/6J 		abnormal horizontal vestibuloocular reflex J:195817
abnormal optokinetic reflex J:195817
abnormal urinary bladder morphology J:179919
abnormal urinary bladder urothelium morphology J:179919
abnormal urinary bladder vasculature morphology J:179919
abnormal xenobiotic pharmacokinetics J:82937
cystolithiasis J:179919
decreased physiological sensitivity to xenobiotic J:46346
disorganized retina layers J:195817
normal homeostasis/metabolism phenotype J:179919
increased urinary bladder carcinoma incidence J:179919
increased urine uric acid level J:179919
normal nervous system phenotype J:195817
postnatal growth retardation J:46346
normal renal/urinary system phenotype J:179919
normal skeleton phenotype J:179919
urinary bladder fibrosis J:179919
urinary bladder inflammation J:179919
Ahrtm2Bra/Ahrtm2Bra
involves: 129/Sv * C57BL/6 		decreased liver weight J:83597
decreased physiological sensitivity to xenobiotic J:83597
increased heart weight J:83597
increased spleen weight J:83597
patent ductus venosus J:83597
Ahrtm3.1Bra/Ahrtm3.1Bra
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
B6.Cg-Ahrtm3.1Bra Speer6-ps1Tg(Alb-cre)21Mgn 		normal cardiovascular system phenotype J:104388
decreased physiological sensitivity to xenobiotic J:104388
Ahrtm3.1Bra/Ahrtm3.1Bra
Tg(Nes-cre)1Kln/0
involves: 129/Sv * C57BL/6 * SJL 		abnormal glial cell morphology J:292713
decreased susceptibility to ischemic brain injury J:292713
increased neuronal precursor cell number J:292713
Ahrtm3.1Bra/Ahrtm3.1Bra
Tg(Six3-cre)69Frty/0
Not Specified 		abnormal rod electrophysiology J:265123
increased retina apoptosis J:265123
photoreceptor outer segment degeneration J:265123
retina degeneration J:265123
retina outer nuclear layer degeneration J:265123
retina photoreceptor degeneration J:265123
short photoreceptor outer segment J:265123
Ahrtm3.1Bra/Ahrtm3.1Bra
Tg(Tek-cre)12Flv/0
B6.Cg-Ahrtm3.1Bra Tg(Tek-cre)12Flv 		patent ductus venosus J:104388
Ahrtm3Bra/Ahrtm3Bra
involves: 129/Sv * C57BL/6J * DBA/2 		decreased physiological sensitivity to xenobiotic J:94465
patent ductus venosus J:94465
Ahrtm4.1Bra/Ahrtm4.1Bra
involves: 129/Sv * C57BL/6 		decreased physiological sensitivity to xenobiotic J:141978
enlarged heart J:141978
enlarged spleen J:141978
microvesicular hepatic steatosis J:141978
patent ductus venosus J:141978
small liver J:141978
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory