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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Clcn2
chloride channel, voltage-sensitive 2
MGI:105061
60 phenotypes from 6 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Clcn2em1Uis/Clcn2+
C57BL/6N-Clcn2em1Uis 		abnormal adrenal gland physiology J:282228
abnormal kidney morphology J:282228
decreased urine chloride ion level J:282228
decreased urine sodium level J:282228
normal endocrine/exocrine gland phenotype J:282228
increased circulating aldosterone level J:282228
increased heart rate J:282228
increased systemic arterial blood pressure J:282228
normal neoplasm J:282228
normal nervous system phenotype J:282228
Clcn2nmf240/Clcn2nmf240
C57BL/6J-Clcn2nmf240/J 		abnormal cone electrophysiology J:160207
abnormal eye electrophysiology J:160207
abnormal photoreceptor outer segment morphology J:160207
abnormal retina photoreceptor layer morphology J:160207
abnormal retina pigment epithelium morphology J:160207
abnormal rod electrophysiology J:160207
abnormal spermatogenesis J:160207
abnormal spermiogenesis J:82238
axon degeneration J:82238
azoospermia J:160207
brain vacuoles J:160207
increased susceptibility to age-related retinal degeneration J:82238, J:160207
neurodegeneration J:82238
retina photoreceptor degeneration J:160207
thin retina outer nuclear layer J:160207
Clcn2nmf289/Clcn2nmf289
CByJ.Cg-Clcn2nmf289/Pjn 		abnormal ocular fundus morphology J:243745
abnormal retina pigment epithelium morphology J:243745
abnormal rod electrophysiology J:243745
azoospermia J:243745
brain vacuoles J:243745
male infertility J:243745
retina photoreceptor degeneration J:243745
Clcn2tm1Mlv/Clcn2tm1Mlv
involves: C57BL/6 		abnormal male germ cell morphology J:77673
abnormal salivary gland physiology J:77673
abnormal Sertoli cell morphology J:77673
abnormal testis morphology J:77673
azoospermia J:77673
increased Leydig cell number J:77673
retina degeneration J:77673
retina outer nuclear layer degeneration J:77673
retina photoreceptor degeneration J:77673
Clcn2tm1Tjj/Clcn2tm1Tjj
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal brain internal capsule morphology J:122365
abnormal brain morphology J:122365
abnormal brainstem morphology J:122365
abnormal cerebellum morphology J:122365
abnormal corpus callosum morphology J:122365
abnormal eye physiology J:68137
abnormal glial cell physiology J:210308
abnormal male germ cell morphology J:68137
abnormal microglial cell physiology J:122365
abnormal myelin sheath morphology J:122365, J:210308
abnormal nerve conduction J:122365
abnormal oligodendrocyte physiology J:210308
abnormal photoreceptor outer segment morphology J:68137
abnormal retina outer nuclear layer morphology J:68137
abnormal seminiferous tubule morphology J:68137
abnormal Sertoli cell development J:68137
abnormal Sertoli cell morphology J:68137
abnormal spermatocyte morphology J:68137
abnormal spinal cord morphology J:122365
abnormal testis development J:68137
azoospermia J:68137
normal behavior/neurological phenotype J:68137, J:122365
brain vacuoles J:122365, J:210308, J:282228
disorganized photoreceptor inner segment J:68137
disorganized photoreceptor outer segment J:68137
normal endocrine/exocrine gland phenotype J:68137
normal homeostasis/metabolism phenotype J:68137
impaired blood-brain barrier function J:122365
increased circulating renin level J:282228
increased Leydig cell number J:68137
male infertility J:68137
normal nervous system phenotype J:122365
retina degeneration J:68137
seminiferous tubule degeneration J:68137
small testis J:68137
testis degeneration J:282228
Clcn2tm2.1Tjj/Clcn2tm2.1Tjj
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal nervous system phenotype J:210308
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory