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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Was
Wiskott-Aldrich syndrome
MGI:105059
59 phenotypes from 5 alleles in 10 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Cd79atm1(cre)Reth/Cd79a+
Wastm1.1Ldn/Y
involves: BALB/c * C57BL/6 		abnormal B cell physiology J:182528
abnormal renal corpuscle morphology J:182528
decreased B cell number J:182528
decreased follicular B cell number J:182528
decreased marginal zone B cell number J:182528
decreased mature B cell number J:182528
increased anti-chromatin antibody level J:182528
increased anti-double stranded DNA antibody level J:182528
increased anti-single stranded DNA antibody level J:182528
increased autoantibody level J:182528
increased germinal center B cell number J:182528
increased IgM level J:182528
increased plasma cell number J:182528
Cd79atm1(cre)Reth/Cd79a+
Wastm1.1Ldn/Was+
involves: BALB/c * C57BL/6 		abnormal B cell number J:182528
abnormal B cell proliferation J:182528
Cd79atm1(cre)Reth/Cd79a+
Wastm1.1Ldn/Wastm1.1Ldn
involves: BALB/c * C57BL/6 		abnormal B cell physiology J:182528
abnormal renal corpuscle morphology J:182528
decreased B cell number J:182528
decreased follicular B cell number J:182528
decreased marginal zone B cell number J:182528
decreased mature B cell number J:182528
increased anti-chromatin antibody level J:182528
increased anti-double stranded DNA antibody level J:182528
increased anti-single stranded DNA antibody level J:182528
increased autoantibody level J:182528
increased germinal center B cell number J:182528
increased IgM level J:182528
increased plasma cell number J:182528
Wastm1Itl/Y
Not Specified 		abnormal dendritic cell morphology J:153247
abnormal dendritic cell physiology J:153247
abnormal lymphocyte morphology J:153247
decreased NK cell number J:153247
decreased T cell number J:153247
decreased T cell proliferation J:153247
increased anti-double stranded DNA antibody level J:153247
increased B cell number J:153247
increased follicular B cell number J:153247
increased leukocyte cell number J:153247
increased splenocyte number J:153247
spleen hyperplasia J:153247
thrombocytopenia J:153247
Wastm1Itl/Wastm1Itl
Not Specified 		abnormal dendritic cell morphology J:153247
abnormal dendritic cell physiology J:153247
abnormal lymphocyte morphology J:153247
decreased NK cell number J:153247
decreased T cell number J:153247
decreased T cell proliferation J:153247
increased anti-double stranded DNA antibody level J:153247
increased B cell number J:153247
increased follicular B cell number J:153247
increased leukocyte cell number J:153247
increased splenocyte number J:153247
spleen hyperplasia J:153247
thrombocytopenia J:153247
Wastm1Kas/Wastm1Kas
involves: 129/Sv * C57BL/6 		decreased B cell number J:87875
decreased double-positive T cell number J:87875
decreased lymphocyte cell number J:87875
decreased T cell number J:87875
lymphoid hypoplasia J:87875
thrombocytopenia J:87875
thymus hypoplasia J:87875
Wastm1Sbs/Y
involves: 129S6/SvEvTac 		abnormal dendritic cell morphology J:153247
abnormal dendritic cell physiology J:153247
abnormal lymphocyte morphology J:153247
decreased NK cell number J:153247
decreased T cell number J:153247
decreased T cell proliferation J:153247
increased anti-double stranded DNA antibody level J:153247
increased B cell number J:153247
increased follicular B cell number J:153247
increased leukocyte cell number J:153247
increased monocyte cell number J:153247
increased splenocyte number J:153247
spleen hyperplasia J:153247
thrombocytopenia J:153247
Wastm1Sbs/Y
involves: 129S6/SvEvTac * C57BL/6 		abnormal B cell physiology J:182528
abnormal renal corpuscle morphology J:182528
decreased marginal zone B cell number J:182528
decreased mature B cell number J:182528
increased anti-chromatin antibody level J:182528
increased anti-double stranded DNA antibody level J:182528
increased anti-single stranded DNA antibody level J:182528
increased autoantibody level J:182528
increased germinal center B cell number J:182528
increased IgA level J:182528
increased IgE level J:182528
increased IgM level J:182528
increased plasma cell number J:182528
thrombocytopenia J:182528
Wastm1Sbs/Wastm1Sbs
129S6/SvEvTac-Wastm1Sbs/J 		abnormal glomerular mesangium morphology J:180407
abnormal kidney morphology J:180407
expanded mesangial matrix J:180407
glomerulonephritis J:180407
increased IgA level J:180407
increased IgM level J:180407
increased mesangial cell number J:180407
increased urine protein level J:180407
renal glomerular immunoglobulin deposits J:180407
Wastm1Sbs/Wastm1Sbs
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6) 		abnormal crypts of Lieberkuhn morphology J:48836
colitis J:48836
crypts of Lieberkuhn abscesses J:48836
decreased B cell number J:48836
decreased lymphocyte cell number J:48836
decreased T cell number J:48836
decreased T cell proliferation J:48836
normal immune system phenotype J:48836
increased neutrophil cell number J:48836
normal neoplasm J:48836
thrombocytopenia J:48836
Wastm1Sbs/Wastm1Sbs
involves: 129S6/SvEvTac 		abnormal dendritic cell morphology J:153247
abnormal dendritic cell physiology J:153247
abnormal double-negative T cell morphology J:125309
abnormal double-positive T cell morphology J:125309
abnormal lymphocyte morphology J:153247
abnormal thymocyte activation J:125309
decreased NK cell number J:153247
decreased T cell number J:153247
decreased T cell proliferation J:153247
increased anti-double stranded DNA antibody level J:153247
increased B cell number J:153247
increased follicular B cell number J:153247
increased leukocyte cell number J:153247
increased monocyte cell number J:153247
increased splenocyte number J:153247
spleen hyperplasia J:153247
thrombocytopenia J:153247
Wastm1Sbs/Wastm1Sbs
involves: 129S6/SvEvTac * C57BL/6 		abnormal B cell physiology J:182528
abnormal megakaryocyte morphology J:195436
abnormal renal corpuscle morphology J:182528
decreased marginal zone B cell number J:182528
decreased mature B cell number J:182528
increased anti-chromatin antibody level J:182528
increased anti-double stranded DNA antibody level J:182528
increased anti-single stranded DNA antibody level J:182528
increased autoantibody level J:182528
increased germinal center B cell number J:182528
increased IgA level J:182528
increased IgE level J:182528
increased IgM level J:182528
increased plasma cell number J:182528
thrombocytopenia J:182528
Wastm1Sbs/Wastm1Sbs
involves: 129S/SvEv 		abnormal bone marrow cell morphology/development J:84888
abnormal cell migration J:84888
abnormal cytokine secretion J:86835
abnormal mast cell morphology J:86835
abnormal mast cell physiology J:86835
abnormal osteoclast differentiation J:90542
abnormal osteoclast physiology J:90542
Wastm1Sbs/Wastm1Sbs
involves: BALB/c 		abnormal dendritic cell antigen presentation J:84131
decreased T cell proliferation J:84131
normal immune system phenotype J:84131
Wastm1Sbs/Wastm1Sbs
involves: C57BL/6 * CBA 		abnormal B cell physiology J:95909
Wastm2Itl/Y
Not Specified 		abnormal dendritic cell morphology J:153247
abnormal dendritic cell physiology J:153247
abnormal lymphocyte morphology J:153247
decreased NK cell number J:153247
decreased T cell number J:153247
decreased T cell proliferation J:153247
increased anti-double stranded DNA antibody level J:153247
increased B cell number J:153247
increased follicular B cell number J:153247
increased leukocyte cell number J:153247
increased splenocyte number J:153247
thrombocytopenia J:153247
Wastm2Itl/Wastm2Itl
Not Specified 		abnormal dendritic cell morphology J:153247
abnormal dendritic cell physiology J:153247
abnormal lymphocyte morphology J:153247
decreased NK cell number J:153247
decreased T cell number J:153247
decreased T cell proliferation J:153247
increased anti-double stranded DNA antibody level J:153247
increased B cell number J:153247
increased follicular B cell number J:153247
increased leukocyte cell number J:153247
increased splenocyte number J:153247
thrombocytopenia J:153247
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory