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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rbl2
RB transcriptional corepressor like 2
MGI:105085
98 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Krastm4Tyj/Kras+
Rbl2tm2Tyj/Rbl2tm2Tyj
involves: 129S4/SvJae 		abnormal bronchiole morphology J:147590
abnormal tumor morphology J:147590
increased lung adenocarcinoma incidence J:147590
increased lung tumor incidence J:147590
increased tumor growth/size J:147590
premature death J:147590
thick pulmonary interalveolar septum J:147590
Rb1tm2Brn/Rb1tm2Brn
Rbl1tm1Tyj/Rbl1tm1Tyj
Rbl2tm2Tyj/Rbl2tm2Tyj
involves: 129 * 129S2/SvPas * 129S4/SvJae 		hematuria J:217195
increased urinary bladder carcinoma incidence J:217195
Rb1tm2Brn/Rb1tm2Brn
Rbl2tm1Tyj/Rbl2tm1Tyj
Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
involves: 129 * 129S2/SvPas * FVB/N 		abnormal myocardial fiber physiology J:97589
decreased heart left ventricle muscle contractility J:97589
decreased heart rate J:97589
dilated heart left ventricle J:97589
edema J:97589
enlarged heart J:97589
increased myocardial fiber size J:97589
premature death J:97589
respiratory distress J:97589
Rb1tm3Tyj/Rb1tm3Tyj
Rbl1tm1Tyj/Rbl1tm1Tyj
Rbl2tm2.1Tyj/Rbl2tm2.1Tyj
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 		increased hepatocellular carcinoma incidence J:177573
Rb1tm3Tyj/Rb1tm3Tyj
Rbl2tm1Tyj/Rbl2tm1Tyj
Tg(Nes-cre)1Atp/0
involves: 129S2/SvPas * 129S4/SvJae * FVB/N 		abnormal retina apoptosis J:91406
decreased tumor-free survival time J:91406
increased retinoblastoma incidence J:91406
transmission ratio distortion J:91406
Rb1tm3Tyj/Rb1tm3Tyj
Rbl2tm2.1Tyj/Rbl2tm2.1Tyj
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal amacrine cell morphology J:119919
abnormal retina horizontal cell morphology J:119919
abnormal retina morphology J:119919
abnormal retina neuronal layer morphology J:119919
absent retina bipolar cells J:119919
absent retina ganglion cell J:119919
decreased retina cone cell number J:119919
increased retina apoptosis J:119919
increased retinoblastoma incidence J:119919
premature death J:119919
retina hypoplasia J:119919
Rb1tm3Tyj/Rb1tm3Tyj
Rbl2tm2Tyj/Rbl2tm2Tyj
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S4/SvJae 		increased lung small cell carcinoma incidence J:160148
increased lung tumor incidence J:160148
premature death J:160148
Rbl1tm1.1Fad/Rbl1tm1.1Fad
Rbl2tm1Tyj/Rbl2tm1Tyj
involves: 129S2/SvPas * C57BL/6 * FVB/N 		abnormal bone mineralization J:217445
abnormal long bone epiphyseal ossification zone morphology J:217445
abnormal long bone epiphyseal plate proliferative zone J:217445
abnormal middle ear ossicle morphology J:217445
abnormal scapular spine morphology J:217445
normal cellular phenotype J:217445
decreased body size J:217445
decreased length of long bones J:217445
decreased long bone epiphyseal plate size J:217445
interparietal bone hypoplasia J:217445
neonatal lethality, incomplete penetrance J:217445
postnatal lethality, complete penetrance J:217445
short femur J:217445
short fibula J:217445
short radius J:217445
short tibia J:217445
short ulna J:217445
small supraoccipital bone J:217445
Rbl1tm1Tyj/Rbl1+
Rbl2tm1Tyj/Rbl2tm1Tyj
involves: 129S2/SvPas * C57BL/6 		normal limbs/digits/tail phenotype J:34725
postnatal growth retardation J:34725
Rbl1tm1Tyj/Rbl1tm1Tyj
Rbl2tm1Tyj/Rbl2+
involves: 129S2/SvPas * C57BL/6 		abnormal forelimb morphology J:34725
decreased body weight J:34725
delayed fertility J:34725
distended abdomen J:34725
postnatal lethality, incomplete penetrance J:34725
reduced female fertility J:34725
short forelimb J:34725
short limbs J:34725
short snout J:34725
Rbl1tm1Tyj/Rbl1tm1Tyj
Rbl2tm1Tyj/Rbl2tm1Tyj
involves: 129S2/SvPas * C57BL/6 		abnormal awl hair morphology J:82802
abnormal breathing pattern J:34725
abnormal chondrocyte morphology J:34725
abnormal craniofacial bone morphology J:34725
abnormal epidermis stratum granulosum morphology J:82802
abnormal forelimb morphology J:34725
abnormal guard hair morphology J:82802
abnormal hair cycle J:82802
abnormal hair follicle development J:82802
abnormal hair follicle orientation J:82802
abnormal humerus morphology J:34725
abnormal keratinocyte differentiation J:82802
abnormal limb bone morphology J:34725
abnormal long bone epiphyseal plate morphology J:34725
abnormal long bone epiphyseal plate proliferative zone J:34725
abnormal rib development J:34725
abnormal supraoccipital bone morphology J:34725
abnormal tooth development J:82802
abnormal tracheal cartilage morphology J:34725
abnormal zigzag hair morphology J:82802
absent incisors J:82802
apnea J:34725
decreased body size J:34725
decreased fetal size J:34725
decreased hair follicle number J:82802
delayed emergence of vibrissae J:82802
delayed endochondral bone ossification J:34725
distended abdomen J:34725
enlarged sebaceous gland J:82802
epidermal hyperplasia J:82802
increased diameter of humerus J:34725
increased diameter of radius J:34725
increased diameter of ulna J:34725
increased width of hypertrophic chondrocyte zone J:34725
interparietal bone hypoplasia J:34725
neonatal lethality, complete penetrance J:34725
parakeratosis J:82802
perinatal lethality, incomplete penetrance J:34725
short humerus J:34725
short limbs J:34725
short radius J:34725
short snout J:34725
short ulna J:34725
small incisors J:82802
small thoracic cage J:34725
underdeveloped hair follicles J:82802
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory