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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cdh5
cadherin 5
MGI:105057
71 phenotypes from 12 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cdh5tm1.1Ics/Cdh5tm1.1Ics
B6.129(Cg)-Cdh5tm1.1Ics 		abnormal ovary morphology J:214298
abnormal uterus morphology J:214298
abnormal vascular endothelial cell morphology J:214298
edema J:214298
enlarged endometrial glands J:214298
enlarged ovary J:214298
enlarged uterus J:214298
increased vascular permeability J:214298
ovarian follicular cyst J:214298
ovary cyst J:214298
ovary fibrosis J:214298
uterus fibrosis J:214298
uterus hypertrophy J:214298
Cdh5tm1.1Pec/Cdh5tm1.1Pec
Not Specified 		abnormal angiogenesis J:56509
abnormal cardiac outflow tract development J:56509
abnormal intersomitic vessel morphology J:56509
abnormal placenta vasculature J:56509
abnormal somite development J:56509
abnormal vascular development J:56509
abnormal vascular endothelial cell development J:56509
abnormal vasculogenesis J:56509
abnormal vein development J:56509
abnormal vitelline vasculature morphology J:56509
delayed heart development J:56509
embryonic growth arrest J:56509
embryonic lethality during organogenesis, complete penetrance J:56509
normal hematopoietic system phenotype J:56509
increased apoptosis J:56509
small pharyngeal arch J:56509
Cdh5tm1Dvst/Cdh5tm1Dvst
Tg(Cdh5-cre/ERT2)1Rha/0
Not Specified 		abnormal retina vasculature morphology J:189010
Cdh5tm1Dvst/Cdh5tm1Dvst
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
involves: C57BL/6 * CBA 		abnormal retina development J:328283
decreased angiogenesis J:328283
hemorrhage J:328283
increased angiogenesis J:328283
Cdh5tm1Hub/Cdh5tm1Hub
involves: 129S1/Sv * 129X1/SvJ 		abnormal vasculogenesis J:98466
Cdh5tm1Hub/Cdh5tm1Hub
involves: 129S1/Sv * 129X1/SvJ * BALB/cIco 		abnormal cell death J:54177
abnormal intersomitic vessel morphology J:54177
abnormal umbilical artery morphology J:54177
abnormal umbilical cord blood vessel morphology J:54177
abnormal vasculogenesis J:54177
abnormal visceral yolk sac blood island morphology J:54177
absent vitelline blood vessels J:54177
decreased angiogenesis J:54177
dilated dorsal aorta J:54177
distended pericardium J:54177
embryonic growth retardation J:54177
embryonic lethality during organogenesis, complete penetrance J:54177
incomplete embryo turning J:54177
incomplete somite formation J:54177
irregular heartbeat J:54177
pallor J:54177
Cdh5tm1Pec/Cdh5tm1Pec
Not Specified 		abnormal angiogenesis J:56509
abnormal cardiac outflow tract development J:56509
abnormal intersomitic vessel morphology J:56509
abnormal placenta vasculature J:56509
abnormal somite development J:56509
abnormal vascular development J:56509
abnormal vascular endothelial cell development J:56509
abnormal vasculogenesis J:56509
abnormal vein development J:56509
abnormal vitelline vasculature morphology J:56509
delayed heart development J:56509
embryonic growth arrest J:56509
embryonic lethality during organogenesis, complete penetrance J:56509
normal hematopoietic system phenotype J:56509
increased apoptosis J:56509
small pharyngeal arch J:56509
Cdh5tm2(Cdh5)Dvst/Cdh5tm2(Cdh5)Dvst
involves: 129 * C57BL/6 		no abnormal phenotype detected J:177191
Cdh5tm2Pec/Cdh5tm2Pec
Not Specified 		abnormal angiogenesis J:56509
abnormal cardiac outflow tract development J:56509
abnormal intersomitic vessel morphology J:56509
abnormal placenta vasculature J:56509
abnormal somite development J:56509
abnormal vascular development J:56509
abnormal vascular endothelial cell development J:56509
abnormal vasculogenesis J:56509
abnormal vein development J:56509
abnormal vitelline vasculature morphology J:56509
delayed heart development J:56509
embryonic growth arrest J:56509
embryonic lethality during organogenesis, complete penetrance J:56509
normal hematopoietic system phenotype J:56509
increased apoptosis J:56509
small pharyngeal arch J:56509
Cdh5tm3(Cdh5/Ctnna1)Dvst/Cdh5tm3(Cdh5/Ctnna1)Dvst
B6.Cg-Cdh5tm3(Cdh5/Ctnna1)Dvst 		abnormal common myeloid progenitor cell morphology J:213676
abnormal definitive hematopoiesis J:213676
abnormal hematopoietic stem cell physiology J:213676
abnormal lymphatic vessel endothelium morphology J:213676
abnormal lymphatic vessel morphology J:213676
normal cardiovascular system phenotype J:213676
decreased liver weight J:213676
embryonic lethality during organogenesis, incomplete penetrance J:213676
embryonic lethality, complete penetrance J:177191
increased hematopoietic precursor cell number J:213676
lethality throughout fetal growth and development, complete penetrance J:213676
liver hypoplasia J:213676
lymphedema J:213676
small liver J:213676
Cdh5tm3(Cdh5/Ctnna1)Dvst/Cdh5tm3(Cdh5/Ctnna1)Dvst
involves: 129 * C57BL/6 		abnormal cellular extravasation J:177191
abnormal leukocyte migration J:177191
abnormal lymphatic vessel endothelial cell morphology J:213676
abnormal skin physiology J:177191
abnormal vascular permeability J:177191
normal immune system phenotype J:213676
increased leukocyte cell number J:177191
increased neutrophil cell number J:177191
preweaning lethality, incomplete penetrance J:177191
Cdh5tm5Dvst/Cdh5tm5Dvst
B6.Cg-Cdh5tm5Dvst 		abnormal cellular extravasation J:209801
Cdh5tm6Dvst/Cdh5tm6Dvst
B6.Cg-Cdh5tm6Dvst 		abnormal cellular extravasation J:209801
Cdh5tm7Dvst/Cdh5tm7Dvst
Not Specified 		embryonic lethality during organogenesis, complete penetrance J:213676
Cdh5tm8Dvst/Cdh5tm8Dvst
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/10 * CBA/Ca 		normal liver/biliary system phenotype J:213676
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory