Rab7 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rab7
RAB7, member RAS oncogene family
MGI:105068

22 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rab7^em2Rwb/Rab7⁺ C57BL/6J-Rab7^em2Rwb/RwbJ	abnormal lysosome morphology	J:346904
	abnormal lysosome physiology	J:346904
	abnormal mitochondrial physiology	J:346904
	abnormal neuron mitochondrial morphology	J:346904
	abnormal sensory neuron innervation pattern	J:346904
	decreased mechanical nociceptive threshold	J:346904
Rab7^tm1.1Ale/Rab7^tm1.1Ale involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	no abnormal phenotype detected	J:101977
Rab7^tm1.1Ale/Rab7^tm1.1Ale Tg(Cd4-cre)1Cwi/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	abnormal autophagy	J:211733
	abnormal T cell morphology	J:211733
	abnormal T cell physiology	J:211733
	abnormal T cell subpopulation ratio	J:211733
	decreased CD4-positive, alpha-beta T cell number	J:211733
	decreased CD8-positive, alpha-beta T cell number	J:211733
	decreased T cell number	J:211733
	decreased T cell proliferation	J:211733
	increased mitochondrial size	J:211733
	oxidative stress	J:211733
Rab7^tm1.2Ale/Rab7⁺ involves: 129S1/Sv * 129X1/SvJ	lethality, incomplete penetrance	J:211733
Rab7^tm1.2Ale/Rab7^tm1.2Ale involves: 129S1/Sv * 129X1/SvJ	embryonic lethality	J:211733
Rab7^tm1.2Ywd/Rab7^tm1.2Ywd involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL	abnormal primitive streak elongation	J:187732
	abnormal visceral endoderm morphology	J:187732
	failure to gastrulate	J:187732

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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