Rbl2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rbl2
RB transcriptional corepressor like 2
MGI:105085

34 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rbl2^{tm1b(EUCOMM)Hmgu}/Rbl2⁺ C57BL/6N-Rbl2^{tm1b(EUCOMM)Hmgu}/J	abnormal retina morphology	J:211773
	increased circulating cholesterol level	J:211773
	increased circulating HDL cholesterol level	J:211773
	persistence of hyaloid vascular system	J:211773
Rbl2^{tm1b(EUCOMM)Hmgu}/Rbl2^{tm1b(EUCOMM)Hmgu} C57BL/6N-Rbl2^{tm1b(EUCOMM)Hmgu}/J	preweaning lethality, incomplete penetrance	J:211773
Rbl2^tm1Mru/Rbl2^tm1Mru involves: 129S4/SvJae * BALB/cJ	abnormal cell proliferation	J:50516
	abnormal developmental patterning	J:50516
	abnormal floor plate morphology	J:50516
	abnormal heart morphology	J:50516
	abnormal myotome development	J:50516
	abnormal neuron differentiation	J:50516
	absent floor plate	J:50516
	absent hindlimb buds	J:50516
	absent notochord	J:50516
	normal cardiovascular system phenotype	J:50516
	normal cellular phenotype	J:50516
	decreased embryo size	J:50516
	normal embryo phenotype	J:50516
	embryonic growth arrest	J:50516
	embryonic lethality during organogenesis, complete penetrance	J:50516
	enlarged heart	J:50516
	failure of heart looping	J:50516
	failure of initiation of embryo turning	J:50516
	normal growth/size/body region phenotype	J:50516
	incomplete somite formation	J:50516
	increased apoptosis	J:50516
	increased neuron apoptosis	J:50516
	normal limbs/digits/tail phenotype	J:50516
	normal mortality/aging	J:50516
	normal muscle phenotype	J:50516
	normal nervous system phenotype	J:50516
	thin myocardium	J:50516
Rbl2^tm1Mru/Rbl2^tm1Mru involves: 129S4/SvJae * BALB/cJ * C57BL/6J	no abnormal phenotype detected	J:50516
Rbl2^tm1Tyj/Rbl2⁺ involves: 129S2/SvPas * C57BL/6	no abnormal phenotype detected	J:34725
Rbl2^tm1Tyj/Rbl2^tm1Tyj involves: 129S2/SvPas * C57BL/6	normal cellular phenotype	J:34725
	normal integument phenotype	J:82802
	no abnormal phenotype detected	J:34725

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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