Slc6a5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Slc6a5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
MGI:105090

34 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Slc6a5^m1J/Slc6a5⁺ involves: 129S2/SvPas * NOD	abnormal sleep behavior	J:184306
	normal behavior/neurological phenotype	J:184306
	hyperactivity	J:184306
	increased grooming behavior	J:184306
Slc6a5^m1J/Slc6a5^m1J involves: 129S2/SvPas * NOD	abnormal neuromuscular synapse morphology	J:184306
	abnormal neuron physiology	J:184306
	decreased body weight	J:184306
	muscle hypertonia	J:184306
	muscle spasm	J:184306
	postnatal lethality, complete penetrance	J:184306
Slc6a5^{tm1.1(KOMP)Vlcg}/Slc6a5⁺ C57BL/6N-Slc6a5^{tm1.1(KOMP)Vlcg}/Ucd	abnormal lumbar vertebrae morphology	J:211773
	abnormal sacral vertebrae morphology	J:211773
	increased mean corpuscular hemoglobin concentration	J:211773
Slc6a5^{tm1.1(KOMP)Vlcg}/Slc6a5^{tm1.1(KOMP)Vlcg} C57BL/6N-Slc6a5^{tm1.1(KOMP)Vlcg}/Ucd	preweaning lethality, complete penetrance	J:211773
Slc6a5^tm1Betz/Slc6a5^tm1Betz involves: 129P2/OlaHsd	abnormal CNS synaptic transmission	J:86625
	abnormal inhibitory postsynaptic currents	J:86625
	abnormal miniature inhibitory postsynaptic currents	J:86625
	decreased miniature inhibitory postsynaptic current amplitude	J:86625
	decreased miniature inhibitory postsynaptic current frequency	J:86625
	hyperekplexia	J:86625
	impaired righting response	J:86625
	limb grasping	J:86625
	muscle hypertonia	J:86625
	normal nervous system phenotype	J:86625
	postnatal lethality, complete penetrance	J:86625
	slow postnatal weight gain	J:86625
	tremors	J:86625
Slc6a5^trsl/Slc6a5^trsl C57BL/6J-Slc6a5^trsl/GrsrJ	abnormal gait	J:235637
	abnormal survival	J:235637
	decreased body size	J:235637
	lethality at weaning, incomplete penetrance	J:235637
	lethality, incomplete penetrance	J:235637
	malocclusion	J:235637
	premature death	J:235637
	reduced fertility	J:235637
	tonic seizures	J:235637

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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