Pou2af1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pou2af1
POU domain, class 2, associating factor 1
MGI:105086

34 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pou2af1^{tm1b(KOMP)Wtsi}/Pou2af1^{tm1b(KOMP)Wtsi} C57BL/6N-Pou2af1^{tm1b(KOMP)Wtsi}/Ucd	decreased lymphocyte cell number	J:211773
	decreased spleen weight	J:211773
	increased neutrophil cell number	J:211773
Pou2af1^tm1Pjln/Pou2af1^tm1Pjln C57BL/6-Pou2af1^tm1Pjln	absent spleen germinal center	J:37085
	decreased B cell number	J:37085
	decreased IgA level	J:37085
	decreased IgG1 level	J:37085
	decreased IgG2a level	J:37085
	decreased IgG2b level	J:37085
	decreased IgG3 level	J:37085
	spleen hypoplasia	J:37085
Pou2af1^tm1Pjln/Pou2af1^tm1Pjln involves: C57BL/6	abnormal B cell differentiation	J:67362
	abnormal T-helper 1 physiology	J:123039
	abnormal T-helper 2 physiology	J:123039
	decreased B cell number	J:67362, J:123039
	decreased immature B cell number	J:67362
	decreased interferon-gamma secretion	J:123039
	decreased interleukin-2 secretion	J:123039
	decreased mature B cell number	J:67362
	decreased T cell number	J:123039
	increased B cell apoptosis	J:67362
	increased interleukin-4 secretion	J:123039
	increased interleukin-13 secretion	J:123039
	increased susceptibility to parasitic infection	J:123039
Pou2af1^tm1Pmt/Pou2af1^tm1Pmt involves: 129P2/OlaHsd * C57BL/6	decreased immunoglobulin level	J:125114
Pou2af1^tm1Rgr/Pou2af1^tm1Rgr either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)	abnormal B cell differentiation	J:35785, J:114816
	abnormal Peyer's patch germinal center morphology	J:35785
	abnormal pre-B cell morphology	J:114816
	absent lymph node germinal center	J:35785
	absent spleen germinal center	J:35785
	arrested B cell differentiation	J:114816
	decreased B cell number	J:114816
	decreased B cell proliferation	J:35785
	decreased body weight	J:35785
	decreased IgA level	J:35785
	decreased IgE level	J:35785
	decreased IgG1 level	J:35785
	decreased IgG2a level	J:35785
	decreased IgG2b level	J:35785
	decreased IgG3 level	J:35785
	decreased IgG level	J:35785
	decreased immunoglobulin level	J:35785
	increased B cell proliferation	J:114816
	increased IgM level	J:35785

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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